Design, synthesis and performance of Ba-doped derivatives of SrMo0.9Fe0.1O3-δ perovskite as anode materials in SOFCs

Objective: Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Methods: Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine derivatives 16a-c were synthesized. Their chemical structures were characterized through spectral and elemental analysis, cytotoxic activity on five cancer cell lines, caspase-3 activation, tubulin polymerization inhibition and cell cycle analysis were evaluated. Results: Four compounds 3b, 3d, 8 and 13 showed potent activity than doxorubicin on HCT116 and three compounds 3b, 3d and 8 on HEPG2. These promising derivatives showed increase in the level of caspase-3. The trifloromethylphenyl derivatives of pyrazolopyrimidoquinolines 3b and 3d showed considerable tubulin polymerization inhibitory activity. Both compounds arrested cell cycle at G2/M phase and induced apoptosis. Conclusion: Compounds 3b and 3d can be considered as promising anticancer active agents with 70% of colchicine activity on tubulin polymerization inhibition and represent hopeful leads that deserve further investigation and optimization.

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Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520614666140127113218 ◽

2014 ◽

Vol 14 (7) ◽

pp. 984-993 ◽

Cited By ~ 3

Author(s):

Gabriela Luna-Palencia ◽

Federico Martinez-Ramos ◽

Ismael Vasquez-Moctezuma ◽

Manuel Fragoso-Vazquez ◽

Jessica Mendieta-Wejebe ◽

...

Keyword(s):

Valproic Acid ◽

Amino Acid ◽

Anticancer Agents ◽

Experimental Evaluation ◽

Amino Acid Derivatives ◽

Design Synthesis ◽

Derivatives Of

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Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin

Natural Product Research ◽

10.1080/14786419.2020.1806268 ◽

2020 ◽

pp. 1-7

Author(s):

Yan Jin ◽

Yin-hao Ding ◽

Jing-jing Dong ◽

Yan Wei ◽

Shuang-hong Hao ◽

...

Keyword(s):

Design Synthesis ◽

Derivatives Of

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Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

MedChemComm ◽

10.1039/c8md00396c ◽

2018 ◽

Vol 9 (11) ◽

pp. 1905-1909 ◽

Cited By ~ 7

Author(s):

Faustine d'Orchymont ◽

Jeannine Hess ◽

Gordana Panic ◽

Marta Jakubaszek ◽

Lea Gemperle ◽

...

Keyword(s):

Biological Activity ◽

Antimalarial Drug ◽

Biological Evaluation ◽

Design Synthesis ◽

Drug Candidates ◽

Derivatives Of

The design, synthesis, characterization and biological evaluation of new ferrocenyl and ruthenocenyl derivatives of the antimalarial mefloquine is described.

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Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.11.002 ◽

2011 ◽

Vol 19 (1) ◽

pp. 504-512 ◽

Cited By ~ 9

Author(s):

David J. Lapinsky ◽

Ranganadh Velagaleti ◽

Nageswari Yarravarapu ◽

Yi Liu ◽

Yurong Huang ◽

...

Keyword(s):

Dopamine Transporter ◽

Rational Design ◽

Photoaffinity Labeling ◽

Design Synthesis ◽

Pharmacological Evaluation ◽

Derivatives Of

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A novel retractable landing gear of a light amphibious airplane design, synthesis, analysis, and implementation

Aircraft Engineering and Aerospace Technology ◽

10.1108/aeat-10-2020-0237 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Sinchai Chinvorarat ◽

Pumyos Vallikul

Keyword(s):

Impact Load ◽

Landing Gear ◽

Drop Test ◽

Drop Height ◽

Core Element ◽

Design Synthesis ◽

Content Type ◽

And Performance ◽

Correct Path ◽

The Impact

Purpose The purpose of this paper is to present a novel retractable main landing gear for a light amphibious airplane, while the design, synthesis and analysis are given in details for constructing the main landing gear. Design/methodology/approach The constraint three-position synthesis has given the correct path of all linkages that suitably fit the landing gear into the compartment. The additional lock-link is introduced into the design to ensure the securement of the mechanism while landing. Having the telescopic gas-oil shock strut as a core element to absorb the impact load, it enhances the ability and efficiency to withstand higher impact than others type of light amphibious airplane. Findings By kinematics bifurcation analysis, the optimized value of the unlock spring stiffness at 90 N/m can be found to tremendously reduce the extended-retracted linear actuator force from 500 N to 150 N at the beginning of the retraction sequence. This could limit the size and weight of the landing gear actuator of the light amphibious airplane. Practical implications The drop test of the landing gear to comply with the ASTM f-2245 (Standard Specification for Design and Performance of a Light Sport Airplane) reveals that the novel landing gear can withstand the impact load at the drop height determined by the standard. The maximum impact loading 4.8 G occurs at the drop height of 300 mm, and there is no sign of any detrimental or failure of the landing gear or the structure of the light amphibious airplane. The impact settling time response reaches the 2% of steady-state value in approximately 1.2 s that ensure the safety and stability of the amphibious airplane if it subjects to an accidentally hard landing. Originality/value This paper presents unique applications of a retractable main landing gear of a light amphibious airplane. The proposed landing gear functions properly and complies with the drop test standard, ensuring the safety and reliability of the airplane and exploiting the airworthiness certification process.

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