Sintering behaviour of calcium phosphate filaments for use as hard tissue scaffolds

Calcium phosphate is a natural biomineral and therefore possesses an excellent biocompatibility due to its chemical similarity to human hard tissue (bone and teeth). Calcium phosphate nanoparticles can be precipitated under controlled conditions and used as carrier in biological systems, e.g. to transfer nucleic acids or drugs. Such nanoparticles can also be suitably functionalized with fluorescing dyes, polymeric agents, pro-drugs or activators. The small monodisperse nanoparticles only mildly influence the intracellular calcium level and therefore are not toxic for cells.

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Biomimetic mineralization of zein/calcium phosphate nanocomposite nanofibrous mats for bone tissue scaffolds

CrystEngComm ◽

10.1039/c4ce01287a ◽

2014 ◽

Vol 16 (40) ◽

pp. 9513-9519 ◽

Cited By ~ 17

Author(s):

Cai-Yun Zhang ◽

Wei Zhang ◽

Li-Bo Mao ◽

Yu Zhao ◽

Shu-Hong Yu

Keyword(s):

Calcium Phosphate ◽

Bone Tissue ◽

Tissue Scaffolds ◽

Biomimetic Mineralization

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Induction of hard tissue into pulpless open-apex teeth using collagen-calcium phosphate gel

Journal of Endodontics ◽

10.1016/s0099-2399(78)80263-5 ◽

1978 ◽

Vol 4 (3) ◽

pp. 76-81 ◽

Cited By ~ 51

Author(s):

Alan Nevins ◽

Frances Finkelstein ◽

Robert Laporta ◽

Bernard G. Borden

Keyword(s):

Calcium Phosphate ◽

Hard Tissue

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Mechanical Properties and In Vitro Bioactivity of β-Tri Calcium Phosphate, Merwinite Nanocomposites

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.493-494.582 ◽

2011 ◽

Vol 493-494 ◽

pp. 582-587 ◽

Cited By ~ 1

Author(s):

Marziyeh Abbasi-Shahni ◽

Saeed Hesaraki ◽

Ali Asghar Behnam-Ghader ◽

Masoud Hafezi-Ardakani

Keyword(s):

Mechanical Properties ◽

Fracture Toughness ◽

Calcium Phosphate ◽

Simulated Body Fluid ◽

Body Fluid ◽

Sem Analysis ◽

In Vitro Bioactivity ◽

Hard Tissue ◽

Calcium Phosphate Layer

In this study, nanocomposites based on of β-tri calcium phosphate (β-TCP) and 2.5-10 wt% merwinite nanoparticles were prepared and sintered at 1100-1300°c.The mechanical properties were investigated by measuring compressive strength and fracture toughness. Structural properties were evaluated by XRD, TEM and SEM analysis, and the in vitro bioactivity was studied by soaking the samples in simulated body fluid (SBF). The mechanical strength of the sintered samples wereincreased, by increasing the amount of merwinite phase up to 5 wt%, whereas it decreased when the samples were sintered at 1100 and 1200°c. Nanostructured calcium phosphate layer was formed on the surfaces of the nanocomposites within 1 day immersion in simulated body fluid. Because of appropriate mechanical properties the composite is suggested to be used as substitute for hard tissue.

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Research and Development of Calcium Phosphate Cement

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.353-358.2267 ◽

2007 ◽

Vol 353-358 ◽

pp. 2267-2270

Author(s):

Chang Sheng Liu

Keyword(s):

Calcium Phosphate ◽

Research And Development ◽

Calcium Phosphate Cement ◽

Ambient Conditions ◽

Hard Tissue ◽

Shape Characteristic ◽

Different Types ◽

Tissue Defects

Hydroxyapatite (HAP)-forming calcium phosphate cement (CPC), due to the high biocompatibility, easy-to-shape characteristic, and the capacity to self-setting under ambient conditions, has been widely used for the repair of hard tissue defects. To satisfy the different clinical need, some modified CPC, including porous CPC, fast-biodegradable CPC, injectable CPC, water-resistant CPC, and rhBMP-2/CPC, have been designed and fabricated in recent years. This paper attempts to give an overview of different types of CPC that have being developed at the present time. Meanwhile, the application perspective of these modified CPC is also explored.

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