The objective of this study was to analyse retrieved human femoral bone samples using three different test
methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads
were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a
maximum of 24 hours postoperatively at + 6 °C to 8 °C.
Analysis revealed an average structural modulus of 232±130 N/mm2 and ultimate compression strength of 6.1±3.3 N/mm2 with high standard deviations. Bone mineral densities of 385±133 mg/cm2 and 353±172 mg/cm3 were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm3. In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22).
Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements.
Genetic association analysis of radiographic hip osteoarthritis with established loci for bone mineral density: data from the osteoarthritis initiative
