Trace elements in children with autism spectrum disorder: a meta-analysis based on case-control studies

2021 ◽  
pp. 126782
Author(s):  
Jun Zhang ◽  
Xi Li ◽  
Liming Shen ◽  
Naseer Ullah Khan ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Trace Elements ◽  
Meta Analysis ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Case Control Studies

scholarly journals The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 86
Author(s):  
Zuqun Wang ◽  
Rui Ding ◽  
Juan Wang
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Vitamin D Status ◽  
Case Control Studies ◽  
Lower Vitamin

The association between vitamin D status and autism spectrum disorder (ASD) is well-investigated but remains to be elucidated. We quantitatively combined relevant studies to estimate whether vitamin D status was related to ASD in this work. PubMed, EMBASE, Web of Science, and the Cochrane Library were searched to include eligible studies. A random-effects model was applied to pool overall estimates of vitamin D concentration or odds ratio (OR) for ASD. In total, 34 publications involving 20,580 participants were identified in this present study. Meta-analysis of 24 case–control studies demonstrated that children and adolescents with ASD had significantly lower vitamin D concentration than that of the control group (mean difference (MD): −7.46 ng/mL, 95% confidence interval (CI): −10.26; −4.66 ng/mL, p < 0.0001, I2 = 98%). Quantitative integration of 10 case–control studies reporting OR revealed that lower vitamin D was associated with higher risk of ASD (OR: 5.23, 95% CI: 3.13; 8.73, p < 0.0001, I2 = 78.2%). Analysis of 15 case–control studies barring data from previous meta-analysis reached a similar result with that of the meta-analysis of 24 case–control studies (MD: −6.2, 95% CI: −9.62; −2.78, p = 0.0004, I2 = 96.8%), which confirmed the association. Furthermore, meta-analysis of maternal and neonatal vitamin D showed a trend of decreased early-life vitamin D concentration in the ASD group (MD: −3.15, 95% CI: −6.57; 0.26, p = 0.07, I2 = 99%). Meta-analysis of prospective studies suggested that children with reduced maternal or neonatal vitamin D had 54% higher likelihood of developing ASD (OR: 1.54, 95% CI: 1.12; 2.10, p = 0.0071, I2 = 81.2%). These analyses indicated that vitamin D status was related to the risk of ASD. The detection and appropriate intervention of vitamin D deficiency in ASD patients and pregnant and lactating women have clinical and public significance.

Hair toxic and essential trace elements in children with autism spectrum disorder

2016 ◽  
Vol 32 (1) ◽  
pp. 195-202 ◽  
Author(s):  
Anatoly V. Skalny ◽  
Natalia V. Simashkova ◽  
Tatiana P. Klyushnik ◽  
Andrei R. Grabeklis ◽  
Geir Bjørklund ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Trace Elements ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Essential Trace Elements

Plasma concentrations of the trace elements copper, zinc and selenium in Brazilian children with autism spectrum disorder

2018 ◽  
Vol 106 ◽  
pp. 605-609 ◽  
Author(s):  
Paula Fabiana Saldanha Tschinkel ◽  
Geir Bjørklund ◽  
Lourdes Zélia Zanoni Conón ◽  
Salvatore Chirumbolo ◽  
Valter Aragão Nascimento
Keyword(s):  
Autism Spectrum Disorder ◽  
Trace Elements ◽  
Plasma Concentrations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Copper Zinc ◽  
Brazilian Children

Comparing sleep patterns between children with autism spectrum disorder and children with typical development: A matched case–control study

Autism ◽  
2020 ◽  
Vol 24 (8) ◽  
pp. 2298-2303
Author(s):  
Andy CY Tse ◽  
CCW Yu ◽  
Paul H Lee
Keyword(s):  
Body Mass Index ◽  
Autism Spectrum Disorder ◽  
Body Mass ◽  
Sleep Onset ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Typical Development ◽  
Matched Case

Children with autism spectrum disorder are often reported to have more sleep deficits and poorer sleep quality compared with children with typical development. However, most previous studies have serious methodological limitations, such as varying sample sizes in the comparison groups, wide age range of participants, and body mass index not matched between participants. This study investigated whether sleep patterns differed between children with autism spectrum disorder and those with typical development using a carefully matched case–control design and incorporating both actigraphy and sleep log assessments. A total of 78 children diagnosed with autism spectrum disorder were matched with 78 typical development controls in this study. The matched variables included age, gender, and body mass index. The results showed that children with autism spectrum disorder had shorter sleep duration, reduced sleep efficiency, longer sleep-onset latency, and longer wake after sleep onset than children with typical development ( ps < 0.05). Further studies are needed to explore the mechanisms underlying these sleep deficits in children with autism spectrum disorder. Lay abstract This study compared the sleep pattern between children with autism spectrum disorders and children with typical development using a matched case–control design (matched age, gender, and body mass index). Significant differences were found in night-time sleep duration (total amount of sleep at night), sleep efficiency (percentage of time spent asleep), sleep-onset latency (length of time that it takes to transit from awake to asleep), and wake after sleep onset (total amount of time spent awake after defined sleep onset). Findings showed that children with autism spectrum disorder had poorer sleep quality than children with typical development. Mechanisms underlying the differences should be further explored in order to develop an effective treatment intervention.

The Effect of Different Intervention Approaches on Gross Motor Outcomes of Children With Autism Spectrum Disorder: A Meta-Analysis

2019 ◽  
Vol 36 (4) ◽  
pp. 501-526 ◽  
Author(s):  
Layne Case ◽  
Joonkoo Yun
Keyword(s):  
Autism Spectrum Disorder ◽  
Meta Analysis ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Effect Sizes ◽  
Inclusion Criteria ◽  
Gross Motor ◽  
Motor Outcomes ◽  
Potential Moderator

Despite the rising interest in intervention for children with autism spectrum disorder, the extent to which interventions are effective on gross motor outcomes is currently unknown. The purpose of this study was to analyze the effect of different intervention approaches on gross motor outcomes among children with autism spectrum disorder using meta-analysis. A total of 18 studies met the inclusion criteria for quantitative analysis. Pre- and posttest means and SD s were extracted to calculate effect sizes. Potential moderator variables were chosen based on important intervention characteristics. The results suggest that interventions have a large effect on gross motor outcomes among children with autism spectrum disorder (δ = 0.99, SE  = 0.19, p  < .001, 95% confidence interval [0.62, 1.36]). The interventions that were 16 total hours or longer had a significantly larger effect than those less than 16 hr. In addition, the interventions in experimental settings had significantly larger effects than the interventions in practical settings. Future interventions should consider intensity, including not only the duration of the intervention but also the intensity in which specific intervention goals are targeted.

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