scholarly journals Serum vitamin A, E and C status in cervical cancer patients undergoing Concurrent Chemo-Radiotherapy, an institutional study

2019 ◽  
Vol 18 ◽  
pp. 100107
Author(s):  
Anju Shrivastava ◽  
Satyajit Pradhan ◽  
Surendra Pratap Mishra ◽  
Anupam Kumar Asthana ◽  
Sunil Choudhary ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Vitamin A ◽  
Cancer Patients ◽  
Serum Vitamin

Effect of an individualized food‐based nutritional intervention on serum vitamin A, E, and carotenoids concentrations in recently diagnosed breast cancer patients

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Jessica Avila Prado ◽  
Diana G. Salcido-Sauceda ◽  
Ana T. Limon Miro ◽  
Bertha I. Pacheco Moreno ◽  
Humberto Astiazaran Garcia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin A ◽  
Cancer Patients ◽  
Serum Vitamin ◽  
Nutritional Intervention ◽  
Breast Cancer Patients

scholarly journals Serum Level of Vitamin A in Breast Cancer Patients and Apparently Healthy Women of Lahore, Pakistan

2021 ◽  
Vol 15 (9) ◽  
pp. 2189-2192
Author(s):  
Mahwish Shahzad ◽  
Bushra Iftikhar ◽  
Mehwish Iftikhar ◽  
Sadia Nazeer ◽  
Rabia Akhtar Cheema
Keyword(s):  
Breast Cancer ◽  
Serum Level ◽  
Vitamin A ◽  
Cancer Patients ◽  
Reference Values ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Healthy Women ◽  
Number Of Patients ◽  
Apparently Healthy

Background: Breast cancer is the second leading cause of death among women worldwide. In Asia, Pakistan has the highest number of patients of breast cancer. Chronic inflammation and hormonal imbalances contribute to the redox disruption thus increasing ROS that changes gene expression resulting in carcinogenesis. Antioxidants like Vitamin A may help reduce tissue-level inflammation through different mechanisms by maintaining redox balance within the tissue. Methods: This cross sectional comparative study was used to measure the serum level of vitamin A in breast cancer patients and in apparently healthy women of same age group to determine the involvement, if any, of this vitamin in breast cancer etiology. Out of 90 women that were recruited, 60 were breast cancer patients and 30 were apparently healthy women. Results: Vitamin A level in serum was measured by Enzyme Linked Immunosorbant Assay (ELISA). Serum vitamin A level was lower than the WHO reference values (30-90μg/dl) in all patients (18.62±4.43μg/dl) and apparently healthy women (19.59±3.40μg/dl). Although no difference was seen between patients and controls (p=0.274), nevertheless, more women (28.3%) were severely deficient in vitamin A than normal (6.7%) women. Increase in age significantly decreased vitamin A in both normal and breast cancer patients. Vitamin A level in serum was generally low, when matched with international reference values in patients than apparently healthy women. Conclusion: It is concluded that deficiency of vitamin A might lead to metabolic disturbances that can contribute to the development of cancers like breast cancer. Keywords: breast cancer, ROS, vitamin A, anti oxidants

scholarly journals Serum Vitamin A, E and Carotenoids After 6 Months of an Individualized Nutritional Intervention in Recently Diagnosed Breast Cancer Patients

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 306-306
Author(s):  
Jessica Avila-Prado ◽  
Veronica Lopez-Teros ◽  
Ana Limon-Miro ◽  
Diana Salcido Sauceda ◽  
Bertha I Pacheco-Moreno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin A ◽  
Cancer Patients ◽  
Intervention Program ◽  
Serum Vitamin ◽  
Nutritional Intervention ◽  
Nutrition Intervention ◽  
Breast Cancer Patients ◽  
Serum Retinol ◽  
Antineoplastic Treatment

