Proposed amendments regarding the definitions of multidrug-resistant and extensively drug-resistant bacteria

Background and Objective. Antimicrobial resistance is now a major challenge to clinicians for treating patients. Hence, this short term study was undertaken to detect the incidence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacterial isolates in a tertiary care hospital.Material and Methods. The clinical samples were cultured and bacterial strains were identified in the department of microbiology. The antibiotic susceptibility profile of different bacterial isolates was studied to detect MDR, XDR, and PDR bacteria.Results. The antibiotic susceptibility profile of 1060 bacterial strains was studied. 393 (37.1%) bacterial strains were MDR, 146 (13.8%) strains were XDR, and no PDR was isolated. All (100%) Gram negative bacterial strains were sensitive to colistin whereas all (100%) Gram positive bacterial strains were sensitive to vancomycin.Conclusion. Close monitoring of MDR, XDR, or even PDR must be done by all clinical microbiology laboratories to implement effective measures to reduce the menace of antimicrobial resistance.

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Successful treatment of a chronic oroantral fistula infected with extensively drug resistant bacteria using long‐term oesophageal tube feeding and several non‐conventional treatments in a horse

Australian Veterinary Journal ◽

10.1111/avj.13136 ◽

2021 ◽

Author(s):

JR Fletcher ◽

KY Yuen ◽

AJ Stewart ◽

AC Young ◽

JS Gibson ◽

...

Keyword(s):

Successful Treatment ◽

Tube Feeding ◽

Resistant Bacteria ◽

Drug Resistant ◽

Oroantral Fistula ◽

Extensively Drug Resistant ◽

Drug Resistant Bacteria

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Design, Engineering and Discovery of Novel α-Helical and β-Boomerang Antimicrobial Peptides against Drug Resistant Bacteria

International Journal of Molecular Sciences ◽

10.3390/ijms21165773 ◽

2020 ◽

Vol 21 (16) ◽

pp. 5773 ◽

Cited By ~ 7

Author(s):

Surajit Bhattacharjya ◽

Suzana K. Straus

Keyword(s):

Antimicrobial Peptides ◽

Resistant Bacteria ◽

Drug Resistant ◽

Antibiotic Development ◽

Extensively Drug Resistant ◽

Drug Resistant Bacteria ◽

Drying Up ◽

Further Development ◽

Lps Binding

In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.

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