scholarly journals Predicting relapse after alcohol use disorder treatment in a high-risk cohort: The roles of anhedonia and smoking

2020 ◽  
Vol 126 ◽  
pp. 1-7 ◽  
Author(s):  
Linh-Chi Nguyen ◽  
Timothy C. Durazzo ◽  
Candice L. Dwyer ◽  
Andrew A. Rauch ◽  
Keith Humphreys ◽  
...  
2022 ◽  
pp. 1-10
Author(s):  
Gianna Spitta ◽  
Tobias Gleich ◽  
Kristin Zacharias ◽  
Oisin Butler ◽  
Ralph Buchert ◽  
...  

<b><i>Introduction:</i></b> Reduced striatal dopamine D2/3 receptor availability in alcohol use disorder (AUD) has been demonstrated in recent clinical studies and meta-analyses. However, only a limited number of studies investigated extrastriatal D2/3 availability in AUD or in at-risk populations. In line with a dimensional understanding of addiction, extrastriatal dopaminergic neuroadaptations have been suggested to be relevant from a pathobiological perspective. <b><i>Methods:</i></b> We investigated D2/3 receptor availability via <sup>18</sup>F-fallypride positron emission tomography applying a region of interest (ROI) approach. We selected ROIs for the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC). Our sample included 19 healthy controls (low risk [LR]), 19 individuals at high risk (HR) to develop addiction, and 20 recently detoxified AUD patients. <b><i>Results:</i></b> We found significantly higher D2/3 receptor availability of HR compared to AUD in the left and right rostral ACC (rACC), as well as in the left ventrolateral PFC (vlPFC). We did not observe a significant difference between AUD and LR. After corrections for multiple comparisons none of the ROIs reached significance throughout the group comparison. The D2/3 receptor availability in the left rACC was inversely correlated with symptom severity assessed with the Alcohol Dependency Scale. <b><i>Discussion:</i></b> To our knowledge, the present work is the first study investigating extrastriatal D2/3 receptor availabilities in individuals at HR and patients with AUD. The observation that D2/3 receptor availabilities are highest in HR might suggest that their pathobiology differs from subjects with AUD. Future studies are necessary to clarify the intraindividual course of this biomarker over different disease stages and its possible role as a risk or protective factor.


2019 ◽  
Vol 43 (2) ◽  
pp. 334-341 ◽  
Author(s):  
Jessica L. Mellinger ◽  
Anne Fernandez ◽  
Kerby Shedden ◽  
G. Scott Winder ◽  
Robert J. Fontana ◽  
...  

2016 ◽  
Vol 29 (1) ◽  
pp. 37-49 ◽  
Author(s):  
L. Berger ◽  
M. Brondino ◽  
M. Fisher ◽  
R. Gwyther ◽  
J. C. Garbutt

2019 ◽  
pp. 088626051988386
Author(s):  
Kaitlin E. Bountress ◽  
Daniel Bustamante ◽  
Christina Sheerin ◽  
Danielle M. Dick ◽  
Ananda B. Amstadter ◽  
...  

College is a high-risk time for interpersonal trauma (IPT) exposure (e.g., physical or sexual abuse/assault), a potent form of trauma exposure. College is also a high-risk time for alcohol misuse, as use begins and increases in adolescence and peaks in the early/mid-20s. In addition, although IPT is associated with alcohol misuse, less clear is whether distal (prior to college) or proximal (during college) IPT impacts alcohol use disorder (AUD) symptoms at the beginning of college and/or changes in symptoms during college. Data were collected from a large, longitudinal study of college students, attending a large public university in the southeast, who had reported lifetime IPT as well as lifetime alcohol use. Participants in the current study were 18.5 years old ( SD = 0.46), primarily female (67.2%), and of diverse racial backgrounds (e.g., 53.4% White, 18.5% Black, 12.7% Asian, 15.4% Other). Latent change score analyses were employed to test the impact of IPT prior to college and IPT during college on initial levels of, and changes in, AUD symptoms during college. Those who experienced an IPT prior to college reported more AUD symptoms at the beginning of college and less changes in AUD symptoms during the first year of college. Those who experienced an IPT in the first 2 and last 2 years of college reported greater increases in symptoms in the first 2 and last 2 years of college, respectively. Findings suggest that prevention and intervention efforts for those who experience an IPT prior to or during college may be useful in reducing AUD symptoms during that time period.


2018 ◽  
Vol 91 ◽  
pp. 20-27 ◽  
Author(s):  
Jessica L. Mellinger ◽  
G. Scott Winder ◽  
Melissa DeJonckheere ◽  
Robert J. Fontana ◽  
Michael L. Volk ◽  
...  

2014 ◽  
Vol 38 (7) ◽  
pp. 2015-2023 ◽  
Author(s):  
Vivia V. McCutcheon ◽  
John R. Kramer ◽  
Howard J. Edenberg ◽  
John I. Nurnberger ◽  
Samuel Kuperman ◽  
...  

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