scholarly journals The Cellular Location of Rad23, a Polyubiquitin Chain-Binding Protein, Plays a Key Role in Its Interaction with Substrates of the Proteasome

2020 ◽  
Vol 432 (7) ◽  
pp. 2388-2404
Author(s):  
Evelyn Okeke ◽  
Li Chen ◽  
Kiran Madura
Keyword(s):  
Binding Protein ◽  
Polyubiquitin Chain ◽  
Cellular Location

scholarly journals Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation

2007 ◽  
Vol 178 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Dominique T. Brandt ◽  
Sabrina Marion ◽  
Gareth Griffiths ◽  
Takashi Watanabe ◽  
Kozo Kaibuchi ◽  
...  
Keyword(s):  
Cell Migration ◽  
Actin Filament ◽  
Cell Shape ◽  
Actin Polymerization ◽  
Binding Protein ◽  
Subcellular Location ◽  
Scaffold Protein ◽  
Cellular Location ◽  
Inhibitory Domain ◽  
Migrating Cells

The Diaphanous-related formin Dia1 nucleates actin polymerization, thereby regulating cell shape and motility. Mechanisms that control the cellular location of Dia1 to spatially define actin polymerization are largely unknown. In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location. IQGAP1 interacts with Dia1 through a region within the Diaphanous inhibitory domain after the RhoA-mediated release of Dia1 autoinhibition. Both proteins colocalize at the front of migrating cells but also at the actin-rich phagocytic cup in macrophages. We show that IQGAP1 interaction with Dia1 is required for phagocytosis and phagocytic cup formation. Thus, we identify IQGAP1 as a novel component involved in the regulation of phagocytosis by mediating the localization of the actin filament nucleator Dia1.

Identification of a Novel 29-Linked Polyubiquitin Binding Protein, Ufd3, Using Polyubiquitin Chain Analogues†,‡

Biochemistry ◽  
2004 ◽  
Vol 43 (16) ◽  
pp. 4844-4854 ◽  
Author(s):  
Nathaniel S. Russell ◽  
Keith D. Wilkinson
Keyword(s):  
Binding Protein ◽  
Polyubiquitin Chain

Kupffer cell activation by LPS is mediated via LPS binding protein and CD14

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A27
Author(s):  
M FAN ◽  
S GOYERT ◽  
A AMINLARI ◽  
R KLEIN ◽  
L STEINSTRAESSER ◽  
...  
Keyword(s):  
Kupffer Cell ◽  
Cell Activation ◽  
Binding Protein ◽  
Lps Binding

Annexin VI is a Ca2+-sensitive CHSP-28 binding protein present on secretory granule membranes in acini

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
G GROBLEWSKI ◽  
D THOMAS ◽  
W TAFT ◽  
K KASPAR
Keyword(s):  
Secretory Granule ◽  
Binding Protein ◽  
Annexin Vi

235: The RNA-Binding Protein IMP3: A Novel Molecular Marker Predicts Progression of Superficial (TA and T1) Urothelial Carcinomas of Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 78-79
Author(s):  
Lioudmila Sitnikova ◽  
Gary Mendese ◽  
Qin Lui ◽  
Bruce A. Woda ◽  
Di Lu ◽  
...  
Keyword(s):  
Molecular Marker ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Urothelial Carcinomas
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