Stochastic cell loading to minimize nT subject to maximum acceptable probability of tardiness

2015 ◽  
Vol 35 ◽  
pp. 136-143 ◽  
Author(s):  
Gökhan Eğilmez ◽  
Gürsel A. Süer
2017 ◽  
Vol 1 (10) ◽  
pp. 1700085 ◽  
Author(s):  
Ying Li ◽  
Joon Hee Jang ◽  
Crystal Wang ◽  
Bangshun He ◽  
Kai Zhang ◽  
...  

Author(s):  
Philippe Cambos ◽  
Guy Parmentier

During ship life, operating conditions may change, tanker may be converted into FPSO, and flag requirements may be modified. Generally these modifications have few impacts on existing structures; flag requirements only rarely are to be applied retroactively. Nevertheless in some cases modifications of operating condition may induce considerable consequences, making in the worst cases impossible any reengineering. For example converting a common tanker, built with plain steel of grade A into an Offshore Floating Unit able operating in cold region, may require a grade change corresponding to a grade B. It is obviously meaningless to replace all material just because material certificates. Steels used by shipyards have to fulfill Classification society’s requirements dealing with mechanical strength; generally shipbuilding corresponds to a small part of steelmaker’s production. For this reason steelmakers are reluctant to produce steels with mechanical properties corresponding exactly to the minima required. They generally deliver steels already in stock, with higher mechanical characteristics than required. In this case it can be taken advantage of this common practice. In order to demonstrate that the material fulfill the requirements of grade B it has been decided to adopt a statistic approach. At this stage there are two main issues, the first one is that it is needed to provide evidences that the actual material Charpy V characteristics fulfill the requirements of grade B; the second one is to provide these evidences with a minimum testing. To assess this assumption a random check has been carried out. Different probabilistic model have been tested in order to check common approaches and probabilistic model based on physical considerations. In the paper the main assumptions for estimating the minimum Charpy value main assumption in the probabilistic models are recalled, the behavior of empirical sample is examined, the parameters of probability laws fitting the empirical distribution and definitely as accuracy of probability law parameters determination is not perfect with a finite number of specimens the uncertainty in the determination of parameters is taken into account with confidence limits. According to the selected probabilistic model the minimum value corresponds to an acceptable probability of failure, taking into account the target confidence level, or is independent of any acceptable probability of failure and is defined with the same confidence level. At the end it is concluded that a random check with a data treatment assuming a random distribution of Charpy V test results distributed according to a Weibull probability law of the minimum allows providing evidences that with a sufficient confidence level the steel used for the considered structure fulfill the requirements of the new operating conditions.


2012 ◽  
pp. 1201-1219
Author(s):  
Gürsel A. Süer ◽  
Emre M. Mese

In this chapter, cell loading and family scheduling in a cellular manufacturing environment is studied. What separates this study from others is the presence of individual due dates for every job in a family. The performance measure is to minimize the number of tardy jobs. Family splitting among cells is allowed but job splitting is not. Even though family splitting increases number of setups, it increases the possibility of meeting individual job due dates. Two methods are employed in order to solve this problem, namely Mathematical Modeling and Genetic Algorithms. The results showed that Genetic Algorithm found the optimal solution for all problems tested. Furthermore, GA is efficient compared to the Mathematical Modeling especially for larger problems in terms of execution times. The results of experimentation showed that family splitting was observed in all multi-cell solutions, and therefore, it can be concluded that family splitting is a good strategy.


2019 ◽  
Vol 30 (5) ◽  
pp. 1415-1424 ◽  
Author(s):  
Pamela Tiet ◽  
Jie Li ◽  
Wafa Abidi ◽  
Rachael Mooney ◽  
Linda Flores ◽  
...  

2004 ◽  
Vol 37 (6) ◽  
pp. 939-942 ◽  
Author(s):  
Razi Nalim ◽  
Kerem Pekkan ◽  
Hui Bin Sun ◽  
Hiroki Yokota
Keyword(s):  

Author(s):  
Nichola Charles ◽  
Jane L. Liesveld ◽  
Michael R. King

Rare cell enrichment techniques must selectively capture and successfully retain cells that exist at < 5% in a suspension. We developed a device to capture hematopoietic stem and progenitor cells (HSPCs) from adult bone marrow using immobilized adhesion molecules called selectins in the presence of a flow field. While we continue to optimize the immobilized protein surface and improve the selectivity of the device for HSPCs, it appears to be at the expense of cell recovery. To address this issue, we used experimental and computational methods to identify the hydrodynamic factors that contribute to cell capture, and present new designs for the device that could improve HSPC recovery without affecting the selectivity. We tested KG1a cell recovery using four configurations of tubing — straight cylindrical, helical, flattened and axially pinched, and two cell loading conditions: static and continuous oscillatory. We utilized COMSOL 3.4 finite element modeling software to investigate the path of particles introduced into these geometries, the fluid velocities and local wall shear stresses, and the predicted recovery efficiency based on the number of particles that contact and stick to the walls of the geometries. We found that, experimentally, the highest number of cells were recovered using static cell loading in a straight cylindrical tubing, but we predict that a corrugated or pinched geometry could further increase recovery under desirable flow conditions.


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