Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model

2012 ◽  
Vol 47 (6) ◽  
pp. 1135-1142 ◽  
Author(s):  
Rebecca M. Rentea ◽  
Jennifer L. Liedel ◽  
Scott R. Welak ◽  
Laura D. Cassidy ◽  
Alan N. Mayer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Barrier Function ◽  
Intestinal Alkaline Phosphatase ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Neonatal Necrotizing Enterocolitis

Deficiency of intestinal alkaline phosphatase in newborns predisposes to necrotizing enterocolitis in a neonatal rat model

2011 ◽  
Vol 213 (3) ◽  
pp. S85
Author(s):  
Rebecca M. Rentea ◽  
Jill S. Whitehouse ◽  
Jennifer L. Liedel ◽  
Kirkwood A. Pritchard ◽  
Alan N. Mayer ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Intestinal Alkaline Phosphatase ◽  
Neonatal Rat Model

Recombinant Human Erythropoietin Improves Gut Barrier Function in a Hemorrhagic Shock and Resuscitation Rat Model

2011 ◽  
Vol 71 ◽  
pp. S456-S461 ◽  
Author(s):  
Capt(N) Raymond L. C. Kao ◽  
Anargyros Xenocostas ◽  
David K. Driman ◽  
Tao Rui ◽  
Weixiong Huang ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Rat Model ◽  
Barrier Function ◽  
Recombinant Human Erythropoietin ◽  
Gut Barrier ◽  
Human Erythropoietin ◽  
Gut Barrier Function

Factors Known to Influence the Development of Necrotizing Enterocolitis to Modify Expression and Activity of Intestinal Alkaline Phosphatase in a Newborn Neonatal Rat Model

2018 ◽  
Vol 29 (03) ◽  
pp. 290-297 ◽  
Author(s):  
Rebecca Rentea ◽  
Matthea Rentea ◽  
Ben Biesterveld ◽  
Jennifer Liedel ◽  
David Gourlay
Keyword(s):  
Alkaline Phosphatase ◽  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Therapeutic Benefit ◽  
Formula Feeding ◽  
Neonatal Rat ◽  
Sprague Dawley ◽  
Intestinal Alkaline Phosphatase ◽  
Neonatal Rat Model ◽  
Expression And Activity

Introduction Prematurity, formula feeding, and early weaning strongly influence enterocyte differentiation. Intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, is one enzyme that is affected by these factors. IAP supplementation decreases the severity of necrotizing enterocolitis (NEC) injury. We, therefore, hypothesized that prematurity predisposes this population to NEC due to IAP deficiency and investigated IAP expression and function in a neonatal rat model. Materials and Methods Pre- and full-term newborn Sprague-Dawley rat pups were sacrificed on consecutive days of life both after vaginal or cesarean birth and following either breast or formula feeding. Results Compared with controls, cesarean delivery and formula feeding are associated with lower levels of IAP. The formula-fed pups continued to have low baseline IAP activity. Neither prematurity nor formula feeding led to differences of intestinal injury. Conclusion Prematurity and formula feeding are associated with inhibition of IAP expression and activity. Both may increase the risk of NEC and early enteral supplementation of IAP to newborns at risk of NEC may be of therapeutic benefit.

scholarly journals Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis

2017 ◽  
Vol 214 ◽  
pp. 278-285 ◽  
Author(s):  
Christopher J. McCulloh ◽  
Jacob K. Olson ◽  
Yijie Wang ◽  
Jennifer Vu ◽  
Sarah Gartner ◽  
...  
Keyword(s):  
Stem Cells ◽  
Necrotizing Enterocolitis ◽  
Barrier Function ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Different Types

scholarly journals Effect of Bile Pigments on the Compromised Gut Barrier Function in a Rat Model of Bile Duct Ligation

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98905 ◽  
Author(s):  
Kangkang Zhou ◽  
Mingshan Jiang ◽  
Yuanli Liu ◽  
Yilin Qu ◽  
Guojing Shi ◽  
...  
Keyword(s):  
Bile Duct ◽  
Rat Model ◽  
Barrier Function ◽  
Bile Duct Ligation ◽  
Bile Pigments ◽  
Gut Barrier ◽  
Gut Barrier Function ◽  
Duct Ligation
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