Role of neurospecific proteins in the pathogenesis of Parkinsonism syndrome development in chronic brain ischemia

The aim: A correction of cholinergic insufficiency for the treatment of cognitive impairment in chronic brain ischemia. Materials and methods: In the period 2014 – 2017, 88 people aged 40 to 68 years were comprehensively examined in dynamics. Patients were divided into three groups, statistically comparable to the main disease – CCI 2 degrees, gender and age. In addition to the protocol, patients with discirculatory encephalopathy of all the investigated groups received a complex of drugs aimed at correcting neurotransmitter metabolism. Results: The statistically significant manifestations of the recovery of cognitive function (according to the MMSE scale) after the application of the developed complex therapy were associated mainly with a decrease in impulsivity due to an increase in the level of attention. The statistically significant manifestations of a decrease in the level of anxietydepressive disorders (according to the DASS-21 scale) after the application of the developed complex therapy were associated mainly with a decrease in anxiety due to the restoration of neurohumoral balance. Conclusions: The inclusion in the treatment protocol for CCI complex of drugs aimed at eliminating cholinergic deficiency, acetylcholinesterase inhibitors in combination with choline precursors, leads to the correction of cognitive impairment in chronic brain ischemia.

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THE USE OF ALTERNATIVE AND CLASSICAL TECHNOLOGIES IN THE REHABILITATION OF PATIENTS WITH CHRONIC BRAIN ISCHEMIA

Fitoterapia ◽

10.33617/2522-9680-2019-2-44 ◽

2019 ◽

Vol 2 (2) ◽

pp. 44-45

Author(s):

L. V. Andriyuk ◽

◽

A. V. Yermolaieva ◽

N. V. Matsko ◽

O. V. Grabous ◽

...

Keyword(s):

Brain Ischemia ◽

Chronic Brain Ischemia

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Prevalence and severity of depression in patients with the consequences of ischemic strokes and in patients with chronic brain ischemia

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.10.030 ◽

2021 ◽

Vol 11 (10) ◽

pp. 320-324

Author(s):

A. Babirad

Keyword(s):

Cerebral Ischemia ◽

Brain Ischemia ◽

Rating Scale ◽

Severe Depression ◽

Chronic Cerebral Ischemia ◽

Mild Depression ◽

Hamilton Depression Rating Scale ◽

Chronic Brain Ischemia ◽

Severity Of Depression

The aim of our study was to investigate the prevalence and severity of depression in patients with the consequences of ischemic strokes and in patients with chronic brain ischemia. Material and Methods. We examined 100 patients with consequences of ischemic strokes and 17 patients with chronic cerebral ischemia. The Hamilton Depression Rating Scale was used to assess the presence and degree of depression. Conclusions. Slightly less than half of the patients with chronic cerebral ischemia (47.1%) had no depression, 42.1% had mild depression, and only 11.8% of the patients had moderate and severe depression. A different situation was observed in the group of patients with the consequences of ischemic strokes. Among them, only 22.0% of patients had no depression, 44.0% had mild depression, and 34.0% of patients had moderate, severe, and extremely severe depression (p < 0.05).

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