scholarly journals PIN44 Cost-Effectiveness of Quadrivalent HPV Vaccination in Germany Using A Dynamic Transmission Model

2011 ◽  
Vol 14 (7) ◽  
pp. A273
Author(s):  
D. Schobert ◽  
V. Remy ◽  
O. Schöffski
Keyword(s):  
Cost Effectiveness ◽  
Hpv Vaccination ◽  
Transmission Model ◽  
Dynamic Transmission Model

scholarly journals Impact and cost-effectiveness of nonavalent human papillomavirus vaccination in Switzerland: insights from a dynamic transmission model

2019 ◽  
Author(s):  
Maurane Riesen ◽  
Johannes A. Bogaards ◽  
Nicola Low ◽  
Christian L. Althaus
Keyword(s):  
Cervical Cancer ◽  
Sensitivity Analysis ◽  
Cost Effectiveness ◽  
Hpv Vaccination ◽  
Quadrivalent Vaccine ◽  
Transmission Model ◽  
Price Difference ◽  
Dynamic Transmission Model ◽  
Hpv Types ◽  
The Impact

ABSTRACTAIMIn Switzerland, human papillomavirus (HPV) vaccination has been implemented using a quadrivalent vaccine that covers HPV types 16 and 18, responsible for about 70% of cervical cancer. The average national uptake was 56% in girls by the age of 16 years in 2014–2016. A nonavalent vaccine, covering five additional oncogenic HPV types was recommended at the end of 2018. The primary aim of this study was to assess the impact and cost-effectiveness of introducing the nonavalent HPV vaccine in Switzerland compared with the quadrivalent vaccine.METHODSWe developed a dynamic transmission model that describes the spread of 10 high risk HPV types. We informed the model with Swiss data about sexual behaviour and cervical cancer screening, and calibrated the model to cervical cancer incidence in Switzerland. We modelled the impact of quadrivalent and nonavalent vaccines at the achieved (56%) and national recommended uptake (80%) in girls. We calculated the incremental cost-effectiveness ratio (ICER) between the nonavalent vaccine, the quadrivalent vaccine and no vaccination. We evaluated costs linked to cervical cancer screening, treatment of different disease stages and vaccination in a sensitivity analysis.RESULTSCompared with quadrivalent HPV vaccination in Switzerland at 56% uptake, vaccinating with the nonavalent vaccine would avert 1,175 cervical cancer deaths, 3,641 cases of cervical cancer and 106,898 CIN treatments over 100 years at 56% uptake. Compared with the quadrivalent vaccine, which would prevent an estimated 67% and 72% of cervical cancer cases at 56% and 80% coverage, the nonavalent vaccine would prevent 83% and 89% of all cervical cancers at the same coverage rates. The sensitivity analysis shows that introducing the nonavalent vaccination should improve health outcomes and offers a cost-saving alternative to the quadrivalent vaccine under the current price difference.CONCLUSIONSAll scenarios with quadrivalent and nonavalent vaccination are likely to be cost-effective compared with no vaccination. Switching to the nonavalent vaccine at current and improved vaccination uptake is likely to be cost-saving under the investigated price difference.

Cost-effectiveness of HPV vaccination for adults through age 45 years in the United States: Estimates from a simplified transmission model

Vaccine ◽  
2020 ◽  
Vol 38 (50) ◽  
pp. 8032-8039 ◽  
Author(s):  
Harrell W. Chesson ◽  
Elissa Meites ◽  
Donatus U. Ekwueme ◽  
Mona Saraiya ◽  
Lauri E. Markowitz
Keyword(s):  
United States ◽  
Cost Effectiveness ◽  
Hpv Vaccination ◽  
The United States ◽  
Transmission Model

Cost-effectiveness of influenza control measures: a dynamic transmission model-based analysis

2013 ◽  
Vol 141 (12) ◽  
pp. 2581-2594 ◽  
Author(s):  
S.-C. CHEN ◽  
C.-M. LIAO
Keyword(s):  
Cost Effectiveness ◽  
Natural Ventilation ◽  
Seasonal Influenza ◽  
School Setting ◽  
Control Measures ◽  
Transmission Model ◽  
Model Based ◽  
Dynamic Transmission Model ◽  
Influenza Transmission ◽  
The Cost

