scholarly journals Short- and Long-Term Effects of DBS on Gait in Parkinson's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Hana Brozova ◽  
Isabelle Barnaure ◽  
Evzen Ruzicka ◽  
Jan Stochl ◽  
Ron Alterman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Repeated Measures ◽  
Rating Scale ◽  
Long Term Effects ◽  
Short Term ◽  
Short And Long Term ◽  
Mean Time ◽  
Stn Dbs

The aim was to compare the short and long-term effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait dysfunction and other cardinal symptoms of Parkinson's disease (PD). Two groups of patients were studied. The first group (short-term DBS, n = 8) included patients recently implanted with STN DBS (mean time since DBS 15.8 months, mean age 58.8 years, PD duration 13 years); the second group (long-term DBS, n = 10) included patients with at least 5 years of DBS therapy (mean time since DBS 67.6 months, mean age 61.7 years, PD duration 17.1 years). Both groups were examined using the Unified Parkinson's Disease Rating Scale (UPDRS) and Gait and Balance scale (GABS) during four stimulation/medication states (ON/OFF; OFF/OFF; OFF/ON; ON/ON). Data were analyzed using repeated measures ANOVA with time since implantation (years) between groups and medication or DBS effect (ON, OFF) within groups. In the short-term DBS group, stimulation improved all UPDRS subscores similar to dopaminergic medications. In particular, average gait improvement was over 40% (p = 0.01), as measured by the UPDRS item 29 and GABS II. In the long-term DBS group, stimulation consistently improved all clinical subscores with the exception of gait and postural instability. In these patients, the effect of levodopa on gait was partially preserved. Short-term improvement of gait abnormalities appears to significantly decline after 5 years of STN DBS in PD patients, while effectiveness for other symptoms remains stable. Progressive non-dopaminergic (non-DBS responsive) mechanisms or deleterious effects of high frequency STN stimulation on gait function may play a role.

Short- and long-term motor outcome of STN-DBS in Parkinson's disease: Focus on gender differences

2021 ◽  
Vol 429 ◽  
pp. 119560
Author(s):  
Nico Golfrè Andreasi ◽  
Roberta Telese ◽  
Luigi Romito ◽  
Roberto Cilia ◽  
Antonio Elia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gender Differences ◽  
Parkinson's Disease ◽  
Motor Outcome ◽  
Short And Long Term ◽  
Disease Focus ◽  
Stn Dbs

scholarly journals 220 SHORT- AND LONG-TERM EFFECTS OF DBS ON GAIT IN PARKINSON'S DISEASE

2010 ◽  
Vol 16 ◽  
pp. S63
Author(s):  
H. Brozova ◽  
I. Barnaure ◽  
E. Ruzicka ◽  
J. Stochl ◽  
R. Alterman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Effects ◽  
Short And Long Term

Short- and long-term motor outcome of STN-DBS in Parkinson’s Disease: focus on sex differences

2021 ◽  
Author(s):  
Nico Golfrè Andreasi ◽  
Luigi Michele Romito ◽  
Roberta Telese ◽  
Roberto Cilia ◽  
Antonio Emanuele Elia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sex Differences ◽  
Motor Outcome ◽  
Short And Long Term ◽  
Disease Focus ◽  
Stn Dbs

A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson's Disease

2015 ◽  
Vol 43 (03) ◽  
pp. 407-423 ◽  
Author(s):  
Fang-Pey Chen ◽  
Ching-Mao Chang ◽  
Jing-Huei Shiu ◽  
Jen-Hwey Chiu ◽  
Ta-Peng Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Western Medicine ◽  
Rating Scale ◽  
Acupuncture Treatment ◽  
Complementary Therapy ◽  
Control Group ◽  
Short Term ◽  
Long Time

Complementary therapy with acupuncture for Parkinson's disease (PD) has been studied for quite a long time, but the effectiveness of the treatment still remains unclear. The aim of this study is to evaluate the integrated effects of acupuncture treatment in PD patients who received western medicine. In the short-term acupuncture treatment study, 20 patients received acupuncture therapy twice a week in acupoints DU 20, GB 20, LI 11, LI 10, LI 4, GB 31, ST 32, GB 34 and GB 38 along with western medicine for 18 weeks, and 20 controlled patients received western medicine only. In the long-term acupuncture treatment, 13 patients received acupuncture treatment twice a week for 36 weeks. The outcome parameters include Unified Parkinson's disease rating scale (UPDRS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-Version 2 (BDI-II), and WHO quality of life (WHOQOL). In the short-term clinical trial, a higher percentage of patients in the acupuncture group had score improvement in UPDRS total scores (55% vs. 15%, p = 0.019), sub-score of mind, behavior and mood (85% vs. 25%, p < 0.001), activity of daily living (65% vs. 15%, p = 0.003), mobility (40% vs. 15%, p = 0.155) and complication of treatment (75% vs. 15%, p < 0.001), BDI-II score (85% vs. 35%, p = 0.003), and WHOQOL score (65% vs. 15%, p = 0.003) when compared to control group at the end of the 18 weeks' follow up. After 36 weeks of long-term acupuncture treatment, the mean UPDRS total scores and sub-score of mentation, behavior and mood, sub-score of complications of therapy and BDI-II score decreased significantly when compared to the pretreatment baseline. In conclusion, acupuncture treatment had integrated effects in reducing symptoms and signs of mind, behavior, mood, complications of therapy and depression in PD patients who received Western medicine.

scholarly journals Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial

2021 ◽  
pp. 154596832110231
Author(s):  
Kishoree Sangarapillai ◽  
Benjamin M. Norman ◽  
Quincy J. Almeida
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Controlled Trial ◽  
Repeated Measures ◽  
Rating Scale ◽  
Controlled Trial ◽  
Motor Symptoms ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Double Blinded

Background. Exercise is increasingly becoming recognized as an important adjunct to medications in the clinical management of Parkinson’s disease (PD). Boxing and sensory exercise have shown immediate benefits, but whether they continue beyond program completion is unknown. This study aimed to investigate the effects of boxing and sensory training on motor symptoms of PD, and whether these benefits remain upon completion of the intervention. Methods. In this 20-week double-blinded randomized controlled trial, 40 participants with idiopathic PD were randomized into 2 treatment groups, (n = 20) boxing or (n = 20) sensory exercise. Participants completed 10 weeks of intervention. Motor symptoms were assessed at (week 0, 10, and 20) using the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Data were analyzed using SPSS, and repeated-measures ANOVA was conducted. Results. A significant interaction effect between groups and time were observed F(1, 39) = 4.566, P = .036, where the sensory group improved in comparison to the boxing group. Post hoc analysis revealed that in comparison to boxing, the effects of exercise did not wear off at washout (week 20) P < .006. Conclusion. Future rehabilitation research should incorporate similar measures to explore whether effects of exercise wear off post intervention.

Nationwide Multicenter Prospective Study on the Long-Term Effects of Bromocriptine for Parkinson's Disease

1997 ◽  
Vol 38 (2) ◽  
pp. 37-49 ◽  
Author(s):  
Norio Ogawa ◽  
Ichiro Kanazawa ◽  
Hisayuki Kowa ◽  
Sadako Kuno ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Study ◽  
Long Term Effects ◽  
Multicenter Prospective Study
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