Defining the role of angioembolization in pediatric isolated blunt solid organ injury

Background: The present study of role of non-operative management in blunt abdominal trauma with solid organ injury was done to assess the feasibility and safety of non-operative management in hemodynamically stable patients and identify the causes, predictive factors to delineate the rate of non-operative management failure.Methods: A longitudinal observational study was carried out from September 2013 to November 2015. All cases of blunt trauma abdomen with ultrasonological e/o solid organ injury and were hemodynamically stable were included in study.Results: Total 138 cases presented with a history of blunt trauma abdomen of which 56 cases had ultrasonological evidence of solid organ injury. 8 cases were excluded as 6 of these were hemodynamically unstable at presentation while 1 had bowel perforation and another had severe head injury all requiring operative management. Maximum cases were of age group 21-30 years (41.66%) and 31-40 years (31.25%). 42 (87.5%) cases were male and 6 (12.5%) cases of 48 were females. 28 (66.67%) cases presented as Road Traffic Accident. 28 (66.67%) cases had abdominal pain as the commonest symptom while tenderness in 38 (79.17%) cases and tachycardia in 30 (75%) cases was the predominant sign. Most injuries were seen in spleen 23 (47.92%) cases f/b Liver with 14 (29.12%). Conservative management was successful in 40 (83.33%) cases and failed in 8 (16.67%) cases. Mortality of the study was 1 (2.08%) case.Conclusions: Non-operative strategy is a successful approach in patients who are hemodynamically stable and authors strongly recommend it.

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ROLE OF FOCUSED ABDOMINAL SONOGRAPHY FOR TRAUMA IN SOLID ORGAN INJURY IN PAEDIATRIC BLUNT ABDOMINAL TRAUMA

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2018/465 ◽

2018 ◽

Vol 7 (17) ◽

pp. 2074-2077

Author(s):

Rejum Ronya ◽

Rajib Ray Baruah ◽

Nirmal Bhattacharyya ◽

Jayanta Kumar Goswami ◽

Manoj Saha ◽

...

Keyword(s):

Abdominal Trauma ◽

Blunt Abdominal Trauma ◽

Organ Injury ◽

Solid Organ ◽

Solid Organ Injury ◽

Abdominal Sonography

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Pediatric solid organ injury management: the role of initial hematocrit in lean times

Journal of Emergency and Critical Care Medicine ◽

10.21037/jeccm.2019.08.03 ◽

2019 ◽

Vol 3 ◽

pp. 39-39

Author(s):

Marianne Miller ◽

Christine Perlick

Keyword(s):

Organ Injury ◽

Solid Organ ◽

Solid Organ Injury ◽

Injury Management

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The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

Cell Death and Disease ◽

10.1038/s41419-021-04019-6 ◽

2021 ◽

Vol 12 (8) ◽

Author(s):

Li Ning ◽

Xiong Rui ◽

Wang Bo ◽

Geng Qing

Keyword(s):

Histone Deacetylase ◽

Chromatin Remodeling ◽

Current Knowledge ◽

Organ Injury ◽

Solid Organ ◽

Solid Organ Injury ◽

Histone Deacetylase 3 ◽

Physiological Conditions ◽

Inflammatory Conditions ◽

Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

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