Early intervention for impairing post-concussion symptoms in adolescents and young adults: Results from a randomized trial

ABSTRACT This study evaluated the safety, tolerability, and immunogenicity of an investigational quadrivalent meningococcal conjugate vaccine, MenACWY-CRM, when administered concomitantly with a combined tetanus, reduced diphtheria, and acellular pertussis (Tdap) vaccine, in subjects aged 11 to 25 years. Subjects received either MenACWY-CRM and Tdap, MenACWY-CRM and saline placebo, or Tdap and saline placebo. No significant increase in reactogenicity and no clinically significant vaccine-related adverse events (AEs) occurred when MenACWY-CRM and Tdap were administered concomitantly. Similar immunogenic responses to diphtheria, tetanus, and meningococcal (serogroups A, C, W-135, and Y) antigens were observed, regardless of concomitant vaccine administration. Antipertussis antibody responses were comparable between vaccine groups for filamentous hemagglutinin and were slightly lower, although not clinically significantly, for pertussis toxoid and pertactin when the two vaccines were administered concomitantly. These results indicate that the investigational MenACWY-CRM vaccine is well tolerated and immunogenic and that it can be coadministered with Tdap to adolescents and young adults.

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Randomized Trial of 2 Schedules of Meningococcal B Vaccine in Adolescents and Young Adults, Canada1

Emerging Infectious Diseases ◽

10.3201/eid2603.190160 ◽

2020 ◽

Vol 26 (3) ◽

pp. 454-462

Author(s):

Joanne M. Langley ◽

Soren Gantt ◽

Caroline Quach ◽

Julie A. Bettinger ◽

Scott A. Halperin ◽

...

Keyword(s):

Young Adults ◽

Randomized Trial ◽

Adolescents And Young Adults

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Early Intervention in Mental Health for Adolescents and Young Adults: A Systematic Review

American Journal of Occupational Therapy ◽

10.5014/ajot.2018.033118 ◽

2018 ◽

Vol 72 (5) ◽

pp. 7205190040p1 ◽

Cited By ~ 4

Author(s):

Halley Read ◽

Sean Roush ◽

Donna Downing

Keyword(s):

Mental Health ◽

Systematic Review ◽

Young Adults ◽

Early Intervention ◽

Adolescents And Young Adults

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Family-Focused Treatment for Adolescents and Young Adults at High Risk for Psychosis: Results of a Randomized Trial

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2014.04.020 ◽

2014 ◽

Vol 53 (8) ◽

pp. 848-858 ◽

Cited By ~ 85

Author(s):

David J. Miklowitz ◽

Mary P. O’Brien ◽

Danielle A. Schlosser ◽

Jean Addington ◽

Kristin A. Candan ◽

...

Keyword(s):

Young Adults ◽

High Risk ◽

Randomized Trial ◽

Adolescents And Young Adults ◽

Family Focused Treatment

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Intrauterine devices and sexually transmitted infection among older adolescents and young adults in a cluster randomized trial

Journal of Pediatric and Adolescent Gynecology ◽

10.1016/j.jpag.2020.11.022 ◽

2020 ◽

Author(s):

Alison M. El Ayadi ◽

Corinne H. Rocca ◽

Sarah H. Averbach ◽

Suzan Goodman ◽

Philip D. Darney ◽

...

Keyword(s):

Young Adults ◽

Randomized Trial ◽

Sexually Transmitted Infection ◽

Cluster Randomized Trial ◽

Adolescents And Young Adults ◽

Intrauterine Devices ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Older Adolescents ◽

Cluster Randomized

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Process Evaluation of an Early-Intervention Program for Mood and Anxiety Disorders Among Older Adolescents and Young Adults

Psychiatric Services ◽

10.1176/appi.ps.201400256 ◽

2015 ◽

Vol 66 (10) ◽

pp. 1113-1117 ◽

Cited By ~ 8

Author(s):

Elizabeth A. Osuch ◽

Evelyn Vingilis ◽

Carolyn Summerhurst ◽

Christeen I. Forster ◽

Erin E. Ross ◽

...

Keyword(s):

Young Adults ◽

Early Intervention ◽

Anxiety Disorders ◽

Process Evaluation ◽

Intervention Program ◽

Adolescents And Young Adults ◽

Early Intervention Program ◽

Mood And Anxiety Disorders ◽

Older Adolescents

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“What is the efficacy of specialised early intervention in mental health targeting simultaneously adolescents and young adults?’’ An HTA

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462319000084 ◽

2019 ◽

Vol 35 (2) ◽

pp. 134-140 ◽

Cited By ~ 2

Author(s):

Angela Ly ◽

Gilbert A. Tremblay ◽

Sylvie Beauchamp

Keyword(s):

At Risk ◽

Young Adults ◽

Early Intervention ◽

Mental Healthcare ◽

Analytical Framework ◽

Adolescents And Young Adults ◽

Adult Services ◽

Care Models ◽

Age Of Majority ◽

Implementation Factors

AbstractObjectivesCurrent service organization is not adapted for youth with or at risk of mental illness. Access, engagement and continuity of care are notorious challenges, particularly during transition from adolescence to adulthood, when youths are transferred to adult services. An HTA was initiated to evaluate the efficacy of programs for which admission is not a function of the legal age of majority.MethodsA systematic review of systematic reviews identified literature published between 2000 and 2017 in 4 databases. To be selected, studies had to focus on specialised mental healthcare early intervention (EI) programs targeting both adolescents and young adults. Contextual and experiential data were collected through interviews with local leading experts. Article selection and quality assessment using ROBIS were conducted with inter rater agreement. The analytical framework developed includes 4 domains: access, engagement and continuity, recovery as well as meaningfulness and acceptability.Results1841 references were identified. Following inclusion/exclusion criteria, 5 studies were selected, 3 of which focused on EI for psyschosis. EI programs alone do not seem to decrease duration of untreated psychosis. EI including a multi focus campaign were more successful. EI does, however, seem to decrease hospitalisation for psychosis. The experience of service users and professionals with inter agency collaboration and person-centred care models were analysed to identify facilitating and inhibiting implementation factors.ConclusionsHealthcare policies need to support further research and development of EI where admission is not a function of the legal age of majority and diagnostic, particularly for youths at risk.

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