scholarly journals Revealing facts behind spray dried solid dispersion technology used for solubility enhancement

2015 ◽  
Vol 23 (4) ◽  
pp. 352-365 ◽  
Author(s):  
Bhavesh B. Patel ◽  
Jayvadan K. Patel ◽  
Subhashis Chakraborty ◽  
Dali Shukla
Keyword(s):  
Solid Dispersion ◽  
Solubility Enhancement ◽  
Spray Dried

scholarly journals Particle Engineering and Spray Drying Process designing for Solubility Enhancement of Lopinavir

2021 ◽  
Vol 11 (5) ◽  
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Study Drug ◽  
Entrapment Efficiency ◽  
Solubility Enhancement ◽  
Particle Engineering ◽  
Solubility Study ◽  
Dissolution Studies ◽  
Dissolution Tests ◽  
Spray Dried

To improve the solubility enhancement of solid dispersion of Lopinavir by spray-drying by adding the Soluplus as polymer that is compatible with Lopinavir, was evaluated and the process used for preparation of Spray dried solid dispersion was validated and the 1:3 ratio used for preparation of solid dispersion. Dissolution tests were carried out on several spray dried solid dispersion of Lopinavir and physical mixture. The solid dispersion characterized by DSC, XRD, % Entrapment Efficiency, solubility study, drug content determination, practical yield, dissolution studies. Keyword: Lopinavir, Soluplus, Spray Drying Technique, Dissolution studies

scholarly journals Water Solubility Enhancement of Atorvastatin by Solid Dispersion Method

1970 ◽  
Vol 3 (2) ◽  
pp. 43-46
Author(s):  
Riaz Uddin ◽  
Farzana Ali ◽  
Subrata Kumar Biswas
Keyword(s):  
Key Words ◽  
Solid Dispersion ◽  
Water Solubility ◽  
Solid Dispersions ◽  
Solubility Enhancement ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Dispersion Method ◽  
Evaporation Method

Key Words: Solid dispersions; solvent evaporation method; atorvastatin; HPMCDOI: http://dx.doi.org/10.3329/sjps.v3i2.8036 S.J. Pharm. Sci 3(2): 43-46

scholarly journals Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers

2007 ◽  
Vol 57 (3) ◽  
pp. 287-300 ◽  
Author(s):  
Ravindra Dhumal ◽  
Shamkant Shimpi ◽  
Anant Paradkar
Keyword(s):  
Hydrogen Bonding ◽  
Solid Dispersion ◽  
Dissolution Profile ◽  
Scanning Calorimetry ◽  
Unit Operations ◽  
Bonding Interaction ◽  
Amorphous Drugs ◽  
The Stability ◽  
Amorphous Drug ◽  
Spray Dried

Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizersThe purpose of this study was to obtain an amorphous system with minimum unit operations that will prevent recrystallization of amorphous drugs since preparation, during processing (compression) and further storage. Amorphous celecoxib, solid dispersion (SD) of celecoxib with polyvinyl pyrrollidone (PVP) and co-precipitate with PVP and carrageenan (CAR) in different ratios were prepared by the spray drying technique and compressed into tablets. Saturation solubility and dissolution studies were performed to differentiate performance after processing. Differential scanning calorimetry and X-ray powder difraction revealed the amorphous form of celecoxib, whereas infrared spectroscopy revealed hydrogen bonding between celecoxib and PVP. The dissolution profile of the solid dispersion and co-precipitate improved compared to celecoxib and amorphous celecoxib. Amorphous celecoxib was not stable on storage whereas the solid dispersion and co-precipitate powders were stable for 3 months. Tablets of the solid dispersion of celecoxib with PVP and physical mixture with PVP and carrageenan showed better resistance to recrystallization than amorphous celecoxib during compression but recrystallized on storage. However, tablets of co-precipitate with PVP and carageenan showed no evidence of crystallinity during stability studies with comparable dissolution profiles. This extraordinary stability of spray-dried co-precipitate tablets may be attributed to the cushioning action provided by the viscoelastic polymer CAR and hydrogen bonding interaction between celecoxib and PVP. The present study demonstrates the synergistic effect of combining two types of stabilizers, PVP and CAR, on the stability of amorphous drug during compression and storage as compared to their effect when used alone.

Combination of Colloidal Silicon Dioxide with Spray-Dried Solid Dispersion to Facilitate Discharge from an Agitated Dryer

2019 ◽  
Vol 20 (5) ◽  
Author(s):  
Yung-Chi Lee ◽  
Michael McNevin ◽  
Craig Ikeda ◽  
Georgia Chouzouri ◽  
Justin Moser ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Solid Dispersion ◽  
Spray Dried

scholarly journals Preparation and characterization of spray-dried valsartan-loaded Eudragit® E PO solid dispersion microparticles

2016 ◽  
Vol 11 (6) ◽  
pp. 744-750 ◽  
Author(s):  
Roshan Pradhan ◽  
Sung Yub Kim ◽  
Chul Soon Yong ◽  
Jong Oh Kim
Keyword(s):  
Solid Dispersion ◽  
Spray Dried
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