Development and implementation of a pass/fail field-friendly method for detecting sildenafil in suspect pharmaceutical tablets using a handheld Raman spectrometer and silver colloids

We developed and optimized surface-enhanced Raman spectrometry (SERS) methods for trace analysis of explosive vapour and particles using a hand-held Raman spectrometer in the field.

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UV/Vis absorption spectroelectrochemistry of folic acid

Journal of Solid State Electrochemistry ◽

10.1007/s10008-021-05026-5 ◽

2021 ◽

Author(s):

F. Olmo ◽

A. Rodriguez ◽

A. Colina ◽

A. Heras

Keyword(s):

Folic Acid ◽

Optical Signal ◽

Oxidation Products ◽

Basic Medium ◽

Analytical Technique ◽

Pharmaceutical Tablets ◽

Solution Interface ◽

Vitamin B9 ◽

Analytical Protocol ◽

Parallel Configuration

AbstractUV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.

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Sampling unit for efficient signal detection and application to liquid chromatography-Raman spectroscopy

New Journal of Chemistry ◽

10.1039/d0nj06054b ◽

2021 ◽

Author(s):

Yu-Hao Lo ◽

Shu-Chi Li ◽

Hirotsugu Hiramatsu

Keyword(s):

Raman Spectroscopy ◽

Liquid Chromatography ◽

Signal Detection ◽

Signal Intensity ◽

Sampling Unit ◽

Raman Spectrometer ◽

Unit Design

A new sampling unit design enhances the signal intensity and is available to combine Raman spectrometer with liquid chromatography.

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Determination of drug, excipients and coating distribution in pharmaceutical tablets using NIR-CI

Journal of Pharmaceutical Analysis ◽

10.1016/j.jpha.2011.11.003 ◽

2012 ◽

Vol 2 (2) ◽

pp. 90-97 ◽

Cited By ~ 36

Author(s):

Anna Palou ◽

Jordi Cruz ◽

Marcelo Blanco ◽

Jaume Tomàs ◽

Joaquín de los Ríos ◽

...

Keyword(s):

Pharmaceutical Tablets

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Photochemical stability of warfarin potassium in powdered pharmaceutical tablets

Bio-Medical Materials and Engineering ◽

10.3233/bme-201167 ◽

2021 ◽

Vol 32 (2) ◽

pp. 115-129

Author(s):

Emi Horiguchi-Babamoto ◽

Makoto Otsuka

Keyword(s):

High Performance ◽

Partial Least Squares Regression ◽

Pediatric Patients ◽

Reversed Phase ◽

Least Squares Regression ◽

Brand Name ◽

Pharmaceutical Tablets ◽

Light Stability ◽

Warfarin Potassium ◽

The Stability

BACKGROUND: Warfarin potassium (Wf) commercial tablets originally formulated for adults are ground before administration to pediatric patients and elderly patients with dysphagia. OBJECTIVE: The present study investigated the effect of tablet grinding on the photostability of four types of commercial Wf tablets and predicted the photostability of the tablet powders by chemometric analysis. METHODS: The photodegradation of Wf content was evaluated by reversed-phase column high-performance liquid chromatography with ultraviolet (HPLC-UV). RESULTS: The bulk Wf powder was relatively photostable, whereas ground Wf tablets underwent substantial photodegradation. The photostability of the ground powders of a brand-name Wf commercial tablet and three generic Wf commercial tablets was quantitatively assessed and compared. In certain cases, the Wf in all the three ground generic tablets was less photostable than in the ground brand-name tablets. After 28 days of light irradiation, the Wf content decreased to 69.79% in the brand-name tablets, while it was 31.90% in some generic tablets. To clarify the factors influencing the relative photostability in various Wf formulations, we analyzed the intermolecular interactions between the active ingredient and the excipients by partial least-squares regression analysis based on photostability screening for each additive. CONCLUSION: The results suggested that the additives light anhydrous silicic acid and povidone adversely affect the stability of Wf tablets. In addition, the light stability of ground tablets was affected considerably by their formulation.

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