Lung Volume and Ventilation Inhomogeneity in Preterm Infants at 15-18 Months Corrected Age

2010 ◽  
Vol 156 (4) ◽  
pp. 542-549.e2 ◽  
Author(s):  
Sven M. Schulzke ◽  
Graham L. Hall ◽  
Elizabeth A. Nathan ◽  
Karen Simmer ◽  
Gary Nolan ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Lung Volume ◽  
Ventilation Inhomogeneity

scholarly journals Regional ventilation characteristics during non-invasive respiratory support in preterm infants

2020 ◽  
pp. fetalneonatal-2020-320449
Author(s):  
Jessica Thomson ◽  
Christoph M Rüegger ◽  
Elizabeth J Perkins ◽  
Prue M Pereira-Fantini ◽  
Olivia Farrell ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Repeated Measure ◽  
Regional Ventilation ◽  
Quiet Breathing ◽  
Impedance Tomography ◽  
Non Invasive ◽  
Ventilation Inhomogeneity ◽  
The Right

ObjectivesTo determine the regional ventilation characteristics during non-invasive ventilation (NIV) in stable preterm infants. The secondary aim was to explore the relationship between indicators of ventilation homogeneity and other clinical measures of respiratory status.DesignProspective observational study.SettingTwo tertiary neonatal intensive care units.PatientsForty stable preterm infants born <30 weeks of gestation receiving either continuous positive airway pressure (n=32) or high-flow nasal cannulae (n=8) at least 24 hours after extubation at time of study.InterventionsContinuous electrical impedance tomography imaging of regional ventilation during 60 min of quiet breathing on clinician-determined non-invasive settings.Main outcome measuresGravity-dependent and right–left centre of ventilation (CoV), percentage of whole lung tidal volume (VT) by lung region and percentage of lung unventilated were determined for 120 artefact-free breaths/infant (4770 breaths included). Oxygen saturation, heart and respiratory rates were also measured.ResultsVentilation was greater in the right lung (mean 69.1 (SD 14.9)%) total VT and the gravity-non-dependent (ND) lung; ideal–actual CoV 1.4 (4.5)%. The central third of the lung received the most VT, followed by the non-dependent and dependent regions (p<0.0001 repeated-measure analysis of variance). Ventilation inhomogeneity was associated with worse peripheral capillary oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) (p=0.031, r2 0.12; linear regression). In those infants that later developed bronchopulmonary dysplasia (n=25), SpO2/FiO2 was worse and non-dependent ventilation inhomogeneity was greater than in those that did not (both p<0.05, t-test Welch correction).ConclusionsThere is high breath-by-breath variability in regional ventilation patterns during NIV in preterm infants. Ventilation favoured the ND lung, with ventilation inhomogeneity associated with worse oxygenation.

Effect of Minimally Invasive Surfactant Therapy on Lung Volume and Ventilation in Preterm Infants

2016 ◽  
Vol 170 ◽  
pp. 67-72 ◽  
Author(s):  
Pauline S. van der Burg ◽  
Frans H. de Jongh ◽  
Martijn Miedema ◽  
Inez Frerichs ◽  
Anton H. van Kaam
Keyword(s):  
Minimally Invasive ◽  
Preterm Infants ◽  
Lung Volume ◽  
Surfactant Therapy

scholarly journals Decline in Lung Volume With Duchenne Muscular Dystrophy Is Associated With Ventilation Inhomogeneity

2015 ◽  
Vol 60 (9) ◽  
pp. 1257-1263 ◽  
Author(s):  
F. Stehling ◽  
C. Dohna-Schwake ◽  
U. Mellies ◽  
J. Grosse-Onnebrink
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Lung Volume ◽  
Ventilation Inhomogeneity

scholarly journals Chest x-ray findings versus lung volume as measured by the SF6 washout technique in ventilated preterm infants. † 1606

1997 ◽  
Vol 41 ◽  
pp. 270-270
Author(s):  
Ulrich Thome ◽  
Andreas Töpfer ◽  
Peter Schaller ◽  
Frank Pohlandt
Keyword(s):  
Preterm Infants ◽  
Lung Volume ◽  
X Ray ◽  
Chest X Ray

Analysis of forced expiratory maneuvers from raised lung volumes in preterm infants

1998 ◽  
Vol 85 (5) ◽  
pp. 1989-1997 ◽  
Author(s):  
Matthias Henschen ◽  
Janet Stocks ◽  
Ah-Fong Hoo ◽  
Paul Dixon
Keyword(s):  
Preterm Infants ◽  
Lung Volume ◽  
Elastic Equilibrium ◽  
Forced Expiration ◽  
Compression Technique ◽  
Lung Volumes ◽  
Conventional Analysis ◽  
Airway Function ◽  
Fixed Times ◽  
Made In

During recent years it has been suggested that forced expiratory measurements, derived from a lung volume set by a standardized inflation pressure, are more reproducible than those attained during tidal breathing when the rapid thoracoabdominal compression technique is used in infants. The aim of this study was to evaluate the feasibility of obtaining measurements from raised lung volumes in unsedated preterm infants. Measurements were made in 18 infants (gestational age 26–35 wk, postnatal age 1–10 wk, test weight 1.4–3.5 kg). Several inflations [1.5–2.5 kPa (15–25 cmH2O)] were used to briefly inhibit respiratory effort before the rapid thoracoabdominal compression was performed. Conventional analysis of flows and volumes at fixed times and percentages of the forced expiration resulted in a relatively high variability in this population. However, by using the elastic equilibrium point (i.e., the passively determined lung volume, derived from passive expirations before the forced expiration) as a volume landmark, it was feasible to achieve reproducible results in unsedated preterm infants, despite their strong respiratory reflexes and rapid respiratory rates. Because this approach is independent of changes in expiratory time, expired volume, or applied pressures, it may facilitate investigation of the effects of growth, development, and disease on airway function in infants, particularly during the first weeks of life, when conventional analysis of forced expirations may be inappropriate.

