The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities

2004 ◽  
Vol 92 (3) ◽  
pp. 119-130 ◽  
Author(s):  
Peter Lee-Robichaud ◽  
Monika E. Akhtar ◽  
J. Neville Wright ◽  
Qaiser I. Sheikh ◽  
Muhammad Akhtar
Keyword(s):  
Cytochrome B5 ◽  
Acyl Carbon ◽  
Human Cytochrome ◽  
Cytochrome P450c17

scholarly journals Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141252 ◽  
Author(s):  
Alexandr N. Simonov ◽  
Jessica K. Holien ◽  
Joyee Chun In Yeung ◽  
Ann D. Nguyen ◽  
C. Jo Corbin ◽  
...  
Keyword(s):  
Cytochrome B5 ◽  
Human Cytochrome ◽  
Cytochrome P450c17

Generation of superoxide radical by human cytochrome b5 reductase is modulated by cytochrome b5

2018 ◽  
Vol 128 ◽  
pp. S42
Author(s):  
Murugesan Velayutham ◽  
Eric Cecco ◽  
Sruti Shiva ◽  
Mark Gladwin ◽  
Courtney Sparacino-Watkins
Keyword(s):  
Superoxide Radical ◽  
Cytochrome B5 ◽  
Cytochrome B5 Reductase ◽  
Human Cytochrome

Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

2015 ◽  
Vol 87 (4) ◽  
pp. 733-739 ◽  
Author(s):  
Colin J. Henderson ◽  
Lesley A. McLaughlin ◽  
Nico Scheer ◽  
Lesley A. Stanley ◽  
C. Roland Wolf
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome B5 ◽  
Major Determinant ◽  
Cyp3a4 Activity ◽  
Human Cytochrome

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively

1993 ◽  
Vol 92 (6) ◽  
pp. 615-618 ◽  
Author(s):  
Sara J. Giordano ◽  
Min Yoo ◽  
David C. Ward ◽  
Madhvi Bhatt ◽  
Joan Overhauser ◽  
...  
Keyword(s):  
Cytochrome B5 ◽  
Human Cytochrome
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