scholarly journals Evolution of SARS-CoV-2 immune responses in nursing home residents following full dose of the Comirnaty® COVID-19 vaccine

2021 ◽  
Author(s):  
Estela Giménez ◽  
Juan Alberola ◽  
Ignacio Torres ◽  
Eliseo Albert ◽  
María Jesús Alcaraz ◽  
...  
Keyword(s):  
Nursing Home ◽  
Immune Responses ◽  
Nursing Home Residents ◽  
Full Dose

scholarly journals B and T cell immune responses elicited by the Comirnaty® COVID-19 vaccine in nursing home residents

2021 ◽  
Author(s):  
Ignacio Torres ◽  
Eliseo Albert ◽  
Estela Giménez ◽  
María Jesús Alcaraz ◽  
Pilar Botija ◽  
...  
Keyword(s):  
Nursing Home ◽  
T Cell ◽  
Immune Responses ◽  
Nursing Home Residents ◽  
T Cell Immune Responses

scholarly journals Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the Comirnaty® COVID-19 vaccine in nursing home residents

2021 ◽  
Author(s):  
Beatriz Sánchez-Sendra ◽  
Eliseo Albert ◽  
Joao Zulaica ◽  
Ignacio Torres ◽  
Estela Giménez ◽  
...  
Keyword(s):  
Nursing Home ◽  
Immune Responses ◽  
Neutralizing Antibodies ◽  
Nursing Home Residents ◽  
Protein S ◽  
Study Group ◽  
Gamma Delta ◽  
Activity Profile ◽  
Humoral Immune ◽  
Humoral Immune Responses

ABSTRACTImmunosenescence may impact the functionality and breadth of vaccine-elicited humoral immune responses. The ability of sera to neutralize the SARS-CoV-2 spike protein (S) from Beta, Gamma, Delta, and Epsilon variants of concern (VOCs) relative to the ancestral Wuhan-Hu-1 strain was compared in Comirnaty® COVID-19-vaccinated elderly nursing home residents (n=30) or younger individuals (n=18) and non-vaccinated individuals who recovered from severe COVID-19 (n=19). In all groups, some participants lacked NtAb against one or more VOCs, mainly the Beta variant (15-20%). Serum NtAb titers were lowest against the Beta variant followed by Gamma, Epsilon, and Delta variants. Fold change reduction in NtAb titers relative to the ancestral strain was greatest for the Beta variant (6.7-18.8) followed by Gamma (3.6-6.2), Epsilon (2.9-5.8), and Delta (3.5-4.3) variants, regardless of the study group considered. In summary, older age, frailty, and concurrence of co-morbidities had no impact on the serum NtAb activity profile against SARS-CoV-2 VOCs.

Descriptive Evaluation of Antibody Responses to SARS-CoV-2 Infection in Plasma and Gingival Crevicular Fluid in a Nursing Home Cohort—Arkansas, June–August 2020

2021 ◽  
pp. 1-24
Author(s):  
Nicole E. Brown ◽  
Amanda K. Lyons ◽  
Amy J. Schuh ◽  
Megan M. Stumpf ◽  
Jennifer L. Harcourt ◽  
...  
Keyword(s):  
Nursing Home ◽  
Immune Responses ◽  
Neutralizing Antibodies ◽  
Gingival Crevicular Fluid ◽  
Natural Infection ◽  
Nursing Home Residents ◽  
Convenience Sample ◽  
Non Invasive ◽  
Viral Culture ◽  
Crevicular Fluid

Abstract Objective: Characterize and compare SARS-CoV-2–specific immune responses in plasma and gingival crevicular fluid (GCF) from nursing home residents during and after natural infection Design: Prospective cohort Setting: Nursing home Participants: SARS-CoV-2–infected nursing home residents Methods: A convenience sample of 14 SARS-CoV-2–infected nursing home residents, enrolled 4–13 days after real-time reverse transcription polymerase chain reaction diagnosis, were followed for 42 days. Post diagnosis, plasma SARS-CoV-2–specific pan-Immunoglobulin (Ig), IgG, IgA, IgM, and neutralizing antibodies were measured at 5 timepoints and GCF SARS-CoV-2–specific IgG and IgA were measured at 4 timepoints. Results: All participants demonstrated immune responses to SARS-CoV-2 infection. Among 12 phlebotomized participants, plasma was positive for pan-Ig and IgG in all 12, neutralizing antibodies in 11, IgM in 10, and IgA in 9. Among 14 participants with GCF specimens, GCF was positive for IgG in 13 and IgA in 12. Immunoglobulin responses in plasma and GCF had similar kinetics; median times to peak antibody response was similar across specimen types (4 weeks for IgG; 3 weeks for IgA). Participants with pan-Ig, IgG, and IgA detected in plasma and GCF IgG remained positive through this evaluation’s end 46–55 days post-diagnosis. All participants were viral culture negative by the first detection of antibodies. Conclusions: Nursing home residents had detectable SARS-CoV-2 antibodies in plasma and GCF after infection. Kinetics of antibodies detected in GCF mirrored those from plasma. Non-invasive GCF may be useful for detecting and monitoring immunologic responses in populations unable or unwilling to be phlebotomized.

