The effect of breed on age-related changes in behavior and disease prevalence in cognitively normal older community dogs, Canis lupus familiaris

2012 ◽  
Vol 7 (2) ◽  
pp. 61-69 ◽  
Author(s):  
Hannah E. Salvin ◽  
Paul D. McGreevy ◽  
Perminder S. Sachdev ◽  
Michael J. Valenzuela
2021 ◽  
Vol 5 (1) ◽  
pp. 026-031
Author(s):  
A Bello ◽  
HH Wamakko

This research was conducted over period of 3 months with the aim of studying Age related changes of selected bones of forelimb (Scapula, Humerus, Radius and Ulna) in Local Mongrelian Dog (Canis lupus familiaris). The study entails biometrical and gross observations on the bones. The sample bones were acquired from the experimental animals of comparative anatomy in the department. The bones were categorized into various age groups for the research. The length, width, diameter and circumference of the samples (scapula, humerus, radius and ulna bones) were determined for all the groups. The shape, size, color, location, position and relation of each segment of the samples at various stages of development were determined. The differences across the age groups of different samples were observed and recorded. Based on the research result, it was concluded that, the biometric and morphometry data was found to be increasing with advancement of age. A baseline data was established with the view to enhance learning.


Intelligence ◽  
2018 ◽  
Vol 70 ◽  
pp. 22-29 ◽  
Author(s):  
Karra D. Harrington ◽  
Christa Dang ◽  
Yen Ying Lim ◽  
David Ames ◽  
Simon M. Laws ◽  
...  

2021 ◽  
Author(s):  
Amritpal Mudher ◽  
Shreyasi Chatterjee ◽  
Megan Sealey ◽  
Eva Ruiz ◽  
Chrysia Maria Pegasiou ◽  
...  

Tau becomes abnormally hyper-phosphorylated and aggregated in tauopathies like Alzheimers disease (AD). As age is the greatest risk factor for developing AD, it is important to understand how tau protein itself, and the pathways implicated in its turnover, change during aging. We investigated age-related changes in total and phosphorylated tau in brain samples from two cohorts of cognitively normal individuals spanning 19-74 years, without overt neurodegeneration. One cohort utilised resected tissue and the other used post-mortem tissue. Total soluble tau levels declined with age in both cohorts. Phosphorylated tau was undetectable in the post-mortem tissue but was clearly evident in the resected tissue and did not undergo significant age-related change. To ascertain if the decline in soluble tau was correlated with age-related changes in autophagy, three markers of autophagy were tested but only two appeared to increase with age and the third was unchanged. This implies that in individuals who do not develop neurodegeneration, there is an age-related reduction in soluble tau which could potentially be due to age-related changes in autophagy. Thus, to explore how an age-related increase in autophagy might influence tau-mediated dysfunctions in vivo, autophagy was enhanced in a Drosophila model and all age-related tau phenotypes were significantly ameliorated. These data shed light on age-related physiological changes in proteins implicated in AD and highlights the need to study pathways that may be responsible for these changes. It also demonstrates the therapeutic potential of interventions that upregulate turnover of aggregate-prone proteins during aging.


1998 ◽  
Vol 62 (2) ◽  
pp. 115-122 ◽  
Author(s):  
G. De BENEDICTIS ◽  
L. CAROTENUTO ◽  
G. CARRIERI ◽  
M. De LUCA ◽  
E. FALCONE ◽  
...  

2012 ◽  
Author(s):  
Chad S. Rogers ◽  
Larry L. Jacoby ◽  
Mitchell S. Sommers ◽  
Arthur Wingfield

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