scholarly journals The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing
Keyword(s):  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Current Knowledge ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Histone Deacetylase 3 ◽  
Physiological Conditions ◽  
Inflammatory Conditions ◽  
Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

Embolization versus Surgery for Stabilized Patients with Solid Organ Injury

2021 ◽  
Author(s):  
Makoto Aoki ◽  
Toshikazu Abe ◽  
Shuichi Hagiwara ◽  
Daizoh Saitoh ◽  
Kiyohiro Oshima
Keyword(s):  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury

Defining the role of angioembolization in pediatric isolated blunt solid organ injury

2020 ◽  
Vol 55 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Robert A. Swendiman ◽  
Matthew A. Goldshore ◽  
Stephen J. Fenton ◽  
Michael L. Nance
Keyword(s):  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury

scholarly journals Free abdominal fluid without obvious solid organ injury upon CT imaging: an actual problem or simply over-diagnosing?

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
Vanessa M Banz ◽  
Muhammad U Butt ◽  
Heinz Zimmermann ◽  
Victor Jeger ◽  
Aristomenis K Exadaktylos
Keyword(s):  
Ct Imaging ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Actual Problem

Serial Computed Tomographic Scans Document Healing of Solid Organ Injury in a Trauma Patient with Multiple Injuries

2006 ◽  
Vol 61 (3) ◽  
pp. 765
Author(s):  
Fulvio Tagliabue ◽  
Gianmaria Confalonieri ◽  
Antonio Romelli ◽  
Maria Emanuela Limonta ◽  
Sabina Terragni ◽  
...  
Keyword(s):  
Trauma Patient ◽  
Organ Injury ◽  
Multiple Injuries ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Computed Tomographic

Rib Fracture Patterns Predict Thoracic Chest Wall and Abdominal Solid Organ Injury

2010 ◽  
Vol 76 (8) ◽  
pp. 888-891 ◽  
Author(s):  
Ammar Al-Hassani ◽  
Husham Abdulrahman ◽  
Ibrahim Afifi ◽  
Ammar Almadani ◽  
Ahmed Al-Den ◽  
...  
Keyword(s):  
Chest Wall ◽  
Rib Fractures ◽  
Organ Injury ◽  
Trauma Patients ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
High Association ◽  
Multiple Rib Fractures ◽  
Scapular Fractures ◽  
Sternal Fractures

Blunt trauma patients with rib fractures were studied to determine whether the number of rib fractures or their patterns were more predictive of abdominal solid organ injury and/or other thoracic trauma. Rib fractures were characterized as upper zone (ribs 1 to 4), midzone (ribs 5 to 8), and lower zone (ribs 9 to 12). Findings of sternal and scapular fractures, pulmonary contusions, and solid organ injures (liver, spleen, kidney) were characterized by the total number and predominant zone of ribs fractured. There were 296 men and 14 women. There were 38 patients with scapular fracture and 19 patients with sternal fractures. There were 90 patients with 116 solid organ injuries: liver (n = 42), kidney (n = 27), and spleen (n = 47). Lower rib fractures, whether zone-limited or overlapping, were highly predictive of solid organ injury when compared with upper and midzones. Scapular and sternal fractures were more common with upper zone fractures and pulmonary contusions increased with the number of fractured ribs. Multiple rib fractures involving the lower ribs have a high association with solid organ injury, 51 per cent in this series. The increasing number of rib fractures enhanced the likelihood of other chest wall and pulmonary injuries but did not affect the incidence of solid organ injury.

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