Enhanced Y1-receptor-mediated vasoconstrictive action of neuropeptide Y (NPY) in superior mesenteric arteries in portal hypertension

2006 ◽  
Vol 44 (3) ◽  
pp. 512-519 ◽  
Author(s):  
Reiner Wiest ◽  
Lars Jurzik ◽  
Lukas Moleda ◽  
Matthias Froh ◽  
Bernd Schnabl ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Neuropeptide Y ◽  
Mesenteric Arteries ◽  
Y1 Receptor

Neuropeptide Y restores non-receptor-mediated vasoconstrictive action in superior mesenteric arteries in portal hypertension

2015 ◽  
Vol 35 (12) ◽  
pp. 2556-2563 ◽  
Author(s):  
Johannes Hartl ◽  
Peter Dietrich ◽  
Lukas Moleda ◽  
Martina Müller-Schilling ◽  
Reiner Wiest
Keyword(s):  
Portal Hypertension ◽  
Neuropeptide Y ◽  
Mesenteric Arteries

Regulation of food intake by neuropeptide Y in goldfish

2000 ◽  
Vol 279 (3) ◽  
pp. R1025-R1034 ◽  
Author(s):  
Yuwaraj K. Narnaware ◽  
Pierre P. Peyon ◽  
Xinwei Lin ◽  
Richard E. Peter
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Mrna Levels ◽  
Food Ration ◽  
Y1 Receptor ◽  
Daily Food ◽  
Daily Food Ration ◽  
Brain Ventricle ◽  
Dose Dependent Increase ◽  
Dose Dependent

In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.

Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi α subunit function in CHO cells

2008 ◽  
Vol 579 (1-3) ◽  
pp. 13-25 ◽  
Author(s):  
Steven L. Parker ◽  
Michael S. Parker ◽  
Renu Sah ◽  
Ambikaipakan Balasubramaniam ◽  
Floyd R. Sallee
Keyword(s):  
Neuropeptide Y ◽  
Pertussis Toxin ◽  
Cho Cells ◽  
Α Subunit ◽  
Y1 Receptor ◽  
Subunit Function ◽  
Receptor Dimers

Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists

2009 ◽  
Vol 19 (16) ◽  
pp. 4781-4785 ◽  
Author(s):  
Kaimei Cho ◽  
Makoto Ando ◽  
Kensuke Kobayashi ◽  
Hiroshi Miyazoe ◽  
Toshiaki Tsujino ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Y1 Receptor

scholarly journals Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y1 receptor

Pain ◽  
2016 ◽  
Vol 157 (8) ◽  
pp. 1666-1673 ◽  
Author(s):  
Margarida-Martins Oliveira ◽  
Simon Akerman ◽  
Isaura Tavares ◽  
Peter J. Goadsby
Keyword(s):  
Neuropeptide Y ◽  
Y1 Receptor

Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress

2004 ◽  
Vol 89 (6) ◽  
pp. 1471-1478 ◽  
Author(s):  
Paolo Mele ◽  
Alessandra Oberto ◽  
Mariangela Serra ◽  
Maria Giuseppina Pisu ◽  
Ivan Floris ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Neuropeptide Y ◽  
Paraventricular Nucleus ◽  
Restraint Stress ◽  
Y1 Receptor
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