scholarly journals Non-invasive and invasive evaluation of aortic valve area in 100 patients with severe aortic valve stenosis: Comparison of cardiac computed tomography with ECHO (transesophageal/transthoracic) and catheter examination

2014 ◽  
Vol 63 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Thomas Anger ◽  
Verena Bauer ◽  
Claudia Plachtzik ◽  
Tobias Geisler ◽  
Meinrad P. Gawaz ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Cardiac Computed Tomography ◽  
Aortic Valve Area ◽  
Non Invasive ◽  
Invasive Evaluation ◽  
Valve Area

scholarly journals AORTIC VALVE AREA MEASURED BY CARDIAC COMPUTED TOMOGRAPHY IS A STRONG PREDICTOR OF FUTURE AORTIC VALVE REPLACEMENT

2014 ◽  
Vol 63 (12) ◽  
pp. A2019
Author(s):  
Linnea Hornbech Larsen ◽  
Klaus Kofoed ◽  
Helle Gervig Carstensen ◽  
Morten Dalsgaard ◽  
Lars Kober ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Cardiac Computed Tomography ◽  
Strong Predictor ◽  
Aortic Valve Area ◽  
Valve Area

Sex differences in aortic valve calcification in severe aortic valve stenosis: association between computer tomography assessed calcification and valvular calcium concentrations

2020 ◽  
Author(s):  
Louise Linde ◽  
Rasmus Carter-Storch ◽  
Nicolaj Lyhne Christensen ◽  
Kristian Altern Øvrehus ◽  
Axel Cosmus Pyndt Diederichsen ◽  
...  
Keyword(s):  
Sex Differences ◽  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Calcium Concentration ◽  
Severe Aortic Stenosis ◽  
Cardiac Computed Tomography ◽  
Aortic Valve Area ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Valve Area

Abstract Aims The aims of this study were to investigate the correlation and sex differences between total valve calcium, valve calcium concentration, and aortic valve calcification (AVC) in explanted valves from patients with severe aortic valve stenosis undergoing aortic valve replacement (AVR). Methods and results Sixty-nine patients with severe aortic stenosis (AS) scheduled for elective AVR underwent echocardiography and cardiac computed tomography (CT) prior to surgery (AVCin vivo) and CT of the explanted aortic valve (AVCex vivo). Explanted valves were prepared in acid solution, sonicated, and analysed with Arsenazo III dye to estimate total valve calcium and valve calcium concentration. Median AVCex vivo was 2082 (1421–2973) AU; mean valve calcium concentration was 1.43 ± 0.42 µmol Ca2+/mg tissue; median total valve calcium 156 (111–255) mg Ca2+, and valve calcium density 52 (35–81) mg/cm2. AVC displayed a strong correlation with total valve calcium (R2 = 0.98, P < 0.001) and a moderate correlation with valve calcium concentration (R2 = 0.62, P < 0.001). Valvular calcium concentration was associated with sex, aortic valve area, and mean gradient. After adjusting for age and estimated glomerular filtration rate, sex and mean gradient remained associated with valve calcium concentrations. Conclusion AVC score provides a strong estimate for total valve calcium but to a lesser degree calcium concentration in the valve tissue of patients with severe AS. Females presented lower valvular calcium concentrations than males irrespective of AS severity, adding evidence and providing support to the important point that sex differences in valvular calcium concentration in AS does not reflect valvular size.

scholarly journals Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications

2019 ◽  
Vol 13 ◽  
pp. 175394471982642
Author(s):  
Kenan Yalta ◽  
Orkide Palabiyik ◽  
Muhammet Gurdogan ◽  
Yekta Gurlertop
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Cardiac Death ◽  
Surrogate Marker ◽  
Adverse Outcomes ◽  
Aortic Valve Area ◽  
Improve Risk Stratification ◽  
Objective Risk ◽  
Practical Implications ◽  
Valve Area

Over recent decades, the prevalence of aortic valve stenosis (AVS) has been constantly increasing possibly owing to the aging of general population. Severe AVS as determined by an aortic valve area (AVA) of <1 cm2 has been regarded as a serious clinical condition potentially associated with a variety of adverse outcomes, including sudden cardiac death (SCD). However, patients with severe AVS (in the absence of overt high-risk features) are usually evaluated and managed exclusively based on symptomatology or imperfect prognostic tools including exercise testing and biomarkers, with a potential risk of mismanagement, suggesting the need for further objective risk stratifiers in this setting. Within this context, copeptin (C-terminal pro-vasopressin), a novel neurohormone widely considered as the surrogate marker of the arginine–vasopressin (AVP) system, may potentially serve as a reliable prognostic and therapeutic guide (e.g. timing of aortic valvular intervention) in patients with severe AVS largely based on its hemodynamic, fibrogenic as well as autonomic implications in these patients. Accordingly, the present paper aims to discuss clinical and pathophysiological implications of copeptin in the setting of AVS along with a summary of biomarkers and other prognostic tools used in this setting.

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