Serum cardiac troponin T, troponin I, plasma BNP and left ventricular mass index in professional football players

Objective.To study the association of serum cardiac troponin T (cTnT) and cardiac troponin I (cTnI) with creatine kinase (CK) in patients with idiopathic inflammatory myopathies (IIM).Methods.We performed a retrospective study on patients with IIM followed by the rheumatology service of a county hospital from 2004 to 2008. Patients with myocardial ischemia and/or with renal failure were excluded. Clinical data including electromyogram, muscle biopsy, and CK, cTnT and cTnI were recorded. Patients who had simultaneous analysis of CK and cardiac troponin (cTnT or cTnI) levels were studied. CK levels were correlated with cTnT and cTnI by chi-square test and Spearman correlation.Results.We identified 49 patients with IIM (69 observations) who satisfied our inclusion criteria. The primary diagnosis was polymyositis in 23, dermatomyositis in 16, and myositis associated with connective tissue disease in 10 patients. There were 33/49 women with average age 45.8 years. Twenty-eight patients with IIM had simultaneous CK and cTnT values assayed. Of those patients, 18/23 with elevated CK also had elevated cTnT, and 5/5 patients with normal CK levels had normal cTnT levels (p = 0.005). In 41 patients with IIM who had simultaneous CK and cTnI levels assayed, only 1/29 with elevated CK had elevated cTnI, and 12/12 patients with normal CK had normal cTnI (p = 0.5). CK correlated strongly with the cTnT (r = 0.62, p = 0.001) but did not correlate with cTnI.Conclusion.Elevated cTnT, but not cTnI, was highly associated with CK in patients with IIM despite the absence of myocardial ischemia.

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P3433 The inter-relationship between cardiac troponin I, left-ventricular mass index and outcomes in patients with end-stage renal disease

European Heart Journal ◽

10.1016/s0195-668x(03)96059-3 ◽

2003 ◽

Vol 24 (5) ◽

pp. 663

Author(s):

A ABACI

Keyword(s):

Renal Disease ◽

Left Ventricular Mass ◽

End Stage Renal Disease ◽

Cardiac Troponin ◽

Left Ventricular Mass Index ◽

Troponin I ◽

Left Ventricular ◽

Cardiac Troponin I ◽

Stage Renal Disease ◽

End Stage

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Relationships of N-Terminal Pro–B-Natriuretic Peptide and Cardiac Troponin T to Left Ventricular Mass and Function and Mortality in Asymptomatic Hemodialysis Patients

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2007.08.017 ◽

2007 ◽

Vol 50 (6) ◽

pp. 1009-1019 ◽

Cited By ~ 85

Author(s):

Sangeetha Satyan ◽

Robert P. Light ◽

Rajiv Agarwal

Keyword(s):

Left Ventricular Mass ◽

Natriuretic Peptide ◽

Cardiac Troponin ◽

Troponin T ◽

Hemodialysis Patients ◽

Left Ventricular ◽

Cardiac Troponin T ◽

Ventricular Mass ◽

And Function

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Clinical, serum cardiac troponin T and echocardiographic evaluation for prediction of late doxorubicin cardiotoxicity

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.9536 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 9536-9536

Author(s):

E. C. Benites ◽

M. G. Paiva ◽

A. M. Cappellano ◽

O. M. Felix ◽

S. B. Marinelli ◽

...

Keyword(s):

Cardiac Troponin ◽

Troponin T ◽

Elevated Serum ◽

Clinical Signs ◽

Dobutamine Stress ◽

Left Ventricular ◽

Cardiac Troponin T ◽

Group A ◽

Group B ◽

Serum Cardiac Troponin

9536 Background: To evaluate whether clinical signs or symptoms of congestive heart failure, serial assessment of systolic and diastolic cardiac function by low dose dobutamine stress echo (LDSE) and serum cardiac troponin T (cTnT) can predict doxorubicin (DOXO) cardiotoxicity. Methods: Twenty five patients with osteosarcoma enrolled in the Brazilian osteosarcoma treatment group study 2000, from january 2000 to may 2004, were studied with LDSE (>5μg/kg/min) before chemotherapy, 160 mg/m2 DOXO and after 160 mg/m2 DOXO. cTnT were measured before and during DOXO infusion. Cardiotoxicity was defined as shortening fraction (SF) less than 30% assessed by rest echo 1 to 6 months off chemotherapy. Group A comprised those without cardiotoxicity (16 patients, 10 male, 14.3 ± 4.7 years) whereas group B included those with a SF < 30% (9 patients, 6 male, 15.4 ± 3 years). Elevated serum cTnT was defined as seric levels above 0.01ng/ml. Results: Patients were submitted to a mean 3.4 LDSE and a mean of 32.5 serum cTnT. One patient (group B) presented clinical manifestation of cardiotoxicity. There was no statistical difference of elevated serum cTnT between the group B and group A (87.5% vs 46.2%; p=0,06). Left ventricular dimensions by M- MODE and transmitral Doppler inflow diastolic parameters were not significantly different between the two groups. Resting SF showed comparable values in both groups until cumulative doses of DOXO reached 160mg/m2, then the resting SF in group B was significant lower than group A (27% ± 2 and 34.1% ± 2, p<0.01). During dobutamine infusion, SF and ΔSF (dobutamine-rest) were significantly lower in group B as compared to group A at a DOXO dose 160mg/m2 (SF 36.1%±3,4 and ΔSF 2.1±2.3 vs. SF 45.2%±4.9 and ΔSF 9.4±3; p< 0.01 and p < 0.01) as well as at a DOXO dose > 160mg/m2 (30.3%±3 and 3.1±1.9 vs. 40.8%±5.9 and 7.2±4.2;p<0.01 and p<0.01). Conclusions: This study suggests that LDSE is more reliable than cTnT and clinical evaluation for predicting future subclinical cardiotoxicity,even at lower doxorubicin dose. No significant financial relationships to disclose.

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