High Prevalence of Maternal Serum 25-Hydroxyvitamin D Deficiency Is Not Associated With Poor Birth Outcomes Among Healthy White Women in the Pacific Northwest

2019 ◽  
Vol 48 (2) ◽  
pp. 163-175
Author(s):  
Doria K. Thiele ◽  
Elise N. Erickson ◽  
Jonathan M. Snowden
2010 ◽  
Vol 140 (5) ◽  
pp. 999-1006 ◽  
Author(s):  
Lisa M. Bodnar ◽  
Janet M. Catov ◽  
Joseph M. Zmuda ◽  
Margaret E. Cooper ◽  
Meredith S. Parrott ◽  
...  

2015 ◽  
Vol 63 (S 03) ◽  
Author(s):  
F.E.A. Udink ten Cate ◽  
F. Holler ◽  
T. Hannes ◽  
I. Germund ◽  
M. Emmel ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3082
Author(s):  
Spyridon N. Karras ◽  
Erdinç Dursun ◽  
Merve Alaylıoğlu ◽  
Duygu Gezen-Ak ◽  
Cedric Annweiler ◽  
...  

Recent results indicate that dysregulation of vitamin D-binding protein (VDBP) could be involved in the development of hypovitaminosis D, and it comprises a risk factor for adverse fetal, maternal and neonatal outcomes. Until recently, there was a paucity of results regarding the effect of maternal and neonatal VDBP polymorphisms on vitamin D status during pregnancy in the Mediterranean region, with a high prevalence of hypovitaminosis D. We aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphisms and different maternal and neonatal 25-hydroxyvitamin D (25(OH)D) cut-offs on maternal and neonatal vitamin D profile. Blood samples were obtained from a cohort of 66 mother–child pairs at birth. Our results revealed that: (i) Maternal VDBP polymorphisms do not affect neonatal vitamin D status at birth, in any given internationally adopted maternal or neonatal cut-off for 25(OH)D concentrations; (ii) neonatal VDBP polymorphisms are not implicated in the regulation of neonatal vitamin D status at birth; (iii) comparing the distributions of maternal VDBP polymorphisms and maternal 25(OH)D concentrations, with cut-offs at birth, revealed that mothers with a CC genotype for rs2298850 and a CC genotype for rs4588 tended to demonstrate higher 25(OH)D (≥75 nmol/L) during delivery (p = 0.05 and p = 0.04, respectively), after adjustments for biofactors that affect vitamin D equilibrium, including UVB, BMI and weeks of gestation. In conclusion, this study from Southern Europe indicates that maternal and neonatal VDBP polymorphisms do not affect neonatal vitamin D status at birth, whereas mothers with CC genotype for rs2298850 and CC genotype for rs4588 demonstrate higher 25(OH)D concentrations. Future larger studies are required to establish a causative effect of these specific polymorphisms in the attainment of an adequate (≥75 nmol/L) maternal vitamin D status during pregnancy.


Ella Rhoads Higginson (b. 1862?–d. 1940) was born in Council Grove, Kansas, a launching point for westward movement of settler colonialists. When she was a child, her family moved to Oregon, traveling in a wagon train following the old Oregon Trail. The family eventually settled in Oregon City, where she was educated in private school. Ella’s strong interests in reading and writing began early. Her parents possessed a substantial library that included books by Irving, Longfellow, Shakespeare, and Tennyson. Ella began writing when she was eight. Her first publication, the poem “Dreams of the Past,” appeared in The Oregon City newspaper when she was fourteen. The following year she began work on The Oregon City Enterprise newspaper, learning typesetting and editorial writing. She also started publishing fiction. In 1885, she married Russell Carden Higginson, a businessman who was a cousin to New England author Thomas Wentworth Higginson. The couple moved north to Whatcom (later Bellingham), Washington, where Higginson lived for fifty-two years until her death. There she devoted herself to writing. She soon became the first influential Pacific Northwest author. People around the world were introduced to the region when they read Higginson’s award-winning writing. Her descriptions of majestic mountains, vast forests, and the scenic waters of the Puget Sound presented the then-remote, unfamiliar Pacific Northwest to eager readers. Her characterizations of white women and men who inhabited the region revealed what life was like in this part of the nation as opposed to regions such as New England. Higginson’s celebrated writings were the first to place the Pacific Northwest on the literary map. Her talent was widely recognized. The prestigious Macmillan Company, which became her publisher, approached her seeking to print her work. She was awarded prizes from magazines such as Collier’s and McClure’s. Her poems were set to music and performed internationally. She published over eight hundred works in her lifetime. However, World War I altered the means of production, resulting in books going out of print and diminishing reputations of well-known authors, especially writers of color and women. Most of Higginson’s books went out of print. After the war, new editors, mostly white men, managed US newspapers, periodicals, and publishing companies. Largely uninterested in prewar authors, they sought writing from nascent literary movements such as Modernism while also promoting works by overlooked white male authors such as Melville. Higginson’s reputation faded in the last decades of her life. By the time she was chosen first Poet Laureate of Washington State in 1931, she and her work were largely remembered only in the Pacific Northwest. When she died in 1940, she was almost completely forgotten. In the 21st century, Higginson and her writings are returning to literary distinction.


2012 ◽  
Vol 16 (6) ◽  
pp. 945-951 ◽  
Author(s):  
Emilio González-Parra ◽  
Pablo Justo Avila ◽  
Ignacio Mahillo-Fernández ◽  
Carolina Lentisco ◽  
Carolina Gracia ◽  
...  

2009 ◽  
Vol 201 (6) ◽  
pp. S165
Author(s):  
Devon Ramaeker ◽  
Hyagriv Simhan ◽  
Lisa Bodnar ◽  
Katherine Himes

2015 ◽  
Vol 30 (2) ◽  
pp. 124-133 ◽  
Author(s):  
Yan Tian ◽  
Claudia Holzman ◽  
Anna M. Siega-Riz ◽  
Michelle A. Williams ◽  
Nancy Dole ◽  
...  

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