Evolution of SARS-CoV-2 immune responses in nursing home residents following full dose of the Comirnaty COVID-19 vaccine

2021 ◽  
Author(s):  
Estela Gimenez ◽  
Juan Alberola ◽  
Ignacio Torres ◽  
Eliseo Albert ◽  
Maria Jesus Alcaraz ◽  
...  
Keyword(s):  
T Cells ◽  
Nursing Home ◽  
T Cell ◽  
Immune Responses ◽  
Nursing Home Residents ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Ifn Γ

Objectives: There is scarce information as to the durability of immune responses elicited by the Comirnaty COVID-19 vaccine in nursing home residents. Here, we assessed SARS-CoV-2-Spike (S)-targeted antibody and functional T cell responses at around 6 months after complete vaccination. Methods: The sample comprised 46 residents (34 females; age, 60-100 years), of whom 10 had COVID-19 prior to vaccination. Baseline (median of 17.5 days after vaccination) and follow-up (median, 195 days) plasma specimens were available for quantitation of SARS-CoV-2-S antibodies and enumeration of SARS-CoV-2-S-reactive IFN-γ CD4+ and CD8+ T cells by flow cytometry. Results: In total, 44/45 participants had detectable SARS-CoV-2-S antibodies at follow-up. Overall, antibody levels were found to decrease (median, 4.8 fold). Antibodies waning was more frequent (P<0.001) in SARS-CoV-2 naive (29/35) than in recovered (1/10) residents. SARS-CoV-2-S IFN-γ CD8+ T cells were detected in 33/46 and 24/46 at baseline and follow-up, respectively. The figures for CD4+ T cell counterparts were 12/46 and 30/46. Detectable SARS-CoV-2 IFN-γ CD8+ and CD4+ T cell responses at follow-up were more common in recovered (8/10 and 7/10, respectively) than in naive residents (9/36 and 25/36, respectively). For those with detectable responses at both time points, SARS-CoV-2-S IFN-γ CD8+ T cell frequencies decreased significantly (P=0.001) over time whereas the opposite (P=0.01) was observed in CD4+ T cells. Conclusion: Almost all residents displayed detectable SARS-CoV-2-S-reactive antibodies and T cell responses, respectively, by around 6 months after complete vaccination with Comirnaty COVID-19 vaccine, albeit generally waning in magnitude over time. Keywords: SARS-CoV-2, Comirnaty COVID-19 vaccine, SARS-CoV-2-S antibodies; SARS-CoV-2-S T cells, Nursing home residents.

scholarly journals Longitudinal serologic and viral testing post-SARS-CoV-2 infection and post-receipt of mRNA COVID-19 vaccine in a nursing home cohort—Georgia, October 2020–April 2021

2022 ◽  
Author(s):  
Farrell A Tobolowsky ◽  
Michelle Waltenburg ◽  
Erin D Moritz ◽  
Melia Haile ◽  
Juliana C DaSilva ◽  
...  
Keyword(s):  
Nursing Home ◽  
Immune Responses ◽  
Post Infection ◽  
Nursing Home Residents ◽  
Antibody Detection ◽  
Rt Pcr ◽  
Post Vaccination ◽  
Viral Culture ◽  
Iga Antibodies ◽  
Prospective Longitudinal

Importance: There are limited data describing SARS-CoV-2-specific immune responses and their durability following infection and vaccination in nursing home residents. Objective: To evaluate the quantitative titers and durability of binding antibodies detected after SARS-CoV-2 infection and subsequent COVID-19 vaccination. Design: A prospective longitudinal evaluation included nine visits over 150 days; visits included questionnaire administration, blood collection for serology, and paired anterior nasal specimen collection for testing by BinaxNOW™ COVID-19 Ag Card (BinaxNOW), reverse transcription polymerase chain reaction (RT-PCR), and viral culture. Setting: A nursing home during and after a SARS-CoV-2 outbreak. Participants: 11 consenting SARS-CoV-2-positive nursing home residents. Main Outcomes and Measures: SARS-CoV-2 testing (BinaxNOW™, RT-PCR, viral culture); quantitative titers of binding SARS-CoV-2 antibodies post-infection and post-vaccination (beginning after the first dose of the primary series). Results: Of 10 participants with post-infection serology results, 9 (90%) had detectable Pan-Ig, IgG, and IgA antibodies and 8 (80%) had detectable IgM antibodies. At first antibody detection post-infection, two-thirds (6/9, 67%) of participants were RT-PCR-positive but none were culture positive. Ten participants received vaccination; all had detectable Pan-Ig, IgG, and IgA antibodies through their final observation ≤90 days post-first dose. Post-vaccination geometric means of IgG titers were 10-200-fold higher than post-infection. Conclusions and Relevance: Nursing home residents in this cohort mounted robust immune responses to SARS-CoV-2 post-infection and post-vaccination. The augmented antibody responses post-vaccination are potential indicators of enhanced protection that vaccination may confer on previously infected nursing home residents.

Erratum: Hearing Levels among Elderly Nursing Home Residents

1980 ◽  
Vol 45 (2) ◽  
Author(s):  
Ronald L. Schow ◽  
Michael A. Nerbonne
Keyword(s):  
Nursing Home ◽  
Nursing Home Residents ◽  
Male And Female

In the February 1980 issue of this journal, the report by Ronald L. Schow and Michael A. Nerbonne ("Hearing Levels Among Elderly Nursing Home Residents") contains an error. On page 128, the labels "Male" and "Female" in Table 2 should be reversed.

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