scholarly journals Folding steps in the fibrillation of functional amyloid: denaturant sensitivity reveals common features in nucleation and elongation

2021 ◽  
pp. 167337
Author(s):  
Thorbjørn V. Sønderby ◽  
Helena Ø. Rasmussen ◽  
Signe A. Frank ◽  
Jan Skov Pedersen ◽  
Daniel E. Otzen
Keyword(s):  
Functional Amyloid ◽  
Common Features

Functional amyloid: widespread in Nature, diverse in purpose

2014 ◽  
Vol 56 ◽  
pp. 207-219 ◽  
Author(s):  
Chi L.L. Pham ◽  
Ann H. Kwan ◽  
Margaret Sunde
Keyword(s):  
Spider Silk ◽  
Epigenetic Inheritance ◽  
Fibrillar Structure ◽  
Cytoplasmic Polyadenylation ◽  
Functional Amyloid ◽  
Interacting Protein ◽  
Diverse Range ◽  
Element Binding Protein ◽  
Functional Amyloids ◽  
Micro Organisms

Amyloids are insoluble fibrillar protein deposits with an underlying cross-β structure initially discovered in the context of human diseases. However, it is now clear that the same fibrillar structure is used by many organisms, from bacteria to humans, in order to achieve a diverse range of biological functions. These functions include structure and protection (e.g. curli and chorion proteins, and insect and spider silk proteins), aiding interface transitions and cell–cell recognition (e.g. chaplins, rodlins and hydrophobins), protein control and storage (e.g. Microcin E492, modulins and PMEL), and epigenetic inheritance and memory [e.g. Sup35, Ure2p, HET-s and CPEB (cytoplasmic polyadenylation element-binding protein)]. As more examples of functional amyloid come to light, the list of roles associated with functional amyloids has continued to expand. More recently, amyloids have also been implicated in signal transduction [e.g. RIP1/RIP3 (receptor-interacting protein)] and perhaps in host defence [e.g. aDrs (anionic dermaseptin) peptide]. The present chapter discusses in detail functional amyloids that are used in Nature by micro-organisms, non-mammalian animals and mammals, including the biological roles that they play, their molecular composition and how they assemble, as well as the coping strategies that organisms have evolved to avoid the potential toxicity of functional amyloid.

Through the prism of Spain. Socio-economic causes of different outcomes of Russian and Spanish civil wars

2017 ◽  
pp. 142-155
Author(s):  
I. Rozinskiy ◽  
N. Rozinskaya
Keyword(s):  
Civil War ◽  
World War I ◽  
Civil Wars ◽  
Spanish Civil War ◽  
Statistical Data ◽  
Well Being ◽  
Russian Civil War ◽  
World War ◽  
Common Features ◽  
Economic Well Being

The article examines the socio-economic causes of the outcome of the Spanish Civil War (1936-1936), which, as opposed to the Russian Civil War, resulted in the victory of the “Whites”. Choice of Spain as the object of comparison with Russia is justified not only by similarity of civil wars occurred in the two countries in the XX century, but also by a large number of common features in their history. Based on statistical data on the changes in economic well-being of different strata of Spanish population during several decades before the civil war, the authors formulate the hypothesis according to which the increase of real incomes of Spaniards engaged in agriculture is “responsible” for their conservative political sympathies. As a result, contrary to the situation in Russia, where the peasantry did not support the Whites, in Spain the peasants’ position predetermined the outcome of the confrontation resulting in the victory of the Spanish analogue of the Whites. According to the authors, the possibility of stable increase of Spanish peasants’ incomes was caused by the nation’s non-involvement in World War I and also by more limited, compared to Russia and some other countries, spending on creation of heavy (primarily military-related) industry in Spain.

Glaube und Vernunft

2015 ◽  
Vol 18 (1) ◽  
pp. 52-65
Author(s):  
Birgit Sandkaulen
Keyword(s):  
Theoretical Approach ◽  
Human Mind ◽  
German Philosophy ◽  
Faith And Reason ◽  
Common Features ◽  
The Relationship

The question of the relationship between faith and reason marks one of the fundamental issues for classical German philosophy. The paper is guided by a systematic interest in identifying some common features in the approaches taken by Kant and Hegel that are also of interest for the contemporary discussion: 1. The specific modernity of Kant’s and Hegel’s considerations, evident in their rejection of the resources traditionally appealed to by religion and rationalist metaphysics; 2. the anti-naturalist conviction that, in contrast to animals, a metaphysical dimension is inscribed into the human mind; and 3. the thesis that metaphysical questions are existential questions arising from an impulse toward freedom, and hence that a purely theoretical approach is inadequate to address them.

