The role of terminal amino group and histidine at the fourth position in the metal ion binding of oligopeptides revisited: Copper(II) and nickel(II) complexes of glycyl-glycyl-glycyl-histamine and its N-Boc protected derivative

2011 ◽  
Vol 105 (1) ◽  
pp. 92-101 ◽  
Author(s):  
Attila Jancsó ◽  
Katalin Selmeczi ◽  
Patrick Gizzi ◽  
Nóra V. Nagy ◽  
Tamás Gajda ◽  
...  
Keyword(s):  
Metal Ion ◽  
Ion Binding ◽  
Amino Group ◽  
Metal Ion Binding ◽  
Terminal Amino ◽  
Fourth Position

Half-sandwich type rhodium(iii)–aminohydroxamate complexes: the role of the position of the amino group in metal ion binding

2018 ◽  
Vol 42 (10) ◽  
pp. 7659-7670 ◽  
Author(s):  
Péter László Parajdi-Losonczi ◽  
Péter Buglyó ◽  
Hana Skakalova ◽  
Jana Kasparkova ◽  
Norbert Lihi ◽  
...  
Keyword(s):  
Metal Ion ◽  
Ion Binding ◽  
Conditional Stability ◽  
Amino Group ◽  
Relative Order ◽  
Metal Ion Binding ◽  
Sandwich Type ◽  
Ph Dependent ◽  
Half Sandwich

Relative order of the pH-dependent conditional stability of the hydroxamate type (O,O) and (Namino,Nhydroxamato) chelates determines the coordination modes in the various mono- and dinuclear complexes of [(η5-Cp*)RhIII(H2O)3]2+ with α-, β- and γ-aminohydroxamic acids.

scholarly journals Cationic Peptides and their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics

2021 ◽  
Vol 22 (21) ◽  
pp. 12028
Author(s):  
Aleksandra Kotynia ◽  
Benita Wiatrak ◽  
Wojciech Kamysz ◽  
Damian Neubauer ◽  
Paulina Jawień ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metal Ion ◽  
Ion Binding ◽  
Cationic Peptides ◽  
Amino Group ◽  
Metal Ion Binding ◽  
Amide Nitrogen ◽  
Peptide Bonds ◽  
Coordination Behavior ◽  
Terminal Amino

Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with potential biological activity. The coordination behavior of all ligands with Cu(II) and Ni(II) ions has been examined. Various analytical methods such as potentiometric titration, UV-Vis and CD spectroscopies, and mass spectrometry were used. All compounds are convenient chelators for metal ion-binding. Two of the ligands tested have histidine residues. Surprisingly, imidazole nitrogen is not involved in the coordination of the metal ion. The N-terminal amino group, Dab side chains, and amide nitrogen atoms of the peptide bonds coordinated Cu(II) and Ni(II) in all the complexes formed. The cytotoxicity of three pseudopeptides and their complexes was evaluated. Moreover, their other model allowed for assessing the attenuation of LPS-induced cytotoxicity and anti-inflammatory activities were also evaluated, the results of which revealed to be very promising.

scholarly journals The role of metal ion binding in the antioxidant mechanisms of reduced and oxidized glutathione in metal-mediated oxidative DNA damage

Metallomics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Elias O. U. Eteshola ◽  
Devin A. Haupt ◽  
Stephen I. Koos ◽  
Lee A. Siemer ◽  
Daniel L. Morris
Keyword(s):  
Dna Damage ◽  
Metal Ion ◽  
Oxidative Dna Damage ◽  
Ion Binding ◽  
Oxidized Glutathione ◽  
Metal Ion Binding ◽  
Reduced And Oxidized Glutathione ◽  
Antioxidant Mechanisms

GSH and GSSG appear to function as antioxidants against metal-mediated oxidative DNA damage by coordinating Fe(ii) and Cu(ii).

Towards the role of metal ions in the structural variability of proteins: CdII speciation of a metal ion binding loop motif

Metallomics ◽  
2011 ◽  
Vol 3 (12) ◽  
pp. 1331 ◽  
Author(s):  
Attila Jancsó ◽  
Dániel Szunyogh ◽  
Flemming H. Larsen ◽  
Peter W. Thulstrup ◽  
Niels Johan Christensen ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Structural Variability ◽  
Binding Loop

Complex Formation between [(η6-p-cymene)Ru(H2O)3]2+and Hydroxycarboxylates or their Sulfur Analogues - The Role of Thiolate Groups in Metal Ion Binding

2014 ◽  
Vol 2014 (30) ◽  
pp. 5204-5216 ◽  
Author(s):  
Dániel Hüse ◽  
Linda Bíró ◽  
János Patalenszki ◽  
Attila Csaba Bényei ◽  
Péter Buglyó
Keyword(s):  
Complex Formation ◽  
Metal Ion ◽  
Ion Binding ◽  
Metal Ion Binding

Role of the Surface-Exposed Leucine 155 in the Metal Ion Binding Loop of the CuA Domain of CytochromecOxidase fromThermus thermophiluson the Function and Stability of the Protein

Biochemistry ◽  
2012 ◽  
Vol 51 (12) ◽  
pp. 2443-2452 ◽  
Author(s):  
Manas Kumar Ghosh ◽  
Jitumani Rajbongshi ◽  
Debajani Basumatary ◽  
Shyamalava Mazumdar
Keyword(s):  
Metal Ion ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Binding Loop
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