Effect of ventilation inhomogeneity on "intrabreath" measurements of diffusing capacity in normal subjects

1993 ◽  
Vol 75 (2) ◽  
pp. 927-932 ◽  
Author(s):  
D. J. Cotton ◽  
M. B. Prabhu ◽  
J. T. Mink ◽  
B. L. Graham
Keyword(s):  
Lung Volume ◽  
Hold Time ◽  
Normal Subjects ◽  
Phase Iii ◽  
Breath Hold ◽  
Diffusing Capacity ◽  
Ventilation Inhomogeneity ◽  
Single Breath ◽  
The Mean ◽  
And Diffusion

In normal seated subjects we increased single-breath ventilation inhomogeneity by changing both the preinspiratory lung volume and breath-hold time and examined the ensuing effects on two different techniques of measuring the diffusing capacity of the lung for carbon monoxide (DLCO). We measured the mean single-breath DLCO using the three-equation method (DLCOSB-3EQ) and also measured DLCO over discrete intervals during exhalation by the "intrabreath" method (DLCOexhaled). We assessed the distribution of ventilation using the normalized phase III slope for helium (SN). DLCOSB-3EQ was unaffected by preinspiratory lung volume and breath-hold time. DLCOexhaled increased with increasing preinspiratory lung volume and decreased with increasing breath-hold time. These changes correlated with the simultaneously observed changes in ventilation inhomogeneity as measured by SN (P < 0.01). We conclude that measurements of DLCOexhaled do not accurately reflect the mean DLCO. Intrabreath methods of measuring DLCO are based on the slope of the exhaled CO concentration curve, which is affected by both ventilation and diffusion inhomogeneities. Although DLCOexhaled may theoretically provide information about the distribution of CO uptake, the concomitant effects of ventilation nonuniformity on DLCOexhaled may mimic or mask the effects of diffusion nonuniformity.

Effect of Nasal Continuous and Biphasic Positive Airway Pressure on Lung Volume in Preterm Infants

2013 ◽  
Vol 162 (4) ◽  
pp. 691-697 ◽  
Author(s):  
Martijn Miedema ◽  
Pauline S. van der Burg ◽  
Sabine Beuger ◽  
Frans H. de Jongh ◽  
Inez Frerichs ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Lung Volume ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Biphasic Positive Airway Pressure

Effects of ventilation inhomogeneity on DLcoSB-3EQ in normal subjects

1992 ◽  
Vol 73 (6) ◽  
pp. 2623-2630 ◽  
Author(s):  
D. J. Cotton ◽  
M. B. Prabhu ◽  
J. T. Mink ◽  
B. L. Graham
Keyword(s):  
Lung Volume ◽  
Vital Capacity ◽  
Hold Time ◽  
Airflow Obstruction ◽  
Normal Subjects ◽  
Phase Iii ◽  
Mixing Efficiency ◽  
Breath Hold ◽  
Ventilation Inhomogeneity ◽  
Single Breath

In patients with airflow obstruction, we found that ventilation inhomogeneity during vital capacity single-breath maneuvers was associated with decreases in the three-equation single-breath CO diffusing capacity of the lung (DLcoSB-3EQ) when breath-hold time (tBH) decreased. We postulated that this was due to a significant resistance to diffusive gas mixing within the gas phase of the lung. In this study, we hypothesized that this phenomenon might also occur in normal subjects if the breathing cycle were altered from traditional vital capacity maneuvers to those that increase ventilation inhomogeneity. In 10 normal subjects, we examined the tBH dependence of both DLcoSB-3EQ and the distribution of ventilation, measured by the mixing efficiency and the normalized phase III slope for helium. Preinspiratory lung volume (V0) was increased by keeping the maximum end-inspiratory lung volume (Vmax) constant or by increasing V0 and Vmax. When V0 increased while Vmax was kept constant, we found that the tBH-independent and the tBH-dependent components of ventilation inhomogeneity increased, but DLcoSB-3EQ was independent of V0 and tBH. Increasing V0 and Vmax did not change ventilation inhomogeneity at a tBH of 0 s, but the tBH-dependent component decreased. DLcoSB-3EQ, although independent of tBH, increased slightly with increases in Vmax. We conclude that in normal subjects increases in ventilation inhomogeneity with increases in V0 do not result in DLcoSB-3EQ becoming tBH dependent.

scholarly journals Lung volume reduction surgery in preterm infants with bronchopulmonary dysplasia. A case report

2013 ◽  
Vol 1 (2) ◽  
pp. 96-99 ◽  
Author(s):  
Jan Laffolie ◽  
Markus Hirschburger ◽  
Jürgen Bauer ◽  
Lars D. Berthold ◽  
Dirk Faas ◽  
...  
Keyword(s):  
Case Report ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Lung Volume ◽  
Volume Reduction ◽  
Lung Volume Reduction Surgery ◽  
Lung Volume Reduction
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