Oxidant, vitamin A and angiogenic markers in laryngeal cancer patients

In this study the status of oxidant stress, vitamin A and angiotensin-converting enzyme (ACE) levels were evaluated in cases of laryngeal carcinoma patients from Northern India. In control subjects the levels of malondialdehyde (MDA), vitamin A and ACE were 0.23 ± 0.07 nmole/ml, 2515 ± 84 IU, and 1.4 ± 0.8 U/ml respectively. Thirty laryngeal cancer patients were divided into three groups according to the TNM classification (American Joint Committee on Cancers). In laryngeal cancer patients according to tumour size, MDA and ACE levels increased to 0.32 ± 0.04 nmole/ml and 4.7 ± 0.5 U/ml respectively and the effect was statistically significant (p<0.01). The correlation coefficient between different subgroups was also highly significant (r =0.96, p<0.01). However, serum vitamin A levels decreased to 621 ± 20 IU and the effect was statistically significant (p<0.01). In another two groups of laryngeal cancer patients, a similar pattern of various markers was obtained. Thirty patients with laryngeal carcinoma were divided into four different groups according to nodal involvement and it was observed that in laryngeal cancer patients with no nodal involvement, ACE levels were low 3.6 ± 1.4 U/ml while patients with maximum nodal involvement had the highest levels of ACE 7.1 ± 0.18 U/ml. The correlation coefficient between different groups is highly statistically significant (r = 0.95, p<0.01). In patients with laryngeal cancer the serum MDA and vitamin A levels correlation coefficient between different groups was not significant. It is thus concluded that serum ACE might be a specific test marker for laryngeal cancer disease burden. The use of this marker enzyme for therapeutics is being planned.

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Laryngeal Cancer Neck Node Metastases: Patterns of Spread

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v32i1.181 ◽

2017 ◽

Vol 32 (1) ◽

pp. 30-32

Author(s):

Mark Jansen D.G. Austria ◽

Rodante A. Roldan

Keyword(s):

Neck Dissection ◽

Cancer Patients ◽

Laryngeal Cancer ◽

Laryngeal Carcinoma ◽

Public Hospital ◽

Neck Node ◽

Cancer Metastases ◽

Level Ii ◽

Node Metastases ◽

Level I

Objective: To determine the patterns of neck node metastases of patients with laryngeal carcinoma in our institution. Methods: Design: Chart Review Setting: Tertiary Public Hospital Subjects: Records of thirty-eight (38) laryngeal cancer patients who underwent laryngectomy with neck dissection from January 2010 to January 2017 were considered. Results: Records of 34 laryngeal cancer patients with ages ranging from 45-72 years old were included. The most common subsite was the glottis, with 19 (55.88%) patients. The distribution of neck node metastases for all subsites were 0/64 (0%) for level I, 22/64 (34.37%) for level II, 12/64 (18.75%) for level III, 7/64 (10.93%) for level IV, 0/64 (0%) for level V, and 1/64 (1.56%) for level VI. Distributions of lymph nodes per subsite for supraglottic SCCA were 0 (0%) for level I, 3/22 (13.63%) for level II, 2/12 (16.66%) for level III, 1/7 (14.28%) for level IV, 0 (0%) for level V, and 0/1 (0%) for level VI. For glottic SCCA, they were 0 (0%) for level I, 12/22 (54.54%) for level II, 8/12 (66.66%) for level III, 3/7 (42.85%) for level IV, 0 (0%) for level V, and 1/1 (100%) for level VI; and for transglottic SCCA, they were 0 (0%) for level I, 7/22 (31.81%) for level II, 5/12 (41.66%) for level III, 3/7 (42.85%) for level IV, 0 (0%) for level V, and 0/1 (0%) for level VI. Conclusion: Our findings show that neck node levels II, III, and IV are most frequently affected in laryngeal carcinoma patients in our sample, and may guide recommendations for neck dissection in our institution. Keywords: Laryngeal Cancer, Metastases, Neck dissection, Supraglottic, Subglottic, Glottic, Transglottic

