Novel blasting extrusion processing improved the physicochemical properties of soluble dietary fiber from soybean residue and in vivo evaluation

2014 ◽  
Vol 120 ◽  
pp. 1-8 ◽  
Author(s):  
Ye Chen ◽  
Ran Ye ◽  
Luo Yin ◽  
Ning Zhang
2016 ◽  
Vol 7 (12) ◽  
pp. 4830-4840 ◽  
Author(s):  
Chun Liu ◽  
Xiao-Lu Lin ◽  
Zhili Wan ◽  
Yuan Zou ◽  
Fen-Fen Cheng ◽  
...  

Soy hull soluble dietary fiber possessed favorablein vitrobinding capacities andin vivohypocholesterolemic activity.


2009 ◽  
Vol 74 (8) ◽  
pp. C628-C636 ◽  
Author(s):  
Min Zhang ◽  
Yi Liang ◽  
Ying Pei ◽  
Weiwei Gao ◽  
Zesheng Zhang

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Muhammad Wasim ◽  
Abdul Mannan ◽  
Muhammad Hassham Hassan Bin Asad ◽  
Muhammad Imran Amirzada ◽  
Muhammad Shafique ◽  
...  

Carbamazepine (CBZ) is an antiepileptic drug having low bioavailability due to its hydrophobic nature. In the current study, efforts are made to investigate the effect of dicarboxylic acid coformer spacer groups (aliphatic chain length) on physicochemical properties, relative humidity (RH) stability, and oral bioavailability of CBZ cocrystals. Slurry crystallization technique was employed for the preparation of CBZ cocrystals with the following coformers: adipic (AA), glutaric (GA), succinic (SA), and malonic acid (MA). Powder X-ray diffractometry and Fourier-transform infrared spectroscopy confirmed cocrystal preparation. Physicochemical properties, RH stability, and oral bioavailability of cocrystals were investigated. Among the prepared cocrystals, CBZ-GA showed maximum solubility as well as improved dissolution profile (CBZ-GA > CBZ-MA > CBZ-AA > pure CBZ > CBZ-SA) in ethanol. Maximum RH stability was shown by CBZ-AA, CBZ-SA, and CBZ-MA. In vivo studies confirmed boosted oral bioavailability of cocrystals compared to pure CBZ. Furthermore, in vivo studies depicted the oral bioavailability order of cocrystals as CBZ-GA > CBZ-MA > Tegral® > CBZ-AA > CBZ-SA > pure CBZ. Thus, pharmaceutical scientists can effectively employ cocrystallization technique for tuning physicochemical properties of hydrophobic drugs to achieve the desired oral bioavailability. Overall, results reflect no consistent effect of spacer group on physicochemical properties, RH stability, and oral bioavailability of cocrystals.


2018 ◽  
Vol 17 (2) ◽  
pp. 195-205
Author(s):  
Wang Cai-Hong ◽  
Ni Zhi-Jing ◽  
Ma Yi-Long ◽  
Thakur Kiran ◽  
Zhang Jian-Guo ◽  
...  

Dietary fibers play an important role in the daily diet. Consuming fiber-rich foods have been associated with good health and prevention of various diseases. In the present study, bamboo shoots soluble dietary fiber (SDF) was extracted using enzymatic hydrolysis and acid-alkali soaking chemical method. The methods were compared and analyzed for water solubility, thermodynamic properties, and emulsifying property, and antioxidant activity with an aim to study the in vivo hypolipidemic effect of SDF extracted by the chemical method. The study indicated that the SDF sample extracted by enzymatic hydrolysis displayed good solubility (86.78 g/100 g), thermodynamic properties (ΔH = 180.4 J/g), rheological properties, better emulsifying (88.57%), and antioxidant properties [DPPH free radical scavenging ability (80.50%), hydroxyl radical scavenging ability (83.39%), and ABTS radical scavenging ability (57.94%)]. For in vivo experiments, SDF sample extracted by enzymatic hydrolysis could lower the body weight gain (7.10%) in hyperlipidemic mice, and decrease the total cholesterol, triglyceride, and low-density lipoprotein-cholesterol levels by 28.33%, 19.54%, and 39.02%, respectively, while, it could increase high-density lipoprotein-cholesterol by 39.50%. Due to its lipid lowering effect in mice, it can be further exploited as a potential source of additive for the development of bamboo-based functional foods.


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