Implementation of an evidence-based accelerated pathway: can hospital length of stay for children with blunt solid organ injury be safely decreased?

2021 ◽  
Author(s):  
Sarah C. Stokes ◽  
Erin G. Brown ◽  
Jordan E. Jackson ◽  
David E. Leshikar ◽  
Jacob T. Stephenson
Keyword(s):  
Length Of Stay ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Organ Injury ◽  
Evidence Based ◽  
Solid Organ ◽  
Solid Organ Injury

Reduction of Inpatient Hospital Length of Stay in Lumbar Fusion Patients With Implementation of an Evidence-Based Clinical Care Pathway

Spine ◽  
2017 ◽  
Vol 42 (3) ◽  
pp. 169-176 ◽  
Author(s):  
Alison Bradywood ◽  
Farrokh Farrokhi ◽  
Barbara Williams ◽  
Mark Kowalczyk ◽  
C. Craig Blackmore
Keyword(s):  
Length Of Stay ◽  
Care Pathway ◽  
Lumbar Fusion ◽  
Clinical Care ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Evidence Based ◽  
Inpatient Hospital ◽  
Clinical Care Pathway

A Disciplined Approach to Implementation of Evidence-Based Practices Decreases ICU and Hospital Length of Stay in Traumatically Injured Patients

2010 ◽  
Vol 163 (2) ◽  
pp. 327-330 ◽  
Author(s):  
Julie E. Johnson ◽  
Benjamin D. Mosher ◽  
Chet A. Morrison ◽  
Paul D. Schneider ◽  
Penny Stevens ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Evidence Based ◽  
Evidence Based Practices ◽  
Injured Patients

Reducing pediatric asthma hospital length of stay through evidence-based quality improvement and deployment of computerized provider order entry

2019 ◽  
Vol 57 (2) ◽  
pp. 123-135 ◽  
Author(s):  
George A. Gellert ◽  
Crystal M. Davenport ◽  
Charles G. Minard ◽  
Claudia Castano ◽  
Kylynn Bruner ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Length Of Stay ◽  
Pediatric Asthma ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Evidence Based ◽  
Order Entry ◽  
Computerized Provider Order Entry

A Disciplines Approach to Implementation of Evidence-Based Practices Decreases ICU and Hospital Length of Stay in Traumatically Injured Patients

2010 ◽  
Vol 158 (2) ◽  
pp. 414-415
Author(s):  
J. Johnson ◽  
B.D. Mosher ◽  
P.D. Schneider ◽  
C. Morrison ◽  
P. Stevens ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Evidence Based ◽  
Evidence Based Practices ◽  
Injured Patients

scholarly journals The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing
Keyword(s):  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Current Knowledge ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Histone Deacetylase 3 ◽  
Physiological Conditions ◽  
Inflammatory Conditions ◽  
Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

scholarly journals 182. Missed Opportunities to Discontinue Unnecessary Vancomycin During Pharmacist Therapeutic Monitoring

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S98-S98
Author(s):  
Corey J Medler ◽  
Mary Whitney ◽  
Juan Galvan-Cruz ◽  
Ron Kendall ◽  
Rachel Kenney ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Adverse Drug Events ◽  
Academic Medical Center ◽  
Total Duration ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Therapeutic Monitoring ◽  
Resistant Bacteria ◽  
Therapeutic Drug ◽  
Missed Opportunities

Abstract Background Unnecessary and prolonged IV vancomycin exposure increases risk of adverse drug events, notably nephrotoxicity, which may result in prolonged hospital length of stay. The purpose of this study is to identify areas of improvement in antimicrobial stewardship for vancomycin appropriateness by clinical pharmacists at the time of therapeutic drug monitoring (TDM). Methods Retrospective, observational cohort study at an academic medical center and a community hospital. Inclusion: patient over 18 years, received at least three days of IV vancomycin where the clinical pharmacy TDM service assessed for appropriate continuation for hospital admission between June 19, 2019 and June 30, 2019. Exclusion: vancomycin prophylaxis or administered by routes other than IV. Primary outcome was to determine the frequency and clinical components of inappropriate vancomycin continuation at the time of TDM. Inappropriate vancomycin continuation was defined as cultures positive for methicillin-susceptible Staphylococcus aureus (MRSA), vancomycin-resistant bacteria, and non-purulent skin and soft tissue infection (SSTI) in the absence of vasopressors. Data was reported using descriptive statistics and measures of central tendency. Results 167 patients met inclusion criteria with 38.3% from the ICU. SSTIs were most common indication 39 (23.4%) cases, followed by pneumonia and blood with 34 (20.4%) cases each. At time of vancomycin TDM assessment, vancomycin continuation was appropriate 59.3% of the time. Mean of 4.22 ± 2.69 days of appropriate vancomycin use, 2.18 ± 2.47 days of inappropriate use, and total duration 5.42 ± 2.94. 16.4% patients developed an AKI. Majority of missed opportunities were attributed to non-purulent SSTI (28.2%) and missed MRSA nares swabs in 21% pneumonia cases (table 1). Conclusion Vancomycin is used extensively for empiric treatment of presumed infections. Appropriate de-escalation of vancomycin therapy is important to decrease the incidence of adverse effects, decreasing hospital length of stay, and reduce development of resistance. According to the mean duration of inappropriate therapy, there are opportunities for pharmacy and antibiotic stewardship involvement at the time of TDM to optimize patient care (table 1). Missed opportunities for vancomycin de-escalation Disclosures All Authors: No reported disclosures

Sign in / Sign up

Export Citation Format

Share Document