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Effect of an individualized food‐based nutritional intervention on serum vitamin A, E, and carotenoids concentrations in recently diagnosed breast cancer patients

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.04109 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Jessica Avila Prado ◽

Diana G. Salcido-Sauceda ◽

Ana T. Limon Miro ◽

Bertha I. Pacheco Moreno ◽

Humberto Astiazaran Garcia ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin A ◽

Cancer Patients ◽

Serum Vitamin ◽

Nutritional Intervention ◽

Breast Cancer Patients

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Serum vitamin A, E and C status in cervical cancer patients undergoing Concurrent Chemo-Radiotherapy, an institutional study

Journal of Nutrition & Intermediary Metabolism ◽

10.1016/j.jnim.2019.100107 ◽

2019 ◽

Vol 18 ◽

pp. 100107

Author(s):

Anju Shrivastava ◽

Satyajit Pradhan ◽

Surendra Pratap Mishra ◽

Anupam Kumar Asthana ◽

Sunil Choudhary ◽

...

Keyword(s):

Cervical Cancer ◽

Vitamin A ◽

Cancer Patients ◽

Serum Vitamin

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Serum Level of Vitamin A in Breast Cancer Patients and Apparently Healthy Women of Lahore, Pakistan

10.53350/pjmhs211592189 ◽

2021 ◽

Vol 15 (9) ◽

pp. 2189-2192

Author(s):

Mahwish Shahzad ◽

Bushra Iftikhar ◽

Mehwish Iftikhar ◽

Sadia Nazeer ◽

Rabia Akhtar Cheema

Keyword(s):

Breast Cancer ◽

Serum Level ◽

Vitamin A ◽

Cancer Patients ◽

Reference Values ◽

Serum Vitamin ◽

Breast Cancer Patients ◽

Healthy Women ◽

Number Of Patients ◽

Apparently Healthy

Background: Breast cancer is the second leading cause of death among women worldwide. In Asia, Pakistan has the highest number of patients of breast cancer. Chronic inflammation and hormonal imbalances contribute to the redox disruption thus increasing ROS that changes gene expression resulting in carcinogenesis. Antioxidants like Vitamin A may help reduce tissue-level inflammation through different mechanisms by maintaining redox balance within the tissue. Methods: This cross sectional comparative study was used to measure the serum level of vitamin A in breast cancer patients and in apparently healthy women of same age group to determine the involvement, if any, of this vitamin in breast cancer etiology. Out of 90 women that were recruited, 60 were breast cancer patients and 30 were apparently healthy women. Results: Vitamin A level in serum was measured by Enzyme Linked Immunosorbant Assay (ELISA). Serum vitamin A level was lower than the WHO reference values (30-90μg/dl) in all patients (18.62±4.43μg/dl) and apparently healthy women (19.59±3.40μg/dl). Although no difference was seen between patients and controls (p=0.274), nevertheless, more women (28.3%) were severely deficient in vitamin A than normal (6.7%) women. Increase in age significantly decreased vitamin A in both normal and breast cancer patients. Vitamin A level in serum was generally low, when matched with international reference values in patients than apparently healthy women. Conclusion: It is concluded that deficiency of vitamin A might lead to metabolic disturbances that can contribute to the development of cancers like breast cancer. Keywords: breast cancer, ROS, vitamin A, anti oxidants

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Microbiota in the Throat and Risk Factors for Laryngeal Carcinoma

Applied and Environmental Microbiology ◽

10.1128/aem.02329-14 ◽

2014 ◽

Vol 80 (23) ◽

pp. 7356-7363 ◽

Cited By ~ 21

Author(s):

Hongli Gong ◽

Yi Shi ◽

Xia Zhou ◽

Chunping Wu ◽

Pengyu Cao ◽

...

