The signal transduction pathways via protease activated receptor-1 (PAR-1) in human decidual stromal cells

2015 ◽  
Vol 112 ◽  
pp. 128
Author(s):  
Kaori Goto ◽  
Fumiko Kawabe ◽  
Yasushi Kawano ◽  
Takafumi Utsunomiya ◽  
Hisashi Narahara
Keyword(s):  
Signal Transduction ◽  
Stromal Cells ◽  
Signal Transduction Pathways ◽  
Protease Activated Receptor 1

scholarly journals Mesenchymal stem/stromal cells in cancer therapy

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tianxia Lan ◽  
Min Luo ◽  
Xiawei Wei
Keyword(s):  
Signal Transduction ◽  
Bone Marrow ◽  
Stromal Cells ◽  
Translational Medicine ◽  
Signal Transduction Pathways ◽  
Published Data ◽  
Efficacy And Safety ◽  
Therapeutic Mechanisms ◽  
Tumor Homing ◽  
Special Relevance

AbstractThe multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone marrow in 1976, have been identified in nearly all tissues of human body now. The multipotency of MSCs allows them to give rise to osteocytes, chondrocytes, adipocytes, and other lineages. Moreover, armed with the immunomodulation capacity and tumor-homing property, MSCs are of special relevance for cell-based therapies in the treatment of cancer. However, hampered by lack of knowledge about the controversial roles that MSC plays in the crosstalk with tumors, limited progress has been made with regard to translational medicine. Therefore, in this review, we discuss the prospects of MSC-associated anticancer strategies in light of therapeutic mechanisms and signal transduction pathways. In addition, the clinical trials designed to appraise the efficacy and safety of MSC-based anticancer therapies will be assessed according to published data.

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

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