Surface immobilization of biphasic calcium phosphate nanoparticles on 3D printed poly(caprolactone) scaffolds enhances osteogenesis and bone tissue regeneration

2017 ◽  
Vol 55 ◽  
pp. 101-109 ◽  
Author(s):  
Kyu-Sik Shim ◽  
Sung Eun Kim ◽  
Young-Pil Yun ◽  
Daniel I. Jeon ◽  
Hak-Jun Kim ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Bone Tissue Regeneration ◽  
Surface Immobilization ◽  
Calcium Phosphate Nanoparticles ◽  
3D Printed ◽  
Poly Caprolactone

BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration

2014 ◽  
Vol 103 (4) ◽  
pp. 1520-1532 ◽  
Author(s):  
Zhenming Wang ◽  
Kefeng Wang ◽  
Xiong Lu ◽  
Minqi Li ◽  
Hongrui Liu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Bone Tissue Regeneration

scholarly journals Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 146 ◽  
Author(s):  
Tanya J. Levingstone ◽  
Simona Herbaj ◽  
John Redmond ◽  
Helen O. McCarthy ◽  
Nicholas J. Dunne
Keyword(s):  
Gene Therapy ◽  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Viral Vectors ◽  
Bone Repair ◽  
Transfection Efficiency ◽  
Bone Tissue Regeneration ◽  
Calcium Phosphate Nanoparticles

Bone-related injury and disease constitute a significant global burden both socially and economically. Current treatments have many limitations and thus the development of new approaches for bone-related conditions is imperative. Gene therapy is an emerging approach for effective bone repair and regeneration, with notable interest in the use of RNA interference (RNAi) systems to regulate gene expression in the bone microenvironment. Calcium phosphate nanoparticles represent promising materials for use as non-viral vectors for gene therapy in bone tissue engineering applications due to their many favorable properties, including biocompatibility, osteoinductivity, osteoconductivity, and strong affinity for binding to nucleic acids. However, low transfection rates present a significant barrier to their clinical use. This article reviews the benefits of calcium phosphate nanoparticles for RNAi delivery and highlights the role of surface functionalization in increasing calcium phosphate nanoparticles stability, improving cellular uptake and increasing transfection efficiency. Currently, the underlying mechanistic principles relating to these systems and their interplay during in vivo bone formation is not wholly understood. Furthermore, the optimal microRNA targets for particular bone tissue regeneration applications are still unclear. Therefore, further research is required in order to achieve the optimal calcium phosphate nanoparticles-based systems for RNAi delivery for bone tissue regeneration.

Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration

2021 ◽  
Vol 122 ◽  
pp. 111928
Author(s):  
Eduardo H. Backes ◽  
Emanuel M. Fernandes ◽  
Gabriela S. Diogo ◽  
Catarina F. Marques ◽  
Tiago H. Silva ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphates ◽  
Bone Tissue Regeneration ◽  
Aliphatic Polyester ◽  
Composite Scaffolds ◽  
3D Printed

Redefining architectural effects in 3D printed scaffolds through rational design for optimal bone tissue regeneration

2021 ◽  
Vol 25 ◽  
pp. 101168
Author(s):  
Mohammad Mirkhalaf ◽  
Xiao Wang ◽  
Ali Entezari ◽  
Colin R. Dunstan ◽  
Xinquan Jiang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Rational Design ◽  
Bone Tissue Regeneration ◽  
3D Printed ◽  
Architectural Effects
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