scholarly journals Pluripotent Stem Cells for Uncovering the Role of Mitochondria in Human Brain Function and Dysfunction

2018 ◽  
Vol 430 (7) ◽  
pp. 891-903 ◽  
Author(s):  
Annika Zink ◽  
Josef Priller ◽  
Alessandro Prigione
Keyword(s):  
Stem Cells ◽  
Human Brain ◽  
Pluripotent Stem Cells ◽  
Brain Function

scholarly journals Brain organoids and insights on human evolution

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 760 ◽  
Author(s):  
Alysson R. Muotri
Keyword(s):  
Stem Cells ◽  
Human Brain ◽  
Human Health ◽  
Human Evolution ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
State Of The Art ◽  
Future Perspectives ◽  
Promising Technique ◽  
Current State

Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions. Although the applications for disease modeling in a dish have become routine, the use of these brain organoids as evolutionary tools is only now getting momentum. Here, we will review the current state of the art on the use of brain organoids from different species and the molecular and cellular insights generated from these studies. Besides, we will discuss how this model might be beneficial for human health and the limitations and future perspectives of this technology.

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