Nasal cavity shape in unilateral choanal atresia and the role of fetal ventilation in facial growth

Bilateral choanal atresia (CA) is a rare congenital malformation frequently associated with other anomalies. CHARGE association is closely linked to bilateral CA. The aim of this study was to describe the outcomes of the endoscopic repair in bilateral CA, and to assess the role of postoperative nasal stenting in two cohorts of CHARGE-associated and non-syndromic CA. Thirty-nine children were retrospectively analyzed (16 patients had CHARGE-associated CA). The rate of postoperative neochoanal restenosis was 31.3% in the CHARGE population, and 47.8% in the non-syndromic CA cohort. Data on postoperative synechiae and granulation tissue formation, need for endonasal toilette and dilation procedures, and number of procedures per patient were presented. Stent positioning led to a higher number of postoperative dilation procedures per patient in the non-syndromic cohort (p = 0.018), and to a higher rate of restenosis both in the CHARGE-associated, and non-syndromic CA populations. Children with CHARGE-associated and non-syndromic bilateral CA benefitted from endonasal endoscopic CA correction. The postoperative application of an endonasal stent should be carefully evaluated.

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The Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Development

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0040-1715593 ◽

2020 ◽

Author(s):

Nuray Bayar Muluk ◽

Osman Kürşat Arikan ◽

Pınar Atasoy ◽

Rahmi Kiliç ◽

Eda Tuna Yalçinozan

Keyword(s):

Nasal Cavity ◽

Nasal Polyp ◽

Nasal Polyps ◽

Deep Layer ◽

Ethmoid Sinus ◽

Adult Patients ◽

Control Group ◽

Study Group ◽

Deep Layers

Abstract Objectives The aim of this study was to investigate the role of CD68 (+) histiocytic macrophages (H-M) in the nasal polyp pathogenesis. Materials and Methods The study group consisted of 24 adult patients with nasal polyposis. The control group consisted of 11 adult patients without nasal polyps. A total of 36 nasal polyp samples (10-nasal cavity, 10-maxillary sinus, and 16-ethmoid sinus) from the study group and 11 inferior turbinate samples from the control group were analyzed by immunohistochemical staining, with monoclonal antibodies against CD68 (+) H-M. Results CD68 positivity was significantly higher than the control group in the subepithelial (SE) layer of the ethmoid sinus, and deep layers of nasal cavity, maxillary, and ethmoid sinuses. In SE and deep layers of ethmoid and maxillary sinuses, CD68 positivity was significantly higher than that of the epithelial layer. In the deep layer, histiocytic macrophages tended to gather around eosinophils. Conclusion The high numbers of CD68 (+) histiocytic macrophages mainly located in deep layer of lamina propria may be responsible for the phagocytosis of eosinophils within the polyp tissue. Therefore, it may be concluded that increased macrophages in nasal polyps do not trigger the growth of nasal polyps. Instead, they may serve to reduce the number of eosinophils in already-developed nasal polyps.

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The role of cavity shape on spatially confined laser-induced breakdown spectroscopy

Physics of Plasmas ◽

10.1063/1.5039787 ◽

2018 ◽

Vol 25 (7) ◽

pp. 073301 ◽

Cited By ~ 11

Author(s):

Qiuyun Wang ◽

Anmin Chen ◽

Dan Zhang ◽

Ying Wang ◽

Laizhi Sui ◽

...

Keyword(s):

Laser Induced Breakdown Spectroscopy ◽

Cavity Shape ◽

Breakdown Spectroscopy ◽

Laser Induced Breakdown

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The primary role of functional matrices in facial growth

American Journal of Orthodontics ◽

10.1016/0002-9416(69)90034-7 ◽

1969 ◽

Vol 55 (6) ◽

pp. 566-577 ◽

Cited By ~ 435

Author(s):

Melvin L. Moss ◽

Letty Salentijn

Keyword(s):

Primary Role ◽

Facial Growth

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The Role of Intensity Modulated Radiation Therapy for Favorable Stage Tumor of the Nasal Cavity or Ethmoid Sinus

American Journal of Clinical Oncology ◽

10.1097/01.coc.0000182600.51019.de ◽

2005 ◽

Vol 28 (5) ◽

pp. 474-478 ◽

Cited By ~ 18

Author(s):