Abstract Objectives The aim of this study was to evaluate serum concentrations of retinol, carotenoids and α-tocopherol before and after 6 mo of an individualized nutrition intervention program in recently diagnosed breast cancer patients (BCP). Methods This is a pretest-posttest study in recently diagnosed nonmetastatic BPC undergoing antineoplastic treatment. Baseline and final measurements include anthropometry, body composition (dual x-ray absorptiometry), 24 h dietary recall, and the assessment of serum retinol, carotenoids and α-tocopherol. The individualized nutrition intervention was developed based on the macronutrient meal equivalent method, based on women's total energy expenditure, and following the WCRF/AICR guidelines, adapting 1.5 g/kg/d of protein intake, 5–9 servings of fruits and vegetables and a caloric restriction (500–1000 kcal/d) when applicable (BMI ≥ 25 kg/m2). Results Nineteen women between 33 and 68 years of age completed the intervention. At the time of diagnosis, 74% of the women were overweight or obese, and serum retinol was < 1.05 µmol/L in 42% (n = 8). After the intervention, BCP decreased an average of 2.67 kg of body weight (p < 0.001), and lost ∼2 kg of body fat (p < 0.01). After the intervention, serum retinol increased + 0.83 µmol/L (p < 0.001) and α-tocopherol increased + 1.89 µmol/L (p < 0.02) increased, which was positively correlated with a dietary increase of these micronutrients (p < 0.05). No difference was found for provitamin A carotenoids or xantophils (α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene) (p > 0.05). Conclusions The implementation of an individualized nutritional intervention program before and during antineoplastic treatment increased serum vitamin A and E concentration, improving the nutritional status of BCP. This trial was registered at clinicaltrials.gov as NCT03625635. Funding Sources JAP, ATLM received a fellowship from the National Research Council in Mexico.

Oxidant, vitamin A and angiogenic markers in laryngeal cancer patients

2003 ◽  
Vol 117 (11) ◽  
pp. 871-874 ◽  
Author(s):  
N. Kandpal ◽  
G. K. Shukla ◽  
N. Bhatia ◽  
S. P. Agarwal ◽  
S. Saha ◽  
...  
Keyword(s):  
Vitamin A ◽  
Cancer Patients ◽  
Correlation Coefficient ◽  
Laryngeal Cancer ◽  
Laryngeal Carcinoma ◽  
Tnm Classification ◽  
Oxidant Stress ◽  
Serum Vitamin ◽  
Marker Enzyme ◽  
Nodal Involvement

In this study the status of oxidant stress, vitamin A and angiotensin-converting enzyme (ACE) levels were evaluated in cases of laryngeal carcinoma patients from Northern India. In control subjects the levels of malondialdehyde (MDA), vitamin A and ACE were 0.23 ± 0.07 nmole/ml, 2515 ± 84 IU, and 1.4 ± 0.8 U/ml respectively. Thirty laryngeal cancer patients were divided into three groups according to the TNM classification (American Joint Committee on Cancers). In laryngeal cancer patients according to tumour size, MDA and ACE levels increased to 0.32 ± 0.04 nmole/ml and 4.7 ± 0.5 U/ml respectively and the effect was statistically significant (p<0.01). The correlation coefficient between different subgroups was also highly significant (r =0.96, p<0.01). However, serum vitamin A levels decreased to 621 ± 20 IU and the effect was statistically significant (p<0.01). In another two groups of laryngeal cancer patients, a similar pattern of various markers was obtained. Thirty patients with laryngeal carcinoma were divided into four different groups according to nodal involvement and it was observed that in laryngeal cancer patients with no nodal involvement, ACE levels were low 3.6 ± 1.4 U/ml while patients with maximum nodal involvement had the highest levels of ACE 7.1 ± 0.18 U/ml. The correlation coefficient between different groups is highly statistically significant (r = 0.95, p<0.01). In patients with laryngeal cancer the serum MDA and vitamin A levels correlation coefficient between different groups was not significant. It is thus concluded that serum ACE might be a specific test marker for laryngeal cancer disease burden. The use of this marker enzyme for therapeutics is being planned.

scholarly journals Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Travis T. Sims ◽  
Molly B. El Alam ◽  
Tatiana V. Karpinets ◽  
Stephanie Dorta-Estremera ◽  
Venkatesh L. Hegde ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Compositional Variation ◽  
Short Term ◽  
Microbiome Diversity ◽  
Term Survivor

AbstractDiversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in patients receiving radiation therapy. Additionally, current studies investigating the gut microbiome and outcomes in cancer patients may not have adjusted for established risk factors. Here, we sought to determine if diversity and composition of the gut microbiome was independently associated with survival in cervical cancer patients receiving chemoradiation. Our study demonstrates that the diversity of gut microbiota is associated with a favorable response to chemoradiation. Additionally, compositional variation among patients correlated with short term and long-term survival. Short term survivor fecal samples were significantly enriched in Porphyromonas, Porphyromonadaceae, and Dialister, whereas long term survivor samples were significantly enriched in Escherichia Shigella, Enterobacteriaceae, and Enterobacteriales. Moreover, analysis of immune cells from cervical tumor brush samples by flow cytometry revealed that patients with a high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ over the course of radiation therapy. Modulation of the gut microbiota before chemoradiation might provide an alternative way to enhance treatment efficacy and improve treatment outcomes in cervical cancer patients.

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