Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells

2013 ◽  
Vol 24 (11) ◽  
pp. 1849-1858 ◽  
Author(s):  
Minami Kumazaki ◽  
Shunsuke Noguchi ◽  
Yuki Yasui ◽  
Junya Iwasaki ◽  
Haruka Shinohara ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Mirna Expression ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Human Colon Cancer Cells

scholarly journals Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone

Oncogene ◽  
2000 ◽  
Vol 19 (36) ◽  
pp. 4125-4133 ◽  
Author(s):  
Paul A Clarke ◽  
Isabelle Hostein ◽  
Udai Banerji ◽  
Francesca Di Stefano ◽  
Alison Maloney ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Molecular Chaperone ◽  
Expression Profiling ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Abstract 5047: Synergistic anti-cancer activity of the CDK4/6 inhibitor PD-0332991 in combination with 5-fluorouracil-based chemotherapy in human colon cancer cells

2010 ◽  
Author(s):  
Michael J. Pishvaian ◽  
Shaoxian Yang ◽  
Majed El Zouhairi ◽  
Christina S. Wu ◽  
Lopa Mishra ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells ◽  
Cancer Activity

Perturbation by Geraniol of Cell Membrane Permeability and Signal Transduction Pathways in Human Colon Cancer Cells

2002 ◽  
Vol 303 (2) ◽  
pp. 711-715 ◽  
Author(s):  
S. Carnesecchi ◽  
A. Bradaia ◽  
B. Fischer ◽  
D. Coelho ◽  
M. Schöller-Guinard ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Cell Membrane ◽  
Cancer Cells ◽  
Human Colon ◽  
Cell Membrane Permeability ◽  
Signal Transduction Pathways ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals UDP-Glucuronosyltransferase 1A Compromises Intracellular Accumulation and Anti-Cancer Effect of Tanshinone IIA in Human Colon Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79172 ◽  
Author(s):  
Miao Liu ◽  
Qiong Wang ◽  
Fang Liu ◽  
Xuefang Cheng ◽  
Xiaolan Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Tanshinone Iia ◽  
Colon Cancer Cells ◽  
Intracellular Accumulation ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Udp Glucuronosyltransferase ◽  
Human Colon Cancer Cells

scholarly journals Effects of Silymarin-Loaded Nanoparticles on HT-29 Human Colon Cancer Cells

Medicina ◽  
2018 ◽  
Vol 54 (1) ◽  
pp. 1 ◽  
Author(s):  
Maryam Mombeini ◽  
Ghasem Saki ◽  
Layasadat Khorsandi ◽  
Neda Bavarsad
Keyword(s):  
Colon Cancer ◽  
Toxic Effect ◽  
Cancer Cells ◽  
Cancer Cell Line ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells ◽  
Ht 29

Background and objective: Previous studies have demonstrated the anti-cancer effects of silymarin (SLM). However, the low bioavailability of SLM has restricted its use. This study investigated the toxic effect of nanostructured SLM encapsulated in micelles (Nano-SLM) on the growth of the HT-29 human colon cancer cell line. Materials and methods: HT-29 cells were treated with 25 μM/mL of SLM or Nano-SLM for 48 h. MTT and colony formation assays were used to assess the cytotoxicity and proliferation of HT-29 cells, respectively. The cells were stained with annexin V/PI for assessment of apoptosis. Results: MTT assays revealed that Nano-SLM treatment was able to exert a more pronounced toxic effect on the HT-29 cells as compared to free SLM treatment (p < 0.01). In the Nano-SLM-treated cells, colony numbers were significantly reduced in comparison to the free SLM-treated cells (p < 0.01). Apoptotic and necrotic indexes of Nano-SLM-treated HT-29 cells were also significantly increased in comparison to those of the free SLM-treated cells (p < 0.01). The viability, proliferation and apoptosis of healthy cells (NIH-3T3 cells) were not changed in response to Nano-SLM or SLM. Conclusions: Our results indicate that Nano-SLM enhances the anti-cancer effects of SLM against human colon cancer cells.

scholarly journals ESE-1/ELF3 Is a Tumor Suppressor and Molecular Target of Green Tea Compound, EGCG (P05-009-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Taekyu Ha ◽  
Jihye Lee ◽  
Zhiyuan Lou ◽  
Bok-Soon Lee ◽  
Chul-Ho Kim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Nuclear Localization ◽  
Human Colon ◽  
Molecular Target ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells

Abstract Objectives Epithelial Specific ETS-1 (ESE-1), also known as E74-Like Factor 3 (ELF3), belongs to the E26 transformation-specific transcription factor superfamily and is of great interest as a potential target for managing several types of cancer. The objectives of this study are to investigate whether ESE-1/ELF3 is a tumor suppressor and to identify dietary anti-cancer compound to activate ESE-1/ELF3 expression in human colon cancer model. Methods The formation of aberrant crypt foci (ACF) was examined in wild type and ESE-1/ELF3 knockout mice exposed to combination of azoxymethane (AOM) and dextran sulfate sodium (DSS). Stable human colon cancer cell lines expressing ESE-1/ELF3 were established and used for xenograft study and in vitro mechanistic studies. Many bioactive phytochemicals were screened based on the activation of ESE-1/ELF3 expression. Results ESE-1/ELF3 knockout in mice increased AOM-induced and DSS-promoted formation of ACF. Conversely, overexpression of ESE-1/ELF3 suppressed tumorigenicity in a xenograft mouse study and repressed anchorage-independent growth and migration/invasion in human colon cancer cells. Full length ESE-1/ELF3 localized abundantly in the nucleus, and internal deletion of nuclear localization sequence 2 (NLS2) reduced nuclear ESE-1/ELF3. Three lysine residues (318KKK320) in the NLS2 determine its nuclear localization. We identified epigallocatechin-3-gallate (EGCG) that acts as a transcriptional activator of ESE-1/ELF3 in human colon cancer cells. Conclusions These findings propose a novel and promising molecular target of dietary anti-cancer compounds for prevention of colon cancer. Funding Sources American Cancer Society. Supporting Tables, Images and/or Graphs

scholarly journals ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells

2015 ◽  
Vol 23 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Kui-Jin Kim ◽  
Jihye Lee ◽  
Yeonhwa Park ◽  
Seong-Ho Lee
Keyword(s):  
Colon Cancer ◽  
Linoleic Acid ◽  
Cancer Cells ◽  
Conjugated Linoleic Acid ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells ◽  
Cancer Activity

Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (−)-epigallocatechin-3-gallate in human colon cancer cells

2020 ◽  
Vol 401 ◽  
pp. 115100 ◽  
Author(s):  
Zheyu Zhang ◽  
Sifang Zhang ◽  
Jingjing Yang ◽  
Pengji Yi ◽  
Panpan Xu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Cancer ◽  
Human Colon Cancer Cells
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