Heather D. Pacholke ◽

Robert J. Amdur ◽

Debbie A. Louis ◽

Huey Yang ◽

William M. Mendenhall

Keyword(s):

Radiation Therapy ◽

Nasal Cavity ◽

Intensity Modulated Radiation Therapy ◽

Ethmoid Sinus ◽

Intensity Modulated

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The Role of Retinoids in Normal and Abnormal Embryonic Craniofacial Morphogenesis

Critical Reviews in Oral Biology & Medicine ◽

10.1177/10454411920040010701 ◽

1992 ◽

Vol 4 (1) ◽

pp. 93-109 ◽

Cited By ~ 14

Author(s):

Joy M. Richman

Keyword(s):

Craniofacial Development ◽

Facial Growth ◽

Specific Effects ◽

The Face ◽

Facial Development ◽

Lines Of Evidence ◽

Craniofacial Morphogenesis

The objective of this article is to evaluate the role of retinoids in the developing head and face. This article covers two lines of evidence that strongly support a role for retinoids in craniofacial development. First, the specific effects of exogenous retinoids on the head and face are covered and mechanisms for the specificity discussed. Second, the function of endogenous retinoids in facial development is discussed in relation to the distribution of retinoid-binding substances in the face. Finally, the interaction of retinoids with other genes known to be expressed in the face as well as other factors required for facial growth is discussed.

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Choanal Atresia- A Clinical Study and Review of Literature

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703555 ◽

2012 ◽

Vol 02 (01) ◽

pp. 37-41

Author(s):

Satheesh Kumar Bhandary ◽

Vadisha Bhat ◽

Shwetha Shenoy M.

Keyword(s):

Nasal Cavity ◽

Choanal Atresia ◽

Invasive Procedure ◽

Definitive Treatment ◽

Minimally Invasive Procedure ◽

Review Of Literature ◽

Severe Respiratory Distress ◽

Oropharyngeal Airway ◽

Transpalatal Approach ◽

Alar Rim

AbstractChoanal atresia is a developmental anomaly where there is failure of communication of the nasal cavity to the nasopharynx. The atresia can be membranous or bony in nature, but may be mixed as is seen in most of the cases. Bilateral choanal atresia is an emergency condition and newborns can have severe respiratory distress and cyanosis at birth. Failure to pass an 8 F catherter through the nasal cavity more than 5.5 cm from the alar rim points to the presence of choanal atresia. In emergency, bilateral choanal atresia is managed with an oropharyngeal airway. Flexible nasal endoscopy and CT scan can confirm the diagnosis of choanal atresia. Surgery is the definitive treatment which can be done either by transnasal or transpalatal approach. The transnasal endoscopic route is currently the preferred procedure and can be performed as a minimally invasive procedure. This has less complications and a high success rate. We studied four cases of unilateral choanal atresia presented to our hospital, with respect to the etiological factors, clinical features and management.

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Congenital Bony Nasal Cavity Deformities

American Journal of Rhinology ◽

10.2500/105065898781390280 ◽

1998 ◽

Vol 12 (2) ◽

pp. 81-86 ◽

Cited By ~ 12

Author(s):

Jacqueline E. Jones ◽

Eytan Young ◽

Linda Heier

Keyword(s):

Soft Tissue ◽

Respiratory Distress ◽

Airway Obstruction ◽

Nasal Cavity ◽

Congenital Anomalies ◽

Clinical Management ◽

Choanal Atresia ◽

Anatomical Features ◽

Tissue Edema ◽

Pyriform Aperture

Although the most common form of nasal obstruction in neonates is soft tissue edema, congenital bony nasal deformities are being recognized as an important cause of newborn airway obstruction. In addition to the well described choanal atresia, CT imaging of the newborn in respiratory distress reveals two other forms of bony nasal cavity deformities: nasal pyriform aperture stenosis and nasal cavity stenosis. All of the three types of bony nasal cavity deformities have characteristic anatomical features, are associated with distinctive congenital anomalies, and are postulated to have differing embryological causes. Five patients with congenital bony nasal cavity deformities are presented. These cases illustrate the clinical and radiological presentation of varied types of congenital nasal cavity obstruction as well as the criteria used to guide clinical management.

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