Final diagnosis and patient disposition following equivocal results on 2-mSv CT vs. conventional-dose CT in adolescents and young adults with suspected appendicitis: a post hoc analysis of large pragmatic randomized trial data

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Seungjae Lee ◽  
Hooney Daniel Min ◽  
Hae Young Kim ◽  
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2020 ◽  
Vol 9 (3) ◽  
pp. 641-656
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Johannes Beeslaar ◽  
Judith Absalon ◽  
Annaliesa S. Anderson ◽  
Joseph J. Eiden ◽  
Paul Balmer ◽  
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2017 ◽  
Vol 42 ◽  
pp. 248-254
Author(s):  
Lars W. Andersen ◽  
Xiaowen Liu ◽  
Sophia Montissol ◽  
Mathias J. Holmberg ◽  
Bjørn K. Fabian-Jessing ◽  
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Vol 17 (4) ◽  
pp. 537-544 ◽  
Author(s):  
Roberto Gasparini ◽  
Michele Conversano ◽  
Gianni Bona ◽  
Giovanni Gabutti ◽  
Alessandra Anemona ◽  
...  

ABSTRACT This study evaluated the safety, tolerability, and immunogenicity of an investigational quadrivalent meningococcal conjugate vaccine, MenACWY-CRM, when administered concomitantly with a combined tetanus, reduced diphtheria, and acellular pertussis (Tdap) vaccine, in subjects aged 11 to 25 years. Subjects received either MenACWY-CRM and Tdap, MenACWY-CRM and saline placebo, or Tdap and saline placebo. No significant increase in reactogenicity and no clinically significant vaccine-related adverse events (AEs) occurred when MenACWY-CRM and Tdap were administered concomitantly. Similar immunogenic responses to diphtheria, tetanus, and meningococcal (serogroups A, C, W-135, and Y) antigens were observed, regardless of concomitant vaccine administration. Antipertussis antibody responses were comparable between vaccine groups for filamentous hemagglutinin and were slightly lower, although not clinically significantly, for pertussis toxoid and pertactin when the two vaccines were administered concomitantly. These results indicate that the investigational MenACWY-CRM vaccine is well tolerated and immunogenic and that it can be coadministered with Tdap to adolescents and young adults.


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