Effect of co-existent components in CO2 supercritical fluid extract of Angelica Sinensis Radix on metabolism of Z-ligustilide after oral administration in rats

Inflammatory bowel disease (IBD) is a worldwide healthcare problem calling for the development of new therapeutic drugs. Angelica sinensis and Zingiber officinale Roscoe are two common dietetic Chinese herbs, which are traditionally used for complementary treatment of gastrointestinal disorders. As bioactive constituents, volatile and pungent substances of these two herbs could be effectively extracted together by supercritical fluid extraction. In this study, the supercritical fluid extract of Angelica sinensis and Zingiber officinale Roscoe (AZ-SFE) was obtained by an optimized extraction process and it was chemically characterized. The anti-inflammatory effect and underlying mechanism of AZ-SFE were evaluated in a lipopolysaccharide (LPS)-induced RAW264.7 cell model and a 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model. AZ-SFE notably inhibited the production of NO in LPS-stimulated macrophages, and it inhibited the proliferation of Concanavalin A (Con A)-induced splenocytes with suppression of the Th1 immune response. In vivo, the study demonstrated that AZ-SFE significantly alleviated disease activity, colonic shortening, macroscopic damage and histological injury of TNBS-treated rats with reduction of oxidative stress, suppression of inflammatory cytokines, and modulation of hepcidin and serum iron. These findings suggested that AZ-SFE may be a promising supplement for current IBD therapy.

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Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix

Journal of Ethnopharmacology ◽

10.1016/j.jep.2014.05.007 ◽

2014 ◽

Vol 154 (3) ◽

pp. 825-831 ◽

Cited By ~ 6

Author(s):

Janis Ya-xian Zhan ◽

Ken Yu-zhong Zheng ◽

Wendy Li Zhang ◽

Jian-ping Chen ◽

Ping Yao ◽

...

Keyword(s):

Biological Properties ◽

Angelica Sinensis ◽

Astragali Radix ◽

Danggui Buxue Tang ◽

Chinese Herbal ◽

Herbal Decoction ◽

Angelica Sinensis Radix

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Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern

Journal of Analytical Methods in Chemistry ◽

10.1155/2020/8836184 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Xi Li ◽

Yixin Yao ◽

Xiaoxiao Wang ◽

Chang An ◽

Shanshan Gao ◽

...

Keyword(s):

Mass Spectrometry ◽

Phenolic Acids ◽

Inductively Coupled Plasma ◽

Angelica Sinensis ◽

Inorganic Elements ◽

Organic Components ◽

Chemical Recognition ◽

Significant Difference ◽

Angelica Sinensis Radix ◽

Different Parts

Angelica Sinensis Radix (Danggui, DG) is one of the most commonly prescribed traditional Chinese medicines. The organic components include phthalides and phenolic acids. Meanwhile, inorganic elements play an important role in clinical effect. DG and its different parts have different effects. There is no relevant report on the analysis of organic compounds and inorganic elements among them. Therefore, ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed for the simultaneous determination of 13 organic components (8 phthalides and 5 phenolic acids), and 8 inorganic elements were determined by inductively coupled plasma mass spectrometry. The contents of 32 samples were analyzed by orthogonal partial least squares discrimination analysis, hierarchical cluster analysis, and least-significant difference of one-way analysis of variance. The results showed that the differences were significant among DG and its different parts. 11 difference markers (Ca, Z-ligustilide, Mg, Mn, Fe, Na, K, Cu, Zn, coniferyl ferulate, and senkyunolide A) were obtained by variable importance for the project. These difference markers were some different among DG and its different parts, especially Z‐ligustilide, coniferyl ferulate, Mg, Zn, the differences were significant. This study can provide a reference for DG research.

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Importance of Wine-Treated Angelica Sinensis Radix in Si Wu Tang, a Traditional Herbal Formula for Treating Womenʼs Ailments

Planta Medica ◽

10.1055/s-0032-1328261 ◽

2013 ◽

Vol 79 (07) ◽

pp. 533-537 ◽

Cited By ~ 8

Author(s):

Janis Zhan ◽

Ken Zheng ◽

Kevin Zhu ◽

Wendy Zhang ◽

Cathy Bi ◽

...

Keyword(s):

Angelica Sinensis ◽

Herbal Formula ◽

Angelica Sinensis Radix

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Prescription Pattern of Chinese Herbal Products for Breast Cancer in Taiwan: A Population-Based Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/891893 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 42

Author(s):

Jung-Nien Lai ◽

Chien-Tung Wu ◽

Jung-Der Wang

Keyword(s):

Breast Cancer ◽

Panax Ginseng ◽

Synergistic Effects ◽

Symptom Relief ◽

Healthcare Providers ◽

Angelica Sinensis ◽

Research Database ◽

Herbal Products ◽

Chinese Herbal ◽

Angelica Sinensis Radix

Background. Chinese herbal products (CHPs) given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan.Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs) for utilization of CHP.Results. 81.5 percent (N=2,236) of women with breast cancer utilized traditional Chinese medicine (TCM) and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder) was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix) and six contained ren shen (Panax ginseng-radix), which are reported to have potential beneficial synergistic effects on breast cancer cells.Conclusion. CHP containing dang qui (Angelica sinensis-radix) or ren shen (Panax ginseng-radix) are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers.

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