Agonist of TRPM8 channel, menthol, facilitates the initiation of thermoregulatory responses to external cooling

Cooling is the best preservation method than others because the food that has been cooled will remain fresh and will not experience a change in taste, color and aroma, besides all the activities that cause decay will stop so that the cooled food will last longer. (Hartanto, 1984). With the proper cooling engine planning, it can help with spatial adjustments, adjustments to loading, estimation of the power to be used, and budget plans. That is what is commonly called the cooling load calculation. Calculation of cooling load needs to be carried out before planning. This is necessary because the magnitude of the pending load is very influential on the selection of the cooling engine so that the freezing point for preserving food can be accurate. Pendiginan burden is influenced by external and internal factors. With the experimental method, it is obtained the results of the external cooling load as the external cooling load is 11.6 kW, the inner cooling load is 138.8 kW and the performance work coefficient (COP) is 2.

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Faculty Opinions recommendation of Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718099478.793517581 ◽

2016 ◽

Author(s):

Shaun Morrison

Keyword(s):

External Cooling

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Heat balance and thermoregulatory responses in pinnaless rabbits

Journal of Thermal Biology ◽

10.1016/0306-4565(80)90038-8 ◽

1980 ◽

Vol 5 (1) ◽

pp. 37-39 ◽

Cited By ~ 1

Author(s):

M. Caputa ◽

W. Kądziela ◽

J. Narąbski

Keyword(s):

Heat Balance ◽

Thermoregulatory Responses

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Effect of K-wire Reuse and Drill Mode on Heat Generation in Bone

Hand ◽

10.1177/15589447211003172 ◽

2021 ◽

pp. 155894472110031

Author(s):

Muturi G. Muriuki ◽

Arun K. Reddy ◽

Alex Tauchen ◽

Robert M. Havey ◽

Avinash G. Patwardhan ◽

...

Keyword(s):

Cell Death ◽

Cortical Bone ◽

Heat Generation ◽

Kirschner Wire ◽

Heat Exposure ◽

Critical Temperatures ◽

Rotary Drilling ◽

External Cooling ◽

K Wires ◽

Oscillating Mode

Background We examined the effect of Kirschner wire (K-wire) reuse and use of oscillating mode on heat generation within cortical bone. Methods Two trocar-tipped K-wires were drilled through the diaphysis of each of 30 human metacarpals and phalanges: one K-wire was inserted in rotary mode and another in oscillating mode. Each wire was reused once. Thermocouples placed within the dorsal and volar bone adjacent to the K-wire drill path measured temperatures throughout each test. Results Peak cortex temperatures were 25°C to 164°C. Rotary drilling achieves peak temperatures quicker (31 ± 78 seconds vs 44 ± 78 seconds, P = .19) than oscillating drilling, but insertion time is also less, resulting in lower overall heat exposure. This effect is also seen when the K-wire is reused (34 ± 70 seconds vs 41 ± 85 seconds, P = .4). The length of time that cortical bone was exposed to critical temperatures (47°C or more) was significantly higher when a wire was reused (36 ± 72 seconds vs 43 ± 82 seconds, P = .008). Peak temperatures greater than 70°C (a temperature associated with instantaneous cell death) were observed on many occasions. Conclusions Overall heat exposure may be higher if a K-wire is reused or inserted in oscillating mode. In the absence of external cooling, K-wire insertion into cortical bone can easily expose bone to temperatures that exceed 70°C and may increase the risk of osteonecrosis.

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