Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2004.07.005 ◽

2004 ◽

Vol 92 (3) ◽

pp. 119-130 ◽

Cited By ~ 26

Author(s):

Peter Lee-Robichaud ◽

Monika E. Akhtar ◽

J. Neville Wright ◽

Qaiser I. Sheikh ◽

Muhammad Akhtar

Keyword(s):

Cytochrome B5 ◽

Acyl Carbon ◽

Human Cytochrome ◽

NADH:cytochrome b5 reductase and cytochrome b5 act as sole electron donors to human cytochrome P450 1A1-catalyzed oxidation and DNA adduct formation by benzo[a]pyrene

Toxicology Letters ◽

10.1016/j.toxlet.2016.06.1417 ◽

2016 ◽

Vol 258 ◽

pp. S96

Author(s):

M. Stiborova ◽

I. Radek ◽

M. Moserova ◽

E. Frei ◽

K. Kopka ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Adduct Formation ◽

Dna Adduct ◽

Electron Donors ◽

Cytochrome P450 1A1 ◽

Human Cytochrome ◽

Catalyzed Oxidation

Generation of superoxide radical by human cytochrome b5 reductase is modulated by cytochrome b5

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2018.10.064 ◽

2018 ◽

Vol 128 ◽

pp. S42

Author(s):

Murugesan Velayutham ◽

Eric Cecco ◽

Sruti Shiva ◽

Mark Gladwin ◽

Courtney Sparacino-Watkins

Keyword(s):

Superoxide Radical ◽

Cytochrome B5 ◽

Cytochrome B5 Reductase ◽

Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

Molecular Pharmacology ◽

10.1124/mol.114.097394 ◽

2015 ◽

Vol 87 (4) ◽

pp. 733-739 ◽

Cited By ~ 22

Author(s):

Colin J. Henderson ◽

Lesley A. McLaughlin ◽

Nico Scheer ◽

Lesley A. Stanley ◽

C. Roland Wolf

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Major Determinant ◽

Cyp3a4 Activity ◽

Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Protein Expression and Purification ◽

10.1006/prep.2001.1578 ◽

2002 ◽

Vol 24 (3) ◽

pp. 329-337 ◽

Cited By ~ 180

Author(s):

Hiroshi Yamazaki ◽

Mami Nakamura ◽

Tomoko Komatsu ◽

Katsuhiro Ohyama ◽

Naoya Hatanaka ◽

...

Keyword(s):

Escherichia Coli ◽

Cytochrome B5 ◽

Cytochrome P450s ◽

P450 Reductase ◽

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively

Human Genetics ◽

10.1007/bf00420948 ◽

1993 ◽

Vol 92 (6) ◽

pp. 615-618 ◽

Cited By ~ 9

Author(s):

Sara J. Giordano ◽

Min Yoo ◽

David C. Ward ◽

Madhvi Bhatt ◽

Joan Overhauser ◽

...

Keyword(s):

Cytochrome B5 ◽

Co-expression of human cytochrome b5 increases expression of cytochrome P450 3A4 in Escherichia coli by stabilizing mRNA

Protein Expression and Purification ◽

10.1016/j.pep.2013.02.010 ◽

2013 ◽

Vol 89 (1) ◽

pp. 44-50 ◽

Cited By ~ 5

Author(s):

Mi-Sook Dong ◽

Sang-Bum Lee ◽

Hyun-Jung Kim

Keyword(s):

Escherichia Coli ◽

Cytochrome P450 ◽

Cytochrome B5 ◽

Cytochrome P450 3A4 ◽

Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.77.2.489 ◽

1993 ◽

Vol 77 (2) ◽

pp. 489-493 ◽

Cited By ~ 12

Author(s):

C. E. Fardella

Keyword(s):

Amino Acids ◽

Hydroxylase Deficiency ◽

Human Cytochrome ◽

The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100)

Mutagenesis ◽

10.1093/mutage/gel054 ◽

2006 ◽

Vol 22 (1) ◽

pp. 75-81 ◽

Cited By ~ 10

Author(s):

M. P. Duarte ◽

B. B. Palma ◽

A. A. Gilep ◽

A. Laires ◽

J. S. Oliveira ◽

...

Keyword(s):

Cytochrome P450 ◽

Expression System ◽

Cytochrome B5 ◽

Human Cytochrome ◽

Cell Expression ◽

Human Cyp1a2 ◽

Cell Expression System

Phosphorylation of Human Cytochrome P450c17 by p38α Selectively Increases 17,20 Lyase Activity and Androgen Biosynthesis

Journal of Biological Chemistry ◽

10.1074/jbc.m113.460048 ◽

2013 ◽

Vol 288 (33) ◽

pp. 23903-23913 ◽

Cited By ~ 37

Author(s):

Meng Kian Tee ◽

Walter L. Miller

Keyword(s):

Human Cytochrome ◽

Lyase Activity ◽