scholarly journals 127 Sensitive skin protection by strengthening the skin barrier with a LCE6A biomimetic green peptide specific to the cornified envelope

2021 ◽  
Vol 141 (10) ◽  
pp. S170
Author(s):  
J. Leignadier ◽  
C. Tubia ◽  
M. Pancarte ◽  
G. Serre ◽  
N. Jonca ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Skin Protection ◽  
Sensitive Skin ◽  
Cornified Envelope

scholarly journals Soothing effect of virgin coriander seed oil on sensitive skin

OCL ◽  
2020 ◽  
Vol 27 ◽  
pp. 49
Author(s):  
Catherine Kern ◽  
Christian Gombert ◽  
Alicia Roso ◽  
Christine Garcia
Keyword(s):  
Seed Oil ◽  
Inflammatory Responses ◽  
Skin Barrier ◽  
Allyl Isothiocyanate ◽  
Sensitive Skin ◽  
Main Hypothesis ◽  
Neurosensory Dysfunction ◽  
Coriander Seed Oil ◽  
Coriander Seed

Sensitive skin is a common condition that concerns many people in the world. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that normally should not provoke such sensations. The main hypothesis attributed to the occurrence of sensitive skin is the disruption of the epidermal barrier and a greater penetration of substances such as irritants. In keratinocytes, the NF-κB pathway, which plays an important role in orchestrating inflammatory responses, is then activated. Regulation of this activation is a key issue to control inflammation. Due to the wide variety of sensory symptoms, neurosensory dysfunction also represents a mechanism to be considered. Some of the cutaneous nerve endings express TRPA1, a sensor of skin barrier insult, which is involved in a variety of physiological or cellular processes including nociception, itch and neurogenic inflammation. Regulation of such sensor activation is also an issue to consider to control neurosensory dysfunction. Coriander seed oil is a 100% virgin oil of coriander seeds and boasts a unique composition of fatty acids. The soothing effect of coriander seed oil on sensitive skins was investigated by studying its capacity to regulate NF-κB and TRPA1 activation. Coriander seed oil allowed the regulation of NF-κB activation induced by TNF-α in an in vitro model of inflammation in keratinocytes. It also regulated the activation of TRPA1 induced by allyl isothiocyanate in an in vitro model of keratinocytes-neurons co-culture. These results are in favor of a soothing effect of coriander seed oil.

scholarly journals Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 862
Author(s):  
Magdalena Trzeciak ◽  
Berenika Olszewska ◽  
Monika Sakowicz-Burkiewicz ◽  
Małgorzata Sokołowska-Wojdyło ◽  
Jerzy Jankau ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
T Cell ◽  
Expression Profiles ◽  
Skin Barrier ◽  
Control Group ◽  
Mrna Levels ◽  
Barrier Dysfunction ◽  
Cornified Envelope ◽  
Protein Levels ◽  
T Cell Lymphomas

The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of both diseases. The levels of FLG, FLG2, RPTN, HRNR, SPRR1A, SPRR1B, SPRR3 and LELP-1 mRNA were determined by qRT-PCR, while protein levels were examined using the ELISA method in skin samples. We have found that mRNA levels of FLG, FLG2, LOR, CRNN and SPRR3v1 were decreased (p ≤ 0.04), whereas mRNA levels of RPTN, HRNR and SPRR1Av1 were increased in lesional and nonlesional AD skin compared to the healthy control group (p ≤ 0.04). The levels of FLG, FLG2, CRNN, SPRR3v1 mRNA increased (p ≤ 0.02) and RPTN, HRNR and SPRR1Av1 mRNA decreased (p ≤ 0.005) in CTCL skin compared to the lesional AD skin. There was a strong correlation between the stage of CTCL and increased SPRR1Av1 gene expression at both mRNA (R = 0.89; p ≤ 0.05) and protein levels (R = 0.94; p ≤ 0.05). FLG, FLG2, RPTN, HRNR and SPRR1A seem to play a key role in skin barrier dysfunction in CTCL and could be considered a biomarker for differential diagnosis of AD and CTCL. SPRR1Av1 transcript levels seem to be a possible marker of CTCL stage, however, further studies on a larger study group are needed to confirm our findings.

scholarly journals Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy

2017 ◽  
Vol 30 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Renée J.H. Richters ◽  
Denise Falcone ◽  
Natallia E. Uzunbajakava ◽  
Babu Varghese ◽  
Peter J. Caspers ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Raman Microspectroscopy ◽  
Sensitive Skin ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

scholarly journals Sensitive skin is highly frequent in extrinsic atopic dermatitis and correlates with disease severity markers but not necessarily with skin barrier impairment

2018 ◽  
Vol 89 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Tsuyoshi Yatagai ◽  
Takatoshi Shimauchi ◽  
Hayato Yamaguchi ◽  
Jun-ichi Sakabe ◽  
Masahiro Aoshima ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Skin Barrier ◽  
Sensitive Skin

scholarly journals Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies

2020 ◽  
Vol 8 (4) ◽  
pp. 29
Author(s):  
Duncan Wotherspoon ◽  
Clare Rogerson ◽  
Ryan F.L. O’Shaughnessy
Keyword(s):  
External Environment ◽  
Terminal Differentiation ◽  
Skin Barrier ◽  
Mrna Translation ◽  
Model Organisms ◽  
Skin Barrier Function ◽  
Cornified Envelope ◽  
Transcriptional Bursting ◽  
Nuclear Degradation ◽  
Cornified Layer

The outer layer of the skin, the epidermis, is the principal barrier to the external environment: post-mitotic cells terminally differentiate to form a tough outer cornified layer of enucleate and flattened cells that confer the majority of skin barrier function. Nuclear degradation is required for correct cornified envelope formation. This process requires mRNA translation during the process of nuclear destruction. In this review and perspective, we address the biology of transcriptional bursting and the formation of ribonuclear particles in model organisms including mammals, and then examine the evidence that these phenomena occur as part of epidermal terminal differentiation.

Sign in / Sign up

Export Citation Format

Share Document