Frequency analysis approach to study balance control in individuals with multiple sclerosis

2014 ◽  
Vol 222 ◽  
pp. 91-96 ◽  
Author(s):  
Neeta Kanekar ◽  
Yun-Ju Lee ◽  
Alexander S. Aruin
Keyword(s):  
Multiple Sclerosis ◽  
Frequency Analysis ◽  
Balance Control ◽  
Analysis Approach

Test–Retest Reliability of the Mini-BESTest in People With Mild to Moderate Multiple Sclerosis

2021 ◽  
Author(s):  
A Wallin ◽  
M Kierkegaard ◽  
E Franzén ◽  
S Johansson
Keyword(s):  
Multiple Sclerosis ◽  
Measurement Errors ◽  
Balance Control ◽  
Intraclass Correlation ◽  
Repeated Measurements ◽  
Minimal Detectable Change ◽  
Detectable Change ◽  
Limits Of Agreement ◽  
Retest Reliability ◽  
Test Retest Reliability

Abstract Objective The mini-BESTest is a balance measure for assessment of the underlying physiological systems for balance control in adults. Evaluations of test–retest reliability of the mini-BESTest in larger samples of people with multiple sclerosis (MS) are lacking. The purpose of this study was to investigate test–retest reliability of the mini-BESTest total and section sum scores and individual items in people with mild to moderate overall MS disability. Methods This study used a test–retest design in a movement laboratory setting. Fifty-four people with mild to moderate overall MS disability according to the Expanded Disability Status scale (EDSS) were included, with 28 in the mild subgroup (EDSS 2.0–3.5) and 26 in the moderate subgroup (EDSS 4.0–5.5). Test–retest reliability of the mini-BESTest was evaluated by repeated measurements taken 1 week apart. Reliability and measurement error were analyzed. Results Test–retest reliability for the total scores were considered good to excellent, with intraclass correlation coefficients of .88 for the whole sample, .83 for the mild MS subgroup, and .80 for the moderate MS subgroup. Measurement errors were small, with standard error of measurement and minimal detectable change of 1.3 and 3.5, respectively, in mild MS, and 1.7 and 4.7, respectively, in moderate MS. The limits of agreement were − 3.4 and 4.6. Test–retest reliability for the section scores were fair to good or excellent; weighted kappa values ranged from .62 to .83. All items but 1 showed fair to good or excellent test–retest reliability, and percentage agreement ranged from 61% to 100%. Conclusions The mini-BESTest demonstrated good to excellent test–retest reliability and small measurement errors and is recommended for use in people with mild to moderate MS. Impact Knowledge of limits of agreement and minimal detectable change contribute to interpretability of the mini-BESTest total score. The findings of this study enhance the clinical usefulness of the test for evaluation of balance control and for designing individually customized balance training with high precision and accuracy in people with MS.

Antibodies to Myelin Basic Protein and Measles Virus in Multiple Sclerosis: Precursor Frequency Analysis of the Antibody Producing B Cells

Autoimmunity ◽  
1991 ◽  
Vol 11 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Zhang Jingwu ◽  
Ying Chin ◽  
Paula Henderikx ◽  
Robert Medaer ◽  
C-H. Chou ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
B Cells ◽  
Myelin Basic Protein ◽  
Frequency Analysis ◽  
Measles Virus ◽  
Basic Protein ◽  
Precursor Frequency

Imprint of the 11-year solar cycle in reanalyzed and radiosonde datasets: a spatial frequency analysis approach

2011 ◽  
Vol 110 (1-2) ◽  
pp. 85-99 ◽  
Author(s):  
Petr Pišoft ◽  
Eva Holtanová ◽  
Peter Huszár ◽  
Jiří Mikšovský ◽  
Michal Žák
Keyword(s):  
Solar Cycle ◽  
Spatial Frequency ◽  
Frequency Analysis ◽  
Analysis Approach ◽  
Spatial Frequency Analysis

scholarly journals The Role of Clinical and Instrumented Outcome Measures in Balance Control of Individuals with Multiple Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Neeta Kanekar ◽  
Alexander S. Aruin
Keyword(s):  
Multiple Sclerosis ◽  
Balance Control ◽  
Clinical Test ◽  
Balance Performance ◽  
Performance Deficits ◽  
Clinical Scales ◽  
Balance Confidence ◽  
High Fatigue ◽  
Healthy Control ◽  
Stability Limits

Purpose. The aim of the study was to investigate differences in balance control between individuals with multiple sclerosis (MS) and healthy control subjects using clinical scales and instrumented measures of balance and determine relationships between balance measures, fatigue, and disability levels in individuals with MS with and without a history of falls.Method. Twelve individuals with MS and twelve healthy controls were evaluated using the Berg Balance and Activities-specific Balance Confidence Scales, Modified Clinical Test of Sensory Interaction on Balance, and Limits of Stability Tests as well as Fatigue Severity Scale and Barthel Index.Results. Mildly affected individuals with MS had significant balance performance deficits and poor balance confidence levels (P<0.05). MS group had higher sway velocities and diminished stability limits (P<0.05), significant sensory impairments, high fatigue and disability levels (P<0.05). Sway velocity was a significant predictor of balance performance and the ability to move towards stability limits for the MS group. For the MS-fallers group, those with lower disability levels had faster movement velocities and better balance performance.Conclusion. Implementation of both clinical and instrumented tests of balance is important for the planning and evaluation of treatment outcomes in balance rehabilitation of people with MS.

Sensory impairments in quiet standing in subjects with multiple sclerosis

2009 ◽  
Vol 15 (1) ◽  
pp. 59-67 ◽  
Author(s):  
D Cattaneo ◽  
J Jonsdottir
Keyword(s):  
Multiple Sclerosis ◽  
Sensory Input ◽  
Balance Control ◽  
Motor Impairment ◽  
Quiet Standing ◽  
Convenience Sample ◽  
Sensory Inputs ◽  
Sensory Disorders ◽  
Sensory Impairments ◽  
The Impact

Balance disorders and falls are frequently observed in subjects with multiple sclerosis (MS). Along with motor impairment, sensory disorders and integration deficits of sensory inputs lead to inadequate motor responses. The assessment of these sensory disorders in an every day tasks, such as upright stance, increases our knowledge of postural control in this pathology, thus promoting more effective treatments. The aim of the study was to describe sensory impairments and sensory strategies in different sensory conditions. A stabilometric assessment was carried out in a consecutive convenience sample of 53 subjects. The age of the sample was 52.7 (21.1) years; the onset of pathology was 27.20 (14.5) years before the assessment. Balance was assessed in six sensory conditions. The impact of pathology on balance control was shown by the high percentage of abnormal scores: 75% of subjects with MS showed abnormal scores even in the eyes open condition. The alteration of a single sensory input led to an increase of abnormal scores in up to 82% of subjects. Almost all subjects showed abnormal scores in the vestibular conditions where 22% of them fell. The pattern of the subjects’ performance in the six sensory conditions suggests that balance control may be more correlated to the number of reliable sensory inputs than the nature of the sensory input itself.

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