SUMMARYWe investigated the cost-effectiveness of different influenza control strategies in a school setting in Taiwan. A susceptible-exposure-infected-recovery (SEIR) model was used to simulate influenza transmission and we used a basic reproduction number (R0)–asymptomatic proportion (θ) control scheme to develop a cost-effectiveness model. Based on our dynamic transmission model and economic evaluation, this study indicated that the optimal cost-effective strategy for all modelling scenarios was a combination of natural ventilation and respiratory masking. The estimated costs were US$10/year per person in winter for one kindergarten student. The cost for hand washing was estimated to be US$32/year per person, which was much lower than that of isolation (US$55/year per person) and vaccination (US$86/year per person) in containing seasonal influenza. Transmission model-based, cost-effectiveness analysis can be a useful tool for providing insight into the impacts of economic factors and health benefits on certain strategies for controlling seasonal influenza.

scholarly journals The impact and cost-effectiveness of nonavalent HPV vaccination in the United States: Estimates from a simplified transmission model

2016 ◽  
Vol 12 (6) ◽  
pp. 1363-1372 ◽  
Author(s):  
Harrell W. Chesson ◽  
Lauri E. Markowitz ◽  
Susan Hariri ◽  
Donatus U. Ekwueme ◽  
Mona Saraiya
Keyword(s):  
United States ◽  
Cost Effectiveness ◽  
Hpv Vaccination ◽  
The United States ◽  
Transmission Model ◽  
The Impact

scholarly journals Dynamic transmission model of routine mumps vaccination in Japan

2018 ◽  
Vol 147 ◽  
Author(s):  
Taito Kitano
Keyword(s):  
Sensitivity Analysis ◽  
Cost Effectiveness ◽  
Medical Costs ◽  
Social Costs ◽  
Transmission Model ◽  
National Immunisation Programme ◽  
Dynamic Transmission Model ◽  
Life Years ◽  
Number Of Patients ◽  
The One

AbstractThe mumps vaccine is not included in the national immunisation programme (NIP) of approximately 80 countries including Japan. To investigate the vaccine's cost-effectiveness, we developed a dynamic transmission model for routine one- and two-dose mumps vaccination programs in Japan. We calculated the incremental cost-effectiveness ratio compared with a current programme over a projected 50-year period. We created a Japanese population model and performed dynamic simulation to estimate the number of patients enrolled in the current programme, the routine one-dose programme, and the routine two-dose programme over the next 50 years using the Berkeley Madonna program. We estimated the medical and social costs of natural mumps infections and vaccinations to analyse cost-effectiveness. Finally, we performed a sensitivity analysis with parameters including vaccine cost, vaccine efficacy, medical costs per case, social costs per case, incidence of adverse events and discount rate. Base case analysis showed that both the one-dose and two-dose programmes predominated and that quality-adjusted life years (QALYs) were saved, compared with the current programme. The medical costs, total cost and QALYs saved during the study period in the two-dose programme compared with the current programme were 217 billion JPY, 860 billion JPY and 184 779, respectively. The two-dose programme surpassed the one-dose programme throughout the study period. In all the scenarios of the sensitivity analysis, two-dose vaccination was better than the one-dose programme. This simulation confirmed that the routine two-dose vaccination programme was more cost-effective and QALY-saving than either the one-dose programme or the current programme. Because of the variability of the results between the various models, further simulations with different models should be conducted.

scholarly journals PIH5 Replacing MMR By MMRV in Mexico: Assessement of Cost-Effectiveness Based on a Dynamic Transmission Model

2011 ◽  
Vol 14 (7) ◽  
pp. A558 ◽  
Author(s):  
M. Ouwens ◽  
M. Macias ◽  
A.H. Mascareñas De Los Santos ◽  
J.A. Gomez ◽  
C Sauboin ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Transmission Model ◽  
Dynamic Transmission Model
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