Evaluation of volatile ion-pair reagents for the liquid chromatography–mass spectrometry analysis of polar compounds and its application to the determination of methadone in human plasma

2006 ◽  
Vol 40 (3) ◽  
pp. 679-688 ◽  
Author(s):  
Songmei Gao ◽  
Siddhartha Bhoopathy ◽  
Zong-Ping Zhang ◽  
D. Scott Wright ◽  
Rand Jenkins ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Plasma ◽  
Polar Compounds ◽  
Ion Pair ◽  
Mass Spectrometry Analysis ◽  
Liquid Chromatography Mass Spectrometry ◽  
Spectrometry Analysis ◽  
Chromatography Mass Spectrometry

scholarly journals Sample Preparation and Liquid Chromatography Mass Spectrometry Analysis of Alkylphenolic Compounds and Steroid Sex Hormones in Sediments

2002 ◽  
Vol 2 ◽  
pp. 1610-1616 ◽  
Author(s):  
Mira Petrovia ◽  
Damia Barcela
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Sex Hormones ◽  
Degradation Products ◽  
Mass Spectrometry Analysis ◽  
Liquid Chromatography Mass Spectrometry ◽  
Spectrometry Analysis ◽  
Chromatography Mass Spectrometry ◽  
Steroid Sex Hormones

A new methodology, based on the use of accelerated solvent extraction (ASE) and highly selective cleanup using restricted access material (RAM) on-line coupled with liquid chromatography–mass spectrometry (LC–MS), is presented for the simultaneous and unequivocal determination of alkylphenol ethoxylates (APEOs), their degradation products and halogenated derivatives, and steroid sex hormones in sediment samples. Using the integrated RAM–LC–MS system, the simultaneous determination of alkylphenolic compounds and sex hormones was achieved, yielding recoveries higher than 60% and producing low MS background noise.

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