Keyword(s):

Spatial Structure ◽

Cancer Patients ◽

Laryngeal Cancer ◽

Laryngeal Carcinoma ◽

16S Rrna Genes ◽

Rrna Genes ◽

Tissue Samples ◽

Content Type ◽

Control Subjects ◽

And Control

ABSTRACTThe compositions and abundances of the microbiota in the ecological niche of the human throat and the possible relationship between the microbiota and laryngeal cancer are poorly understood. To obtain insight into this, we enrolled 27 laryngeal carcinoma patients and 28 subjects with vocal cord polyps as controls. For each subject, we simultaneously collected swab samples from the upper throat near the epiglottis (site I) and tissue samples from the vestibulum laryngis to the subglottic region (site II). The microbiota of the throat were fully characterized by pyrosequencing of barcoded 16S rRNA genes. We found 14 phyla, 20 classes, 38 orders, 85 families, and 218 genera in the throats of enrolled subjects. The main phyla wereFirmicutes(54.7%),Fusobacteria(14.8%),Bacteroidetes(12.7%), andProteobacteria(10.6%).Streptococcus(37.3%),Fusobacterium(11.3%), andPrevotella(10.6%) were identified as the three most predominant genera in the throat. The relative abundances of 23 bacterial genera in site I were significantly different from those in site II (P< 0.05). The relative proportions of 12 genera largely varied between laryngeal cancer patients and control subjects (P< 0.05). Collectively, this study outlined the spatial structure of microbial communities in the human throat. The spatial structure of bacterial communities significantly varied in two anatomical sites of the throat. The bacterial profiles of the throat of laryngeal cancer patients were strongly different from those of control subjects, and several of these microorganisms may be related to laryngeal carcinoma.

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Serum Vitamin A, E and Carotenoids After 6 Months of an Individualized Nutritional Intervention in Recently Diagnosed Breast Cancer Patients

Current Developments in Nutrition ◽

10.1093/cdn/nzaa044_005 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 306-306

Author(s):

Jessica Avila-Prado ◽

Veronica Lopez-Teros ◽

Ana Limon-Miro ◽

Diana Salcido Sauceda ◽

Bertha I Pacheco-Moreno ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin A ◽

Cancer Patients ◽

Intervention Program ◽

Serum Vitamin ◽

Nutritional Intervention ◽

Nutrition Intervention ◽

Breast Cancer Patients ◽

Serum Retinol ◽

Antineoplastic Treatment

Abstract Objectives The aim of this study was to evaluate serum concentrations of retinol, carotenoids and α-tocopherol before and after 6 mo of an individualized nutrition intervention program in recently diagnosed breast cancer patients (BCP). Methods This is a pretest-posttest study in recently diagnosed nonmetastatic BPC undergoing antineoplastic treatment. Baseline and final measurements include anthropometry, body composition (dual x-ray absorptiometry), 24 h dietary recall, and the assessment of serum retinol, carotenoids and α-tocopherol. The individualized nutrition intervention was developed based on the macronutrient meal equivalent method, based on women's total energy expenditure, and following the WCRF/AICR guidelines, adapting 1.5 g/kg/d of protein intake, 5–9 servings of fruits and vegetables and a caloric restriction (500–1000 kcal/d) when applicable (BMI ≥ 25 kg/m2). Results Nineteen women between 33 and 68 years of age completed the intervention. At the time of diagnosis, 74% of the women were overweight or obese, and serum retinol was < 1.05 µmol/L in 42% (n = 8). After the intervention, BCP decreased an average of 2.67 kg of body weight (p < 0.001), and lost ∼2 kg of body fat (p < 0.01). After the intervention, serum retinol increased + 0.83 µmol/L (p < 0.001) and α-tocopherol increased + 1.89 µmol/L (p < 0.02) increased, which was positively correlated with a dietary increase of these micronutrients (p < 0.05). No difference was found for provitamin A carotenoids or xantophils (α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene) (p > 0.05). Conclusions The implementation of an individualized nutritional intervention program before and during antineoplastic treatment increased serum vitamin A and E concentration, improving the nutritional status of BCP. This trial was registered at clinicaltrials.gov as NCT03625635. Funding Sources JAP, ATLM received a fellowship from the National Research Council in Mexico.

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