Short- and long-term motor outcome of STN-DBS in Parkinson's disease: Focus on gender differences

2021 ◽  
Vol 429 ◽  
pp. 119560
Author(s):  
Nico Golfrè Andreasi ◽  
Roberta Telese ◽  
Luigi Romito ◽  
Roberto Cilia ◽  
Antonio Elia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gender Differences ◽  
Parkinson's Disease ◽  
Motor Outcome ◽  
Short And Long Term ◽  
Disease Focus ◽  
Stn Dbs

Short- and long-term motor outcome of STN-DBS in Parkinson’s Disease: focus on sex differences

2021 ◽  
Author(s):  
Nico Golfrè Andreasi ◽  
Luigi Michele Romito ◽  
Roberta Telese ◽  
Roberto Cilia ◽  
Antonio Emanuele Elia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sex Differences ◽  
Motor Outcome ◽  
Short And Long Term ◽  
Disease Focus ◽  
Stn Dbs

scholarly journals Short- and Long-Term Effects of DBS on Gait in Parkinson's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Hana Brozova ◽  
Isabelle Barnaure ◽  
Evzen Ruzicka ◽  
Jan Stochl ◽  
Ron Alterman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Repeated Measures ◽  
Rating Scale ◽  
Long Term Effects ◽  
Short Term ◽  
Short And Long Term ◽  
Mean Time ◽  
Stn Dbs

The aim was to compare the short and long-term effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait dysfunction and other cardinal symptoms of Parkinson's disease (PD). Two groups of patients were studied. The first group (short-term DBS, n = 8) included patients recently implanted with STN DBS (mean time since DBS 15.8 months, mean age 58.8 years, PD duration 13 years); the second group (long-term DBS, n = 10) included patients with at least 5 years of DBS therapy (mean time since DBS 67.6 months, mean age 61.7 years, PD duration 17.1 years). Both groups were examined using the Unified Parkinson's Disease Rating Scale (UPDRS) and Gait and Balance scale (GABS) during four stimulation/medication states (ON/OFF; OFF/OFF; OFF/ON; ON/ON). Data were analyzed using repeated measures ANOVA with time since implantation (years) between groups and medication or DBS effect (ON, OFF) within groups. In the short-term DBS group, stimulation improved all UPDRS subscores similar to dopaminergic medications. In particular, average gait improvement was over 40% (p = 0.01), as measured by the UPDRS item 29 and GABS II. In the long-term DBS group, stimulation consistently improved all clinical subscores with the exception of gait and postural instability. In these patients, the effect of levodopa on gait was partially preserved. Short-term improvement of gait abnormalities appears to significantly decline after 5 years of STN DBS in PD patients, while effectiveness for other symptoms remains stable. Progressive non-dopaminergic (non-DBS responsive) mechanisms or deleterious effects of high frequency STN stimulation on gait function may play a role.

Short- and long-term effects induced by repeated 6-OHDA intraventricular administration: A new progressive and bilateral rodent model of Parkinson’s disease

Neuroscience ◽  
2017 ◽  
Vol 361 ◽  
pp. 144-156 ◽  
Author(s):  
A. Quiroga-Varela ◽  
E. Aguilar ◽  
E. Iglesias ◽  
J.A. Obeso ◽  
C. Marin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rodent Model ◽  
Intraventricular Administration ◽  
Long Term Effects ◽  
Short And Long Term

scholarly journals Longitudinal prediction of falls and near falls frequencies in Parkinson’s disease: a prospective cohort study

2020 ◽  
Author(s):  
Beata Lindholm ◽  
Christina Brogårdh ◽  
Per Odin ◽  
Peter Hagell
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Cohort ◽  
Prediction Models ◽  
Evidence Base ◽  
History Of ◽  
Short And Long Term ◽  
Near Falls ◽  
Short Time

Abstract Introduction and objective Several prediction models for falls/near falls in Parkinson’s disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- and long-term predictors of the number of falls/near falls in PD. Methods A prospective cohort of 58 persons with PD was assessed at baseline (mean age and PD duration, 65 and 3.2 years, respectively) and 3.5 years later. Potential predictors were history of falls and near falls, comfortable gait speed, freezing of gate, dyskinesia, retropulsion, tandem gait (TG), pain, and cognition (Mini-Mental State Exam, MMSE). After each assessment, the participants registered a number of falls/near falls during the following 6 months. Multivariate Poisson regression was used to identify short- and long-term predictors of a number of falls/near falls. Results Baseline median (q1–q3) motor (UPDRS) and MMSE scores were 10 (6.75–14) and 28.5 (27–29), respectively. History of falls was the only significant short-time predictor [incidence rate ratio (IRR), 15.17] for the number of falls/near falls during 6 months following baseline. Abnormal TG (IRR, 3.77) and lower MMSE scores (IRR, 1.17) were short-term predictors 3.5 years later. Abnormal TG (IRR, 7.79) and lower MMSE scores (IRR, 1.49) at baseline were long-term predictors of the number of falls/near falls 3.5 years later. Conclusion Abnormal TG and MMSE scores predict the number of falls/near falls in short and long term, and may be indicative of disease progression. Our observations provide important additions to the evidence base for clinical fall prediction in PD.

Long-term cognitive profile and incidence of dementia after STN-DBS in Parkinson's disease

2007 ◽  
Vol 22 (7) ◽  
pp. 974-981 ◽  
Author(s):  
Selma Aybek ◽  
Aline Gronchi-Perrin ◽  
Alexandre Berney ◽  
Sabina Catalano Chiuvé ◽  
Jean-Guy Villemure ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Profile ◽  
Stn Dbs ◽  
Incidence Of Dementia

Intensive speech treatment for patients with Parkinson's disease: Short- and long-term comparison of two techniques

Neurology ◽  
1996 ◽  
Vol 47 (6) ◽  
pp. 1496-1504 ◽  
Author(s):  
L. O. Ramig ◽  
S. Countryman ◽  
C. O'Brien ◽  
M. Hoehn ◽  
L. Thompson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Short And Long Term ◽  
Speech Treatment

scholarly journals 220 SHORT- AND LONG-TERM EFFECTS OF DBS ON GAIT IN PARKINSON'S DISEASE

2010 ◽  
Vol 16 ◽  
pp. S63
Author(s):  
H. Brozova ◽  
I. Barnaure ◽  
E. Ruzicka ◽  
J. Stochl ◽  
R. Alterman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Effects ◽  
Short And Long Term

Long-term effect of bilateral STN-DBS on non-motor symptoms in Parkinson’s disease: a four-year observational, prospective study

2021 ◽  
Author(s):  
Dejan Georgiev ◽  
Maruša Mencinger ◽  
Robert Rajnar ◽  
Polona Mušič ◽  
Mitja Benedičič ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Study ◽  
Term Effect ◽  
Motor Symptoms ◽  
Observational Prospective Study ◽  
Long Term Effect ◽  
Non Motor Symptoms ◽  
Stn Dbs

Selegiline and levodopa in early or moderately advanced Parkinson's disease: a double-blind controlled short- and long-term study

1989 ◽  
Vol 80 ◽  
pp. 147-152 ◽  
Author(s):  
B. Sivertsen ◽  
E. Dupont ◽  
B. Mikkelsen ◽  
P. Mogensen ◽  
C. Rasmussen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Term Study ◽  
Double Blind ◽  
Advanced Parkinson’S Disease ◽  
Long Term Study ◽  
Short And Long Term
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