Detergent properties as the basis of the dimexide therapeutic effect in AA-amyloidosis infectious nature (clinical case analysis)

2020 ◽  
Vol 24 (2) ◽  
pp. 60-71
Author(s):  
V. Rameev ◽  
L. Kozlovskaya ◽  
A. Rameeva ◽  
P. Tao
Keyword(s):  
Therapeutic Effect ◽  
Medical Practice ◽  
Clinical Case ◽  
Clinical Observation ◽  
Case Analysis ◽  
Systemic Amyloidosis ◽  
Aa Amyloidosis ◽  
Functional Amyloid ◽  
History Of

The article discusses the current possibilities of postinfectious AA-amyloidosis treatment with dimexide on the example of clinical observation, discribes in detail the problem of functional amyloid and debates the prospects of the principle of amyloid resorption in the treatment of systemic amyloidosis. The history of the use of dimexide in medical practice is given, thenecessary dataon the pharmacology of dimexide are presented.

Prospects for the Implementation of Special Conciliation Procedures in the Russian Criminal Process

2020 ◽  
Vol 9 ◽  
pp. 99-104
Author(s):  
E. V. Markovicheva ◽  
Keyword(s):  
Criminal Justice ◽  
Restorative Justice ◽  
Justice System ◽  
Criminal Procedure ◽  
Legal Analysis ◽  
Criminal Proceedings ◽  
Criminal Process ◽  
Traditional System ◽  
Common Features ◽  
Legal Method

In the 21st century, the concept of restorative justice has become widespread in criminal proceedings. The introduction of special compromise procedures into the criminal process allows for the restoration of the rights of the victim and reduces the level of repression in the criminal justice system. The traditional system of punishment is considered ineffective, not conducive to the purpose of compensating for harm caused by the crime. Restorative justice enables the accused to compensate for the harm caused by the crime and is oriented not towards their social isolation, but towards further positive socialization. The introduction of the ideas of restorative justice into the Russian criminal process requires the introduction of special conciliation procedures. The purpose of the article is to reveal promising directions for introducing special conciliation procedures into the Russian criminal process. The use of the formal legal method provided an analysis of the norms of criminal procedure legislation and the practice of its application. Comparative legal analysis revealed common features in the development of models of restorative justice in modern states. Conclusions. The introduction of conciliation procedures into the Russian criminal process is in line with the concept of its humanization and reduction of the level of criminal repression. The consolidation of the mediator»s procedural status and the mediation procedure in the criminal procedure legislation will make it possible to put into practice the elements of restorative justice.

Specificity of Value Orientations of Native Speakers of French and Russian and Their Representation in Proverbs (Based on Dictionaries)

2020 ◽  
pp. 79-88
Author(s):  
Nataliya Yu. Nelyubova ◽  
Keyword(s):  
National Identity ◽  
Ethnic Groups ◽  
Native Speakers ◽  
Mutual Influence ◽  
Value Orientations ◽  
Quantitative Composition ◽  
Russian Culture ◽  
Common Features ◽  
French Culture ◽  
Subjective Factor

This paper presents a linguo-axiological analysis of French and Russian proverbs based on identifying value orientations and creating their hierarchy by studying the names and quantitative dominance of various thematic groups in authentic paroemiological dictionaries. Identification of value orientations allows us to reveal both common features of ethnic groups, which are of interest in the era of globalization and mutual influence of languages and cultures, and specific ones, contributing to the preservation of national identity. The novelty of this research compared to the author’s previous studies lies in the use of two additional lexicographic sources (one French and one Russian). The examined material of the four dictionaries includes more than 30,000 proverbial units. The analysis revealed the presence of a large number of common topics (which can occupy different positions in the value hierarchy of the ethnic groups under study) not only in dictionaries of the same language, but in all four sources. The names of the categories and their quantitative composition allow us to define French culture as individualist, while Russian culture, as collectivist. When constructing a hierarchy, it is important to turn to a larger number of dictionaries and identify common proverbial units in them to avoid the influence of the subjective factor, which is the case when naming and forming categories, as well as of the researcher’s individual approach to the proportion of category names to their corresponding values. The expanding vocabulary and studies on evaluativity in proverbs aiming to identify value and anti-value components within various topics can be used for further research.

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