PMS13 EXPERIMENTAL STUDY OF TOPICAL TREATMENT OF RHEUMATOID ARTHRITIS WITH TNF-Î‘ ANTAGONIST

Abstract Objectives Rheumatoid arthritis (RA) patients show an earlier circadian rhythm (i.e. serum melatonin peaks earlier during the night, indicating an earlier timing of the internal circadian pacemaker). In the current study, we examined whether the chronotype, which is influenced by the circadian rhythm, is also earlier. In addition, we explored whether chronotype is related to disease activity and patient-reported outcomes. Methods The chronotype (Munich Chronotype Questionnaire) of patients with RA (n = 121; mean age 60 years, 73% female) was compared with that of subjects from the general population (norm group; n = 1695) with a one-sample t test. In addition, we investigated chronotype in relation to disease activity (Disease Activity Score; DAS), reported morning stiffness, fatigue (Checklist Individual Strength), and health-related quality of life (RAND-36). Results The chronotype of patients with RA was, on average, 23 min (95% CI, 15 to 31 min) earlier than that of the norm group (t(115) = − 5.901, p < 0.001, d = 0.55). Chronotype was not related to disease activity or patient-reported outcomes (p > 0.05). Conclusion As expected, chronotype was earlier in RA patients. However, in this correlational study, chronotype was not related to disease activity or patient-reported outcomes. An experimental study is needed to examine whether delaying the circadian rhythm has a positive influence on these outcomes. This insight could improve our understanding of the pathophysiology of RA and contribute to exploring new treatment possibilities. Key Points• This is the first study examining chronotype in patients with rheumatoid arthritis, and how chronotype relates to disease activity and patient-reported outcomes.• We found an earlier chronotype in patients with rheumatoid arthritis than in subjects from the general population.• In this correlational study, chronotype was not related to disease activity or patient-reported outcomes. An experimental study is needed to examine whether delaying the circadian rhythm positively influences these outcomes.

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EFEKTIVITAS PIJAT PUNGGUNG TERHADAP INTENSITAS NYERI REMATIK SEDANG PADA WANITA LANJUT USIA DI DESA KARYAWANGI KABUPATEN BANDUNG BARAT

Jurnal Skolastik Keperawatan ◽

10.35974/jsk.v3i1.580 ◽

2017 ◽

Vol 3 (1) ◽

pp. 53

Author(s):

Pera Siahaan ◽

Nurhayati Siagian ◽

Yunus Elon

Keyword(s):

Rheumatoid Arthritis ◽

Experimental Study ◽

Sensory Nerve ◽

Pain Scale ◽

Nerve Fibers ◽

Young Age ◽

Rheumatic Pain ◽

Joint Problem ◽

Before And After ◽

Back Massage

ABSTRAK Pendahuluan: Rematik merupakan masalah persendian yang menimbulkan rasa nyeri baik wanita maupun laki-laki dan sering terjadi pada orang tua dibandingkan pada usia muda. Penanganan yang tepat untuk menangani rematik secara nonfarmakologis salah satunya adalah pijat punggung. Pijat punggung dapat menurunkan rasa nyeri, hal ini disebabkan pijat punggung menghasilkan pelepasan endorphin serta menstimulasi serabut saraf sensorik delta â€“A dan serabut C sehingga menurunkan impuls nyeri. Penelitian ini dilakukan untuk mengetahui efektifitas pijat punggung terhadap intensitas skala nyeri sedang pada wanita lanjut usia di Desa Karyawangi Kabupaten Bandung Barat. Penelitian ini merupakan penelitian eksperimen dengan one group pretest-posttest designt. Subjek dalam penelitian ini sebanyak 17 orang sesuai dengan kriteria penelitian. Tingkat nyeri rematik menggunakan Rheumatoid Arthritis Pain Scale (RAPS). Perolehan data nyeri rematik sebelum dan sesudah pemberian intervensi dihitung menggunakan rumus mean. Kemudian dilanjutkan dengan uji statistik melaui uji-t sampel paired. Hasil uji statistik pada pijat punggung menunjukkan bahwa thitung (8,641) > ttabel (2,120) dengan taraf kepercayaan 95% Î± = 0,05 yang berarti bahwa Ho yang menyatakan tidak ada perbedaan pemberian pijat punggung pada wanita lanjut usia di Desa Karyawangi Kabupaten Bandung Barat di tolak. Kesimpulan dari penelitian ini adalah terdapat penurunan yang signifikan terhadap penurunan skala nyeri rematik pada wanita lanjut usia di Desa Karyawangi Kabupaten Bandung Barat. Diskusi: Pemberian intervensi pijat punggung selama dua hari dapat menurunkan skala nyeri sedang rematik. Â Kata Kunci: Nyeri Rematik, Pijat Punggung Â ABSTRACT Introduction: Rheumatism is a joint problem that it was happen in both women and men also often going on old man than at a young age. The best proper handling to handle rheumatism in nonfarmakologi in one exception is backing massage. Back massage can reduce pain this is because back massage produce to release of endorphin and stimulate sensory nerve fibers-A delta and fibers C thus reducing pain impulses. This study was conducted to know the effectiveness of back massage to scale the intensity of pain was in women aged in Karyawangi Village West Bandung. This study was an experimental study with one group pretest and postest design. Subjects of this study were 17 in accordance with the criteria. The level of rheumatism pain data before and after intervention administration was calculated using mean formula and continued with statistic test through paired test-t sample. The result of statistic test of back massage was showed that tcount (8,642) > ttable (2,120) with level of confidence 95 % Î± = 0,05 it mean that Ho there is no significance different administration in back massage for elder women in Karyawangi Village West Bandung Rejected. The conclusion from the study there was decrease in scale a rheumatic pain in women aged in Karyawangi Village West Bandung. Discussion: The gived of intervention is backing massage can reduce pain often. Keywords: Rheumatic pain, Back Massage

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