French recommendations for the prevention of ‘emerging extensively drug-resistant bacteria’ (eXDR) cross-transmission

2015 ◽  
Vol 90 (3) ◽  
pp. 186-195 ◽  
Author(s):  
D. Lepelletier ◽  
P. Berthelot ◽  
J.-C. Lucet ◽  
S. Fournier ◽  
V. Jarlier ◽  
...  
Keyword(s):  
Resistant Bacteria ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Cross Transmission

scholarly journals Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care unit dedicated COVID-19

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Guillaume Miltgen ◽  
Thomas Garrigos ◽  
Pascal Cholley ◽  
Marine Deleume ◽  
Nicolas Allou ◽  
...  
Keyword(s):  
Intensive Care ◽  
Enterobacter Cloacae ◽  
Control Measures ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Infection Control Measures ◽  
Extensively Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Cross Transmission ◽  
Difficult Challenge

AbstractConcomitant prevention of SARS-CoV-2 and extensively drug-resistant bacteria transmission is a difficult challenge in intensive care units dedicated to COVID-19 patients. We report a nosocomial cluster of four patients carrying NDM-1 plasmid-encoded carbapenemase-producing Enterobacter cloacae. Two main factors may have contributed to cross-transmission: misuse of gloves and absence of change of personal protective equipment, in the context of COVID-19-associated shortage. This work highlights the importance of maintaining infection control measures to prevent CPE cross-transmission despite the difficult context and that this type of outbreak can potentially involve several species of Enterobacterales.

Extensively drug-resistant bacteria: Which ethical issues?

2017 ◽  
Vol 47 (5) ◽  
pp. 319-323 ◽  
Author(s):  
P. Vassal ◽  
P. Berthelot ◽  
J.P. Chaussinand ◽  
S. Jay ◽  
J.P. de Filippis ◽  
...  
Keyword(s):  
Ethical Issues ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Drug Resistant Bacteria

scholarly journals Design, Engineering and Discovery of Novel α-Helical and β-Boomerang Antimicrobial Peptides against Drug Resistant Bacteria

2020 ◽  
Vol 21 (16) ◽  
pp. 5773 ◽  
Author(s):  
Surajit Bhattacharjya ◽  
Suzana K. Straus
Keyword(s):  
Antimicrobial Peptides ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Antibiotic Development ◽  
Extensively Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Drying Up ◽  
Further Development ◽  
Lps Binding

In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.

scholarly journals Emerging extensively drug-resistant bacteria (eXDR) in France in 2018

2020 ◽  
Vol 50 (8) ◽  
pp. 715-722
Author(s):  
M. Colomb-Cotinat ◽  
S. Soing-Altrach ◽  
A. Leon ◽  
Y. Savitch ◽  
I. Poujol ◽  
...  
Keyword(s):  
Resistant Bacteria ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Drug Resistant Bacteria
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