Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients

Objective The prevalence of left ventricular hypertrophy (LVH) reaches 75% in patients with end-stage renal disease. In patients on peritoneal dialysis (PD), some factors, such as hypertension, volume overload, serum albumin, and residual renal function, have been reported to be related to LVH. Dyslipidemia often occurs in PD but it remains unclear whether dyslipidemia is related to LVH. We investigated the relationship between clinical parameters, including lipid profile, and left ventricular mass index (LVMI). Methods In this cross-sectional study, 34 patients undergoing PD for more than 1 year without combined therapy with hemodialysis were included. We recorded the patients’ clinical data and related those parameters with LVMI as evaluated by echocardiography. Results The patients included 23 males and 11 females (age 62.2 ± 12.1 years, duration on PD 31.6 ± 15.6 months). Mean LVMI was 142 ± 37 g/m2. In univariate analysis, urine volume ( r = -0.493, p = 0.003), total cholesterol ( r = -0.418, p = 0.01), high-density lipoprotein cholesterol (HDL-C; r = -0.374, p = 0.02), and human atrial natriuretic peptide (hANP; r = 0.600, p < 0.001) significantly correlated with LVMI. Stepwise multiple regression analysis showed that hANP (β= 0.524, p = 0.001) and HDL-C (β= -0.422, p = 0.007) were independently associated with LVMI ( r2 = 0.32). Conclusion Strict volume control and salt restriction is essential for prevention of LVH. The role of HDL-C in the development of LVH in PD patients remains to be determined.

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Divergent Effects of Hemodialysis and Continuous Ambulatory Peritoneal Dialysis on Cardiac Diastolic Function

Peritoneal Dialysis International ◽

10.1177/089686089701700410 ◽

1997 ◽

Vol 17 (4) ◽

pp. 353-359 ◽

Cited By ~ 6

Author(s):

Günter Weiss ◽

Karl Lhotta ◽

Gilbert Reibnegger ◽

Paul König ◽

Edwin Knapp

Keyword(s):

Peritoneal Dialysis ◽

Diastolic Function ◽

Left Ventricular Mass ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Left Ventricular ◽

Cardiac Performance ◽

Matched Pair ◽

Dialysis Patients ◽

Ventricular Mass ◽

Patient Groups

Objective To investigate the effects of dialysis procedures on cardiac diastolic function. Design Comparative, nonrandomized matched pair study. Setting Nephrology and cardiology departments at a university hospital. Patients Thirty-four patients on hemodialysis (HD) (n = 17) and continuous ambulatory peritoneal dialysis (CAPD) (n = 17), matched by sex, age, duration of dialysis treatment, and presence/absence of diabetes. Measurements Cardiac function was estimated by means of M-mode, two-dimensional, and spectral Dopplerechocardiography, and results were statisticallyevalu-ated by means of univariate and multivariate analytical procedures. Results Although not statistically significant, trends towards differences between the two patient groups were detected for left ventricular mass (p = 0.083) and parameters of diastolic function (p = 0.079). These differences in left ventricular performance and diastolic function between HD and CAPD patients were also evident when calculating Spearman rank correlation coefficients. Left ventricular mass and diastolic function were closely correlated to each other in all dialysis patients. Moreover, by means of a multivariate analytical procedure (Hotelling T square test), diversities in diastolic function between the two patient groups could be clearly established (p = 0.037), with more impaired diastolic function in HD patients. In addition, cardiac performance was shown to depend to a certain extent on hemoglobin concentration. Conclusion Clear differences in diastolic function and cardiac performance were evident between CAPD and HD patients. From the data of our pilot study, it may be speculated whether decrease of left ventricular mass could be beneficial for the improvement of diastolic function and cardiac hemodynamics in dialysis patients.

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