High resolution ultrasound shows axonal degeneration of the vagus nerve in idiopathic Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 119443
Author(s):  
Ferdinando Sartucci ◽  
Tommaso Bocci ◽  
Michela Santin ◽  
Bongioanni Paolo ◽  
Giovanni Orlandi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Resolution ◽  
Vagus Nerve ◽  
Axonal Degeneration ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease

scholarly journals High-resolution ultrasound changes of the vagus nerve in idiopathic Parkinson’s disease (IPD): a possible additional index of disease

2021 ◽  
Author(s):  
F. Sartucci ◽  
T. Bocci ◽  
M. Santin ◽  
P. Bongioanni ◽  
G. Orlandi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Resolution ◽  
Vagus Nerve ◽  
Imaging Modality ◽  
Disease Stage ◽  
Motor Nucleus ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease ◽  
Additional Index

Abstract Background and rationale Histopathological studies revealed degeneration of the dorsal motor nucleus of the vagus nerve (VN) early in the course of idiopathic Parkinson’s disease (IPD). Degeneration of VN axons should be detectable by high-resolution ultrasound (HRUS) as a thinning of the nerve trunk. In order to establish if the VN exhibits sonographic signs of atrophy in IPD, we examined patients with IPD compared with age-matched controls. Material and methods We measured the caliber (cross-sectional area, CSA) and perimeter of the VN in 20 outpatients with IPD (8 females and 12 males; mean age 73.0 + 8.6 years) and in age-matched controls using HRUS. Evaluation was performed by blinded raters using an Esaote MyLab Gamma device in conventional B-Mode with an 8–19 MHz probe. Results In both sides, the VN CSA was significantly smaller in IPD outpatients than in controls (right 2.37 + 0.91, left 1.87 + 1.35 mm2 versus 6.0 + 1.33, 5.6 + 1.26 mm2; p <0.001), as well as the perimeter (right 5.06 + 0.85, left 4.78 + 1.74 mm versus 8.87 + 0.86, 8.58 + 0.97 mm; p <0.001). There were no significant correlations between VN CSA and age, the Hoehn and Yahr scale, L-dopa therapy, and disease duration. Conclusion Our findings provide evidence of atrophy of the VNs in IPD patients by HRUS. Moreover, HRUS of the VN represent a non-invasive easy imaging modality of screening in IPD patients independent of disease stage and duration and an interesting possible additional index of disease.

Detection of retinal changes in idiopathic Parkinson's disease using high-resolution optical coherence tomography and heidelberg retina tomography

2015 ◽  
Vol 93 (7) ◽  
pp. e578-e584 ◽  
Author(s):  
Diana Bittersohl ◽  
Birthe Stemplewitz ◽  
Matthias Keserü ◽  
Carsten Buhmann ◽  
Gisbert Richard ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optical Coherence Tomography ◽  
High Resolution ◽  
Optical Coherence ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease

scholarly journals Axonal Degeneration of the Vagus Nerve in Parkinson's Disease—A High-Resolution Ultrasound Study

2018 ◽  
Vol 9 ◽  
Author(s):  
Johann Otto Pelz ◽  
Elena Belau ◽  
Christopher Fricke ◽  
Joseph Classen ◽  
David Weise
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Resolution ◽  
Vagus Nerve ◽  
Axonal Degeneration ◽  
Ultrasound Study
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