The relationship of plasma Aβ levels to dementia in aging individuals with mild cognitive impairment

ABSTRACT Mild cognitive decline is a feared aspect of aging associated with frailty experienced by individuals. Objective: To determine the number of elderly people with mild cognitive impairment (MCI); to determine the relationship of sociodemographic and clinical variables by group of individuals with or without MCI and to determine the relationship between MCI assessed by 6CIT and the cognitive domains assessed by the MoCA. Methods: A correlational study was conducted of 44 elderly individuals attending a day-care center or residing in a care home, with an average age of 88.9 ± 8.8 years who answered a structured interview collecting sociodemographic and clinical data. Results: The elderly living at home had higher average body mass index and number of pathologies than those living in an institution for the elderly (p < 0.01). 63.6% of the elderly did not have MCI, and no differences were found between residential settings. The comparison between 6CIT and MoCA yielded differences in the general domain and in visual, attention, abstraction and, orientation subdomains. Conclusion: Cognitive stimulation interventions should be optimized according to the residential setting at the level of comorbidities and nutrition.

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The Dyad Dilemma: Strategies to Recruit Study Partners for Mild Cognitive Impairment Clinical Trials

Innovation in Aging ◽

10.1093/geroni/igab046.123 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 33-34

Author(s):

Allison Gibson ◽

Caitlin Pope ◽

Elizabeth Rhodus ◽

Kelly Parsons ◽

Julia Johnson ◽

...

Keyword(s):

Clinical Trial ◽

Clinical Trials ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Decline ◽

Thematic Analysis ◽

Inclusion Criteria ◽

Effective Strategies ◽

Relationship Of ◽

The Relationship

Abstract Mild cognitive impairment (MCI) research faces challenges to successful enrollment, especially with clinical trial studies. This study explores researchers’ experiences recruiting from a U.S. Alzheimer’s Disease Center for a pilot, platform trial of biopsychosocial interventions for MCI dyads. Individuals with MCI that met the inclusion criteria for the study were invited to participate (n=39). Thematic analysis of recruitment case notes was utilized to track participants’ and study partners’ interest in participation. In most cases, participants with MCI were interested and willing to enroll and study partners were not. Recruiting persons with MCI and their study partners for clinical trials research may require specialized communication messaging such as education about how interventions address the needs of MCI, along with training on the relationship of MCI to cognitive decline. This presentation highlights effective strategies to engage study partners into recruitment for MCI research such as creating more flexible participation roles and offerings.

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Lower functional hippocampal redundancy in mild cognitive impairment

Translational Psychiatry ◽

10.1038/s41398-020-01166-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Stephanie Langella ◽

◽

Muhammad Usman Sadiq ◽

Peter J. Mucha ◽

Kelly S. Giovanello ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Decline ◽

Resting State ◽

Memory Performance ◽

Potential Mechanism ◽

Network Efficiency ◽

Cognitively Normal ◽

Normal Individuals ◽

The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

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Relationship of tooth loss to mild cognitive impairment among middle-aged Mongolians: Mon-timeline study

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.119731 ◽

2021 ◽

Vol 429 ◽

pp. 119731

Author(s):

Urangoo Ganbaatar ◽

Uuganzaya Erdeneochir ◽

Puntsagdulam Byambajav ◽

Tsolmon Jadamba ◽

Oyuntugs Byambasukh ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Tooth Loss ◽

Middle Aged ◽

Relationship Of

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Impact of Design on Emotional, Psychological, or Social Well-Being for People With Cognitive Impairment

HERD Health Environments Research & Design Journal ◽

10.1177/1937586718813194 ◽

2018 ◽

Vol 12 (3) ◽

pp. 220-232 ◽

Cited By ~ 4

Author(s):

Elizabeth Karol ◽

Dianne Smith

Keyword(s):

Quality Of Life ◽

Cognitive Impairment ◽

Literature Review ◽

Thermal Comfort ◽

Well Being ◽

Design Expertise ◽

Relationship Of ◽

The Impact ◽

The Relationship

Aim:The objective of this article is to identify and analyze what is known about characteristics in and around the home that support well-being for those with cognitive impairment. This could provide direction for designers of homes in general, but specifically for designers trying to meet the needs of people with cognitive impairment.Background:It has been established that there is a relationship between psychological well-being and a person’s environment. Research also shows that particular design aspects can reduce the impact of cognitive impairment. However, there is limited design expertise in the Australian housing market to create supportive spaces which will help to reduce the impact of the disability for those with cognitive impairment.Method:A literature review was carried out to determine the extent and details of what is known about the relationship of home design and its impact on emotional, psychological, or social well-being for people with cognitive impairment.Conclusions:The study indicates that researchers in various disciplines understand that pragmatic design inputs such as thermal comfort and adequate lighting are important for people with cognitive impairment. In addition, some researchers have shown or surmise that there are other “intangible” designer-controlled elements that have beneficial impacts on people with cognitive impairment. Details of these intangible elements are sparse, and how much they might improve the quality of life for a person with cognitive impairment is not well understood. Further research is required to meet a growing need.

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