Use of a Human Tissue-Engineered Oral Mucosa in Clinical Trials

2007 ◽  
Vol 65 (9) ◽  
pp. 8
Author(s):  
Michiko Yoshizawa
Keyword(s):  
Clinical Trials ◽  
Oral Mucosa ◽  
Human Tissue

scholarly journals Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

2020 ◽  
Vol 21 (21) ◽  
pp. 8390
Author(s):  
Antonio Martinez-Lopez ◽  
Trinidad Montero-Vilchez ◽  
Álvaro Sierra-Sánchez ◽  
Alejandro Molina-Leyva ◽  
Salvador Arias-Santiago
Keyword(s):  
Tissue Engineering ◽  
Clinical Trials ◽  
Alopecia Areata ◽  
Human Tissue ◽  
Basic Research ◽  
Androgenic Alopecia ◽  
Medical Products ◽  
Scarring Alopecia ◽  
Medical Therapies ◽  
Surgical Treatments

Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.

Neural Tissue Xenotransplantation: What is Needed Prior to Clinical Trials in Parkinson's Disease?

2000 ◽  
Vol 9 (2) ◽  
pp. 235-246 ◽  
Author(s):  
Roger A. Barker ◽  
A. Lisa Kendall ◽  
Håkan Widner ◽  
H. Widner ◽  
L. Larsson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Human Tissue ◽  
Neural Tissue ◽  
Fetal Tissue ◽  
Suitable Material ◽  
Human Fetal Tissue ◽  
Critical Issues ◽  
Alternative Sources

Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the development of our clinical xenotransplantation research programs. We advocate that these, or similar, criteria should be adopted and made explicit by other centers contemplating similar clinical trials.

Raman fiberoptic probe for monitoring human tissue engineered oral mucosa constructs

2013 ◽  
Author(s):  
Alexander Khmaladze ◽  
Shiuhyang Kuo ◽  
Paul Okagbare ◽  
Cynthia L. Marcelo ◽  
Stephen E. Feinberg ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Human Tissue ◽  
Fiberoptic Probe

Ethical reflections on clinical trials with human tissue engineered products

2008 ◽  
Vol 34 (9) ◽  
pp. e1-e1 ◽  
Author(s):  
L Trommelmans ◽  
J Selling ◽  
K Dierickx
Keyword(s):  
Clinical Trials ◽  
Human Tissue ◽  
Ethical Reflections

scholarly journals N-acetyl cysteine prevents pain and hypersensitivity of bleaching agents without affecting their aesthetic appeal; evidence from in vitro to animal studies and to human clinical trials

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Diana Wang ◽  
Kawaljit Kaur ◽  
Avina Paranjpe ◽  
Eric Lee ◽  
Matthew Wasilewski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Side Effects ◽  
Oral Mucosa ◽  
Animal Studies ◽  
In Vitro Assays ◽  
Electron Microscopic ◽  
Adverse Side Effects ◽  
Acetyl Cysteine

Abstract Background Tooth hypersensitivity and pain are undesirable side effects of bleaching agents in humans. The aim of this study is to implement strategies to counter such side effects, and to demonstrate the efficacy and mechanisms of action of N-acetyl cysteine (NAC) in countering the side effects of clinically used bleaching agents. Methods In a series of in vitro experiments, animal model studies, and human clinical trials, we demonstrate that NAC protects oral mucosa and teeth from damage induced by bleaching agents. Results The addition of NAC along with clinically used bleaching agents to dental pulp stromal/stem cells (DPSCs), stem-cells of apical papillae (SCAP) and oral epithelial cells, inhibited cell death mediated by bleaching agents in several in vitro assays. In addition, rat teeth, when treated with chair-side or over-the-counter bleaching agents, exerted adverse side effects to pulpal and gingival tissues as evidenced by the white lesions of gingivae as well as decreased survival and function of DPSCs. These side effects of bleaching agents were greatly mitigated by the application of NAC to the surfaces of the teeth and to the oral mucosa. NAC protected the surface topography and the appearance of the tissues after bleaching using scanning electron microscopic (SEM) analysis. Finally, application of NAC prior to the bleaching demonstrated significant translational benefit for the patients since it ameliorated pain and hypersensitivity and protected gingivae from bleaching induced white lesions and improved inflammatory index in the oral mucosa in human clinical trials. Conclusions Therefore, application of NAC to the surfaces of the teeth and oral mucosa prior to the use of bleaching materials is beneficial for countering adverse side effects of bleaching in patients and decreases pain, sensitivity, and potential damage to the dentition and oral mucosa associated with bleaching. Trial registration NCT03534115 (NAC Prevents Side-Effects of Teeth Bleaching). Registration 4 